Angle-resolved and resonant photoemission spectroscopy study of the Fermi surface reconstruction in the charge density wave systems CeTe2 and PrTe2

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Diagnostic accuracy of a three-protein signature in women with suspicious breast lesions: a multicenter prospective trial

Background Mammography screening has been proven to detect breast cancer at an early stage and reduce mortality; however, it has low accuracy in young women or women with dense breasts. Blood-based diagnostic tools may overcome the limitations of mammography. This study assessed the diagnostic performance of a three-protein signature in patients with suspicious breast lesions. Findings This trial (MAST; KCT0004847) was a prospective multicenter observational trial. Three-protein signature values were obtained using serum and plasma from women with suspicious lesions for breast malignancy before tumor biopsy. Additionally, blood samples from women who underwent clear or benign mammography were collected for the assays. Among 642 participants, the sensitivity, specificity, and overall accuracy values of the three-protein signature were 74.4%, 66.9%, and 70.6%, respectively, and the concordance index was 0.698 (95% CI 0.656, 0.739). The diagnostic performance was not affected by the demographic features, clinicopathologic characteristics, and co-morbidities of the participants. Conclusions The present trial showed an accuracy of 70.6% for the three-protein signature. Considering the value of blood-based biomarkers for the early detection of breast malignancies, further evaluation of this proteomic assay is warranted in larger, population-level trials. This Multi-protein Assessment using Serum to deTermine breast lesion malignancy (MAST) was registered at the Clinical Research Information Service of Korea with the identification number of KCT0004847 (https://cris.nih.go.kr).This study was supported by the Bertis Inc. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication

Evidential Semantic Mapping in Off-road Environments with Uncertainty-aware Bayesian Kernel Inference

Robotic mapping with Bayesian Kernel Inference (BKI) has shown promise in creating semantic maps by effectively leveraging local spatial information. However, existing semantic mapping methods face challenges in constructing reliable maps in unstructured outdoor scenarios due to unreliable semantic predictions. To address this issue, we propose an evidential semantic mapping, which can enhance reliability in perceptually challenging off-road environments. We integrate Evidential Deep Learning into the semantic segmentation network to obtain the uncertainty estimate of semantic prediction. Subsequently, this semantic uncertainty is incorporated into an uncertainty-aware BKI, tailored to prioritize more confident semantic predictions when accumulating semantic information. By adaptively handling semantic uncertainties, the proposed framework constructs robust representations of the surroundings even in previously unseen environments. Comprehensive experiments across various off-road datasets demonstrate that our framework enhances accuracy and robustness, consistently outperforming existing methods in scenes with high perceptual uncertainties.Comment: Our project website can be found at https://kjyoung.github.io/Homepage/#/Projects/Evidential-Semantic-Mappin

Effect of Mass Transport by Convective Flow on the Distribution of Dissolved Carbon Monoxide in a Stirred Tank

The dissolved gas concentration in a stirred tank has significant importance in the chemical and biological processing industries as mass transfer from the injected gas to an aqueous solution must occur for the gas to be usable. As the solubility of the gas in the solution is low and there are no probes for measuring dissolved gas concentration, a volumetric mass transfer coefficient is selected as a criterion of design for the scale-up of stirred reactors. However, it is difficult to accurately predict the non-equilibrium state dissolved gas distribution using only the volumetric mass transfer coefficient. In this study, computational fluid dynamics (CFD)-based numerical analysis was conducted to systematically evaluated the effects of mass transport by convective flow on the distribution of dissolved carbon monoxide in a stirred tank. The dissolved carbon monoxide distribution and the volumetric mass transfer coefficient were compared at various rotational speeds of the impellers. At a rotational speed of 900 RPM, the Pearson correlation coefficient was about 0.52, which denotes a moderate correlation. In contrast, Pearson correlation coefficients less than 0.20 were obtained for speeds less than 700 RPM, indicating a weak correlation. By considering the dissolved carbon monoxide transport that occurs during convective flow in stirred tanks, we can provide more accurate information about the dissolved carbon monoxide distribution

Effect of Mass Transport by Convective Flow on the Distribution of Dissolved Carbon Monoxide in a Stirred Tank

The dissolved gas concentration in a stirred tank has significant importance in the chemical and biological processing industries as mass transfer from the injected gas to an aqueous solution must occur for the gas to be usable. As the solubility of the gas in the solution is low and there are no probes for measuring dissolved gas concentration, a volumetric mass transfer coefficient is selected as a criterion of design for the scale-up of stirred reactors. However, it is difficult to accurately predict the non-equilibrium state dissolved gas distribution using only the volumetric mass transfer coefficient. In this study, computational fluid dynamics (CFD)-based numerical analysis was conducted to systematically evaluated the effects of mass transport by convective flow on the distribution of dissolved carbon monoxide in a stirred tank. The dissolved carbon monoxide distribution and the volumetric mass transfer coefficient were compared at various rotational speeds of the impellers. At a rotational speed of 900 RPM, the Pearson correlation coefficient was about 0.52, which denotes a moderate correlation. In contrast, Pearson correlation coefficients less than 0.20 were obtained for speeds less than 700 RPM, indicating a weak correlation. By considering the dissolved carbon monoxide transport that occurs during convective flow in stirred tanks, we can provide more accurate information about the dissolved carbon monoxide distribution