4,255 research outputs found
Recent Progress of Multiferroic Perovskite Manganites
Many multiferroic materials, with various chemical compositions and crystal
structures, have been discovered in the past years. Among these multiferroics,
some perovskite manganites with ferroelectricity driven by magnetic orders are
of particular interest. In these multiferroic perovskite manganites, not only
their multiferroic properties are quite prominent, but also the involved
physical mechanisms are very plenty and representative. In this Brief Review,
we will introduce some recent theoretical and experimental progress on
multiferroic manganites.Comment: 24 pages, 17 figures. A brief revie
Esophageal Food Impaction: A Homemade Suction Tube Attached to Esophagogastroduodenoscopy for Food Bolus Removal
The most common esophageal foreign body in adults is impacted food bolus. Polypectomy snares, Dormia baskets, retrieval nets, rat-tooth forceps, alligator forceps or polyp graspers are usually used to remove it. Here, we report the case of a 78-year-old woman whose esophagogastroduodenoscopy (EGD) showed a firm goose liver impacted tightly in the lower esophagus; all of the above-mentioned retrieval instruments could not remove it. We used a homemade device by attaching a modified nasogastric tube to an EGD and successfully removed the goose liver by suction under endoscopic visualization. The method is very effective to remove firm and tightly impacted materials in a narrow lumen. When the usual retrieval instruments fail, a homemade suction tube attached to an EGD is an alternative
Applying Cytogenetics in Phylogenetic Studies
Cytogenetics, with its fundamental role in the field of genetic investigation, continues to be an indispensable tool for studying phylogenetics, given that currently molecular evolutionary analyses are more commonly utilized. Chromosomal evolution indicated that genomic evolution occurs at the level of chromosomal segments, namely, the genomic blocks in the size of Mbâlevel. The recombination of homologous blocks, through the mechanisms of insertion, translocation, inversion, and breakage, has been proven to be a major mechanism of speciation and subspecies differentiation. Meanwhile, molecular cytogenetics (fluorescence in situ hybridizationâbased methodologies) had been already widely applied in studying plant genetics since polyploidy is common in plant evolution and speciation. It is now recognized that comparative cytogenetic studies can be used to explore the plausible phylogenetic relationships of the extant mammalian species by reconstructing the ancestral karyotypes of certain lineages. Therefore, cytogenetics remains a feasible tool in the study of comparative genomics, even in this next generation sequencing (NGS) prevalent era
Tuning redox active polyoxometalates for efficient electronâcoupled proton buffer mediated water splitting
We present strategies to tune the redox properties of polyoxometalate clusters to enhance the electronâcoupled protonâbufferâmediated water splitting process, in which the evolution of hydrogen and oxygen can occur in different forms and is separated in time and space. By substituting the heteroatom template in the Kegginâtype polyoxometalate cluster, H6ZnW12O40, it is possible to double the number of electrons and protonation in the redox reactions (from two to four). This increase can be achieved with better matching of the energy levels as indicated by the redox potentials, compared to the ones of wellâstudied H3PW12O40 and H4SiW12O40. This means that H6ZnW12O40 can act as a highâperformance redox mediator in an electrolytic cell for the onâdemand generation of hydrogen with a high decoupling efficiency of 95.5â% and an electrochemical energy efficiency of 83.3â%. Furthermore, the H6ZnW12O40 cluster also exhibits an excellent cycling behaviour and redox reversibility with almost 100â% H2âmediated capacity retention during 200â
cycles and a high coulombic efficiency >92â% each cycle at 30â
mAâcmâ2
Reconstruction of the Kinematics of Landslide and Debris Flow Through Numerical Modeling Supported by Multidisciplinary Data: The 2009 Siaolin, Taiwan Landslide
Correction: COUP-TFII Mediates Progesterone Regulation of Uterine Implantation by Controlling ER Activity
Olmutinib in T790M-positive nonâsmall cell lung cancer after failure of first-line epidermal growth factor receptor-tyrosine kinase inhibitor therapy: A global, phase 2 study
Receptor del factor de crecimiento epidérmico; Cåncer de pulmón de células no pequeñas; Inhibidor de la tirosina quinasaEpidermal growth factor receptor; Non-small cell lung cancer; Tyrosine kinase inhibitorReceptor del factor de creixement epidÚrmic; Cà ncer de pulmó de cÚl·lules no petites; Inhibidor de la tirosina quinasaBackground
In this open-label, international phase 2 study, the authors assessed the efficacy and safety of olmutinib in patients with locally advanced or metastatic nonâsmall cell lung cancer (NSCLC) who had a confirmed T790M mutation and disease progression on previous epidermal growth factor receptor-tyrosine kinase inhibitor therapy.
Methods
Patients aged â„20 years received once-daily oral olmutinib 800 mg continuously in 21-day cycles. The primary endpoint was the objective response rate (patients who had a confirmed best overall response of a complete or partial response), assessed by central review. Secondary endpoints included the disease control rate, the duration of objective response, progression-free survival, and overall survival. Adverse events were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events (version 4.03).
Results
Overall, 162 patients (median age, 63 years; women, >60%) were enrolled from 68 sites in 9 countries. At the time of database cutoff, 23.5% of enrolled patients remained on treatment. The median treatment duration was 6.5 months (range, 0.03-21.68 months). Overall, 46.3% of patients (95% CI, 38.4%-54.3%) had a confirmed objective response (all partial responses). The best overall response (the objective response rate regardless of confirmation) was 51.9% (84 patients; 95% CI, 43.9%-59.8%). The confirmed disease control rate for all patients was 86.4% (95% CI, 80.2%-91.3%). The median duration of objective response was 12.7 months (95% CI, 8.3-15.4 months). Estimated median progression-free survival was 9.4 months (95% CI, 6.9-12.3 months), and estimated median overall survival was 19.7 months (95% CI, 15.1 months to not reached). All patients experienced treatment-emergent adverse events, and 71.6% of patients had grade â„3 treatment-emergent adverse events.
Conclusions
Olmutinib has meaningful clinical activity and a manageable safety profile in patients with T790M-positive nonâsmall cell lung cancer who received previous epidermal growth factor receptor-tyrosine kinase inhibitor therapy.Hanmi Pharmaceutical Co. Ltd
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