1,077 research outputs found
Novel CMOS RFIC Layout Generation with Concurrent Device Placement and Fixed-Length Microstrip Routing
With advancing process technologies and booming IoT markets, millimeter-wave
CMOS RFICs have been widely developed in re- cent years. Since the performance
of CMOS RFICs is very sensi- tive to the precision of the layout, precise
placement of devices and precisely matched microstrip lengths to given values
have been a labor-intensive and time-consuming task, and thus become a major
bottleneck for time to market. This paper introduces a progressive
integer-linear-programming-based method to gener- ate high-quality RFIC layouts
satisfying very stringent routing requirements of microstrip lines, including
spacing/non-crossing rules, precise length, and bend number minimization,
within a given layout area. The resulting RFIC layouts excel in both per-
formance and area with much fewer bends compared with the simulation-tuning
based manual layout, while the layout gener- ation time is significantly
reduced from weeks to half an hour.Comment: ACM/IEEE Design Automation Conference (DAC), 201
Improving Conversational Passage Re-ranking with View Ensemble
This paper presents ConvRerank, a conversational passage re-ranker that
employs a newly developed pseudo-labeling approach. Our proposed view-ensemble
method enhances the quality of pseudo-labeled data, thus improving the
fine-tuning of ConvRerank. Our experimental evaluation on benchmark datasets
shows that combining ConvRerank with a conversational dense retriever in a
cascaded manner achieves a good balance between effectiveness and efficiency.
Compared to baseline methods, our cascaded pipeline demonstrates lower latency
and higher top-ranking effectiveness. Furthermore, the in-depth analysis
confirms the potential of our approach to improving the effectiveness of
conversational search.Comment: SIGIR 202
Poincaré Plot of Fingertip Photoplethysmogram Pulse Amplitude Suitable to Assess Diabetes Status
Multiscale entropy (MSE), an estimate of the complexity of physiological signals has been used for assessing diabetes status. This method requires much computation effort. Our study aimed to examine the Poincaré plot, an easier method for computation to differentiate the diabetes status. We selected subjects and divided them into three groups including the non- diabetes (HbA1c ≤ 6.5%, n=22), diabetes with good control (6.5% < HbA1c < 8%, n=23), and diabetes with poor control (HbA1c ≥ 8%, n=17). Poincaré method used consecutive 250 data points of PPG pulse amplitudes from each subject’s right index fingertip. This method resulted in SSR, the standard deviation of the original photoplethysmogram (PPG) pulse amplitude (SD1) and the standard deviation of the interval 1 PPG pulse amplitude (SD2) ratio. The SSR in the three groups of non-diabetes, diabetes with good control and diabetes with poor control were 0.50, 0.28, and 0.23, respectively and differed between groups (P < 0.05). Our findings suggested that the Poincaré plot of right-hand PPG pulse amplitude may be convenient to evaluate diabetes status
Induction of apoptosis by the retinoid inducible growth regulator RIG1 depends on the NC motif in HtTA cervical cancer cells
<p>Abstract</p> <p>Background</p> <p>Retinoid-inducible gene 1 (RIG1), also known as tazarotene-induced gene 3 or retinoic-acid receptor responder 3, is a growth regulator, which induces apoptosis and differentiation. RIG1 is classified into the NC protein family. This study investigated functional domains and critical amino acids associated with RIG1-mediated cell death and apoptosis.</p> <p>Results</p> <p>Using enhanced green fluorescence protein (EGFP)-tagged RIG1 variants, RIG1 proteins with deletion at the NC domain significantly decreased cell death induced by RIG1, and fusion variants containing only the NC domain significantly induced apoptosis of HtTA cervical cancer cells. The EGFP-RIG1-induced apoptosis was significantly decreased in cells expressing N<sup>112</sup>C<sup>113 </sup>motif double- (NC→FG) or triple- (NCR→FGE) mutated RIG1 variants. Using dodecapeptides, nuclear localization and profound cell death was observed in HtTA cells expressing wild type RIG1<sub>111–123 </sub>or Leu<sup>121</sup>-mutated RIG1<sub>111–123</sub>:L→ C peptide, but peptides double- or triple-mutated at the NC motif alone, RIG1<sub>111–123</sub>:NC→FG or RIG1<sub>111–123</sub>:NCR→FGE, were cytoplasmically localized and did not induce apoptosis. The RIG1<sub>111–123 </sub>also induced apoptosis of A2058 melanoma cells but not normal human fibroblasts.</p> <p>Conclusion</p> <p>The NC domain, especially the NC motif, plays the major role in RIG1-mediated pro-apoptotic activity. The RIG1<sub>111–123 </sub>dodecapeptide exhibited strong pro-apoptotic activity and has potential as an anticancer drug.</p
Tazarotene-induced gene 1 inhibits prostaglandin E2-stimulated HCT116 colon cancer cell growth
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