Factors Associated with Bone Mineral Density in Elite Female Gymnasts

Results: Age of gymnasts was positively associated with BMD at all measured sites (p \u3c0.001; r=0.62-0.68). Weight was positively associated with BMD at all measured sites (p \u3c0.001; r=0.82-0.90). Lean body mass was positively associated with BMD at all measured sites (p \u3c0.001; r=0.74-0.87). Body fat percentage was positively associated with BMD at all measured sites (p \u3c0.001-p=0.01; r=0.39-0.54). However, calcium intake was not significantly associated with any of the BMD sites. Sunlight exposure and indirect estimates of vitamin D were not significantly associated with any of the BMD sites; all r-values indicated a weak positive association with BMD. Of the gymnasts who had experienced menses (n=15), those with regular menstrual periods (n=8) had significantly higher BMD values at the arm, leg, trunk, rib, and spine, and total body than those who did not have regular menstrual periods (n=7). There was no significant difference in BMD for gymnasts who had regular periods at the pelvis. A regression analysis was performed. The predictors total BMD values from the regression equation were the following: regular menses, height, weight, percent kilocalorie requirement consumed from predicted kilocalorie needs, calcium intake with supplements, lean body mass, hourly deficits \u3e300 kilocalories from predicted kilocalorie needs, and hourly surpluses \u3e300 kilocalories from predicted kilocalorie needs

Giving away used injection equipment: missed prevention message?

Abstract Background Our objective was to examine factors associated with distributive injection equipment sharing and how needle exchange programs (NEPs) can help reduce distributive sharing among injection drug users (IDUs). Methods 145 English speaking Canadian IDUs ages 16 years and over who had injected in the past 30 days were recruited for a cross-sectional survey. Participants were asked about their socio-demographic characteristics, HIV risk behaviours, social support, drug treatment readiness, program satisfaction, health and social service use and NEP drug use. Bivariate statistics and logistic regression were used to characterize the population and examine correlates of sharing behaviour. Results More IDUs reported distributive sharing of cookers (45%) than needles (36%) or other types of equipment (water 36%; filters 29%; swabs 8%). Regression analyses revealed the following factors associated with distributing used cookers: a history of cocaine/crack injection, an Addiction Severity Index (ASI) score indicative of a mental health problem, and older than 30 years of age. Factors associated with giving away used water included: male, injected methadone, injected other stimulants and moved 3+ times in the past 6 months. Factors associated with giving away used filters included: injected cocaine/crack or stayed overnight on the street or other public place. Factors associated with giving away swabs included: an ASI mental health score indicative of a mental health problem, and HCV negative status. Conclusions Our findings show that more IDUs give away cookers than needles or other injection equipment. While the results showed that correlates of sharing differed by piece of equipment, each point to distributive sharing by the most marginalized IDUs. Targeting prevention efforts to reduce equipment sharing in general, and cookers in particular is warranted to reduce use of contaminated equipment and viral transmission

Twisted Conjugacy Classes in Lattices in Semisimple Lie Groups

Given a group automorphism $\phi:\Gamma\to \Gamma$, one has an action of $\Gamma$ on itself by $\phi$-twisted conjugacy, namely, $g.x=gx\phi(g^{-1})$. The orbits of this action are called $\phi$-conjugacy classes. One says that $\Gamma$ has the $R_\infty$-property if there are infinitely many $\phi$-conjugacy classes for every automorphism $\phi$ of $\Gamma$. In this paper we show that any irreducible lattice in a connected semi simple Lie group having finite centre and rank at least 2 has the $R_\infty$-property.Comment: 6 page

Gaudin Models and Bending Flows: a Geometrical Point of View

In this paper we discuss the bihamiltonian formulation of the (rational XXX) Gaudin models of spin-spin interaction, generalized to the case of sl(r)-valued spins. In particular, we focus on the homogeneous models. We find a pencil of Poisson brackets that recursively define a complete set of integrals of the motion, alternative to the set of integrals associated with the 'standard' Lax representation of the Gaudin model. These integrals, in the case of su(2), coincide wih the Hamiltonians of the 'bending flows' in the moduli space of polygons in Euclidean space introduced by Kapovich and Millson. We finally address the problem of separability of these flows and explicitly find separation coordinates and separation relations for the r=2 case.Comment: 27 pages, LaTeX with amsmath and amssym

Global Health Governance and the Commercial Sector: A Documentary Analysis of Tobacco Company Strategies to Influence the WHO Framework Convention on Tobacco Control

Heide Weishaar and colleagues did an analysis of internal tobacco industry documents together with other data and describe the industry's strategic response to the proposed World Health Organization Framework Convention on Tobacco Control

UCS protein function is partially restored in the Saccharomyces cerevisiae she4 mutant with expression of the human UNC45-GC, but not UNC45-SM

A dedicated UNC45, Cro1, She4 (UCS) domain-containing protein assists in the Hsp90-mediated folding of the myosin head. Only weak sequence conservation exists between the single UCS protein of simple eukaryotes (She4 in budding yeast) and the two UCS proteins of higher organisms (the general cell and striated muscle UNC45s; UNC45-GC and UNC45-SM, respectively). In vertebrates, UNC45-GC facilitates cytoskeletal functions, whereas the 55% identical UNC45-SM assists assembly of the contractile apparatus of cardiac and skeletal muscles. A Saccharomyces cerevisiae she4Δ mutant, totally lacking any UCS protein, was engineered to express as its sole Hsp90 either the Hsp90α or the Hsp90β isoforms of human cytosolic Hsp90. A transient induction of the human UNC45-GC, but not UNC45-SM, could rescue the defective endocytosis in these she4Δ cells at 39 °C, irrespective of whether they possessed Hsp90α or Hsp90β. UNC45-GC-mediated rescue of the localisation of a Myo5-green fluorescent protein (GFP) fusion to cortical patches at 39 °C was more efficient in the yeast containing Hsp90α, though this may relate to more efficient functioning