Impact of Indoor Mobility Behavior on the Respiratory Infectious Diseases Transmission Trends

The importance of indoor human mobility in the transmission dynamics of respiratory infectious diseases has been acknowledged. Previous studies have predominantly addressed a single type of mobility behavior such as queueing and a series of behaviors under specific scenarios. However, these studies ignore the abstraction of mobility behavior in various scenes and the critical examination of how these abstracted behaviors impact disease propagation. To address these problems, this study considers people's mobility behaviors in a general scenario, abstracting them into two main categories: crowding behavior, related to the spatial aspect, and stopping behavior, related to the temporal aspect. Accordingly, this study investigates their impacts on disease spreading and the impact of individual spatio-temporal distribution resulting from these mobility behaviors on epidemic transmission. First, a point of interest (POI) method is introduced to quantify the crowding-related spatial POI factors (i.e., the number of crowdings and the distance between crowdings) and stopping-related temporal POI factors (i.e., the number of stoppings and the duration of each stopping). Besides, a personal space determined with Voronoi diagrams is used to construct the individual spatio-temporal distribution factor. Second, two indicators (i.e., the daily number of new cases and the average exposure risk of people) are applied to quantify epidemic transmission. These indicators are derived from a fundamental model which accurately predicts disease transmission between moving individuals. Third, a set of 200 indoor scenarios is constructed and simulated to help determine variable values. Concurrently, the influences and underlying mechanisms of these behavioral factors on disease transmission are examined using structural equation modeling and causal inference modeling.....

Cinnamyl 8-meth­oxy-2-oxo-2H-chromene-3-carboxyl­ate

In the crystal structure of the title compound, C20H16O5, the mol­ecule assumes an E configuration with the benzene ring and chromenecarboxyl group located on opposite ends of the C=C double bond. The chromene ring system and benzene ring are oriented at a dihedral angle of 74.66 (12)°. Weak inter­molecular C—H⋯O hydrogen bonding is present in the crystal structure

Identification of LIFR, PIK3R1, and MMP12 as Novel Prognostic Signatures in Gallbladder Cancer Using Network-Based Module Analysis

Background: Gallbladder cancer (GBC) is a rare and aggressive malignancy of the biliary tract with a dismal survival rate. Effective biomarkers and therapeutic targets are urgently needed.Methods: We analyzed gene expression profiles of GBC to identify differentially expressed genes (DEGs) and then used these DEGs to identify functional module biomarkers based on protein functional interaction (FI) networks. We further evaluated the module-gene protein expression and clinical significance with immunohistochemistry staining (IHC) in a tissue microarray (TMA) from 80 GBC samples.Results: Five functional modules were identified. Module 0 included classical cancer signaling pathways, such as Ras and PI3K-Akt; and modules 1–4 included genes associated with muscle cells, fibrinogen, extracellular matrix, and integrins, respectively. We validated the expression of LIFR, PIK3R1, and MMP12, which were hubs or functional nodes in modules. Compared with paired peritumoural tissues, we found that the expression of LIFR (P = 0.002) and PIK3R1 (P = 0.046) proteins were significantly downregulated, and MMP12 (P = 0.006) was significantly upregulated. Further prognostic analysis showed that patients with low expression of LIFR had shorter overall survival than those with high expression (log-rank test P = 0.028), the same trend as for PIK3R1 (P = 0.053) and MMP12 (P = 0.006). Multivariate analysis indicated that expression of MMP12 protein (hazard ratio [HR] = 0.429; 95% confidence interval [CI] 0.198, 0.930; P = 0.032) was one of the significant independent prognostic factors for overall survival.Conclusions: We found a highly reliable FI network, which revealed LIFR, PIK3R1, and MMP12 as novel prognostic biomarker candidates for GBC. These findings could accelerate biomarker discovery and therapeutic development in this cancer

Transcription Factor Crosstalk and Regulatory Networks in Hypopharyngeal Squamous Cell Carcinoma

licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. Received: 2014.03.24; Accepted: 2014.04.18; Published: 2014.06.16 To date, no effective therapeutic treatments have been developed for hypopharyngeal squamous cell carcinoma (HPSCC), a disease that has a five-year survival rate of approximately 31 % because of its late diagnosis and aggressive nature. Despite recent improvements in diagnostic methods, there are no effective measures to prevent or detect HPSCC in an early stage. The goal of the current study was to identify molecular biomarkers and networks that can facilitate the speedy identification of HPSCC patients who could benefit from individualized treatment. Isobaric tags for relative and absolute quantification (iTRAQ) labeling was employed with two-dimensional liquid chromatography-tandem mass spectrometry to identify quantitatively the differentially expressed proteins among three types of HPSCC disease stages. The iTRAQ results were evaluated by literature searches and western blot analysis. For example, FUBP1, one of 412 proteins with significantl

Lumbar posterior group muscle degeneration: Influencing factors of adjacent vertebral body re-fracture after percutaneous vertebroplasty

