Generalized Misner-Sharp Energy in f(R) Gravity

We study generalized Misner-Sharp energy in $f(R)$ gravity in a spherically symmetric spacetime. We find that unlike the cases of Einstein gravity and Gauss-Bonnet gravity, the existence of the generalized Misner-Sharp energy depends on a constraint condition in the $f(R)$ gravity. When the constraint condition is satisfied, one can define a generalized Misner-Sharp energy, but it cannot always be written in an explicit quasi-local form. However, such a form can be obtained in a FRW universe and for static spherically symmetric solutions with constant scalar curvature. In the FRW universe, the generalized Misner-Sharp energy is nothing but the total matter energy inside a sphere with radius $r$, which acts as the boundary of a finite region under consideration. The case of scalar-tensor gravity is also briefly discussed.Comment: Revtex, 17 pages, v2: some references added, to appear in PR

Detection of STAT2 in early stage of cervical premalignancy and in cervical cancer

AbstractObjectiveTo measure the expression pattern of STAT2 in cervical cancer initiation and progression in tissue sections from patients with cervicitis, dysplasia, and cervical cancer.MethodsAntibody against human STAT2 was confirmed by plasmids transient transfection and Western blot. Immunohistochemistry was used to detect STAT2 expression in the cervical biopsies by using the confirmed antibody against STAT2 as the primary antibody.ResultsIt was found that the overall rate of positive STAT2 expression in the cervicitis, dysplasia and cervical cancer groups were 38.5%, 69.4% and 76.9%, respectively. The STAT2 levels are significantly increased in premalignant dysplasia and cervical cancer, as compared to cervicitis (P< 0.05). Noticeably, STAT2 signals were mainly found in the cytoplasm, implying that STAT2 was not biologically active.ConclusionsThese findings reveal an association between cervical cancer progression and augmented STAT2 expression. In conclusion, STAT2 increase appears to be an early detectable cellular event in cervical cancer development

Hawking-Page Phase Transition of black Dp-branes and R-charged black holes with an IR Cutoff

We show that the confinement-deconfinement phase transition of supersymmetric Yang-Mills theories with 16 supercharges in various dimensions can be realized through the Hawking-Page phase transition between the near horizon geometries of black Dp-branes and BPS Dp-branes by removing a small radius region in the geometry in order to realize a confinement phase, which generalizes the Herzog's discussion for the holographic hard-wall AdS/QCD model. Removing a small radius region in the gravitational dual corresponds to introducing an IR cutoff in the dual field theory. We also discuss the Hawking-Page phase transition between thermal $AdS_5$, $AdS_4$, $AdS_7$ spaces and R-charged AdS black holes coming from the spherical reduction of the decoupling limit of rotating D3-, M2-, and M5- branes in type IIB supergravity and 11 dimensional supergravity in grand canonical ensembles, where the IR cutoff also plays a crucial role in the existence of the phase transition.Comment: 34 pages, 18 figures, JHEP3, v2, references added, v3, some explanations adde

Regulation of LYRM1 Gene Expression by Free Fatty Acids, Adipokines, and Rosiglitazone in 3T3-L1 Adipocytes

LYR motif containing 1 (LYRM1) is a novel gene that is abundantly expressed in the adipose tissue of obese subjects and is involved in insulin resistance. In this study, free fatty acids (FFAs) and tumor necrosis factor-α (TNF-α) are shown to upregulate LYRM1 mRNA expression in 3T3-L1 adipocytes. Conversely, resistin and rosiglitazone exert an inhibitory effect on LYRM1 mRNA expression. These results suggest that the expression of LYRM1 mRNA is affected by a variety of factors that are related to insulin sensitivity. LYRM1 may be an important mediator in the development of obesity-related insulin resistance