ObjectiveThe purpose of the study was to explore the influencing factors of adjacent vertebral re-fracture after percutaneous vertebroplasty (PVP) for osteoporosis vertebral compression fractures (OVCFs).MethodsWe retrospectively analyzed the clinical data of 55 patients with adjacent vertebral re-fracture after PVP operation for OVCFs in our hospital from January 2016 to June 2019, they were followed up for 1 year and included in the fracture group. According to the same inclusion and exclusion criteria, we collected the clinical data of 55 patients with OVCFs without adjacent vertebral re-fracture after PVP in the same period and included them in the non-fracture group. We performed univariate and multivariate logistic regression analysis on the influencing factors of adjacent vertebral re-fracture in patients with OVCFs after PVP.ResultsThere were significant differences in body mass index (BMI), bone mineral density (BMD) T-value, amount of bone cement injected, bone cement leakage, history of glucocorticoid use, cross-sectional area (CSA), cross-sectional area asymmetry (CSAA), fat infiltration rate (FIR), and fat infiltration rate asymmetry (FIRA) of lumbar posterior group muscles [multifidus (MF) and erector spinae (ES)] between the two groups (p < 0.05). There was no significant difference in sex, age, or time from the first fracture to operation, the CAS, CSAA, FIR, and FIRA of psoas major (PS) between the two groups (p > 0.05). Multivariate logistic regression showed that a higher dose of bone cement, greater CSAA and FIR of multifidus, and higher CSAA of erector spinae were independent risk factors for recurrent fractures of adjacent vertebrae after PVP.ConclusionThere are many risk factors for recurrent vertebral fracture after PVP in patients with OVCFs, and degeneration of paraspinal muscles (especially posterior lumbar muscles) may be one of the risks

Genomic Characterization Provides New Insights for Detailed Phage- Resistant Mechanism for Brucella abortus

As the causative agent of cattle brucellosis, Brucella abortus commonly exhibits smooth phenotype (by virtue of colony morphology) that is characteristically sensitive to specific Brucella phages, playing until recently a major role in taxonomical classification of the Brucella species by the phage typing approach. We previously reported the discrepancy between traditional phenotypic typing and MLVA results of a smooth phage-resistant (SPR) strain Bab8416 isolated from a 45-year-old custodial worker with brucellosis in a cattle farm. Here, we performed whole genome sequencing and further obtained a complete genome sequence of strain Bab8416 by a combination of multiple NGS technologies and routine PCR sequencing. The detailed genetic differences between B. abortus SPR Bab8416 and large smooth phage-sensitive (SPS) strains were investigated in a comprehensively comparative genomic study. The large indels between B. abortus SPS strains and Bab8416 showed possible divergence between two evolutionary branches at a far phylogenetic node. Compared to B. abortus SPS strain 9-941 (Bab9-941), the specific re-arrangement event in Bab8416 displaying a closer linear relationship with B. melitensis 16M than other B. abortus strains resulted in the truncation of c-di-GMP synthesis, and 3 c-di-GMP-metabolizing genes, were present in Bab8416 and B. melitensis 16M, but absent in Bab9-941 and other B. abortus strains, indicating potential SPR-associated key determinants and novel molecular mechanisms. Moreover, despite almost completely intact smooth LPS related genes, only one mutated OmpA family protein of Bab8416, functionally related to flagellar and efflux pump, was newly identified. Several point mutations were identified to be Bab8416 specific while a majority of them were verified to be B. abortus ST2 characteristic. In conclusion, our study therefore identifies new SPR-associated factors that could play a role in refining and updating Brucella taxonomic schemes and provides resources for further detailed analysis of mechanism for Brucella phage resistance

LAMOST medium-resolution spectroscopic survey of binarity and exotic star (LAMOST-MRS-B): Observation strategy and target selection

LAMOST-MRS-B is one of the sub-surveys of LAMOST medium-resolution (R~7500) spectroscopic survey. It aims at studying the statistical properties (e.g., binary fraction, orbital period distribution, mass ratio distribution) of binary stars and exotic stars. We intend to observe about 30000 stars (10 mag <= G <= 14.5 mag) with at least 10 visits in five years. We first planned to observe 25 plates around the galactic plane in 2018. Then the plates were reduced to 12 in 2019 because of the limitation of observation. At the same time, two new plates located at the high galactic latitude were added to explore binary properties influenced by the different environments. In this survey project, we set the identified exotic and low-metallicity stars with the highest observation priorities. For the rest of the selected stars, we gave higher priority to the relatively brighter stars in order to obtain high-quality spectra as many as possible. Spectra of 49129 stars have been obtained in LAMOST-MRS-B field and released in DR8, of which 28828 and 3375 stars have been visited more than twice and ten times with SNR >= 10, respectively. Most of the sources are B-, A-, and F-type stars with 0.6 < [Fe/H] < 0.4 dex. We also obtain 347 identified variable and exotic stars and about 250 stars with [Fe/H] < 1 dex. We measure radial velocities (RVs) by using 892233 spectra of the stars. The uncertainties of RV achieve about 1 km/s and 10 km/s1 for 95% of late- and early-type stars, respectively. The datasets presented in this paper are available at http://www.doi.org/10.57760/sciencedb.j00113.00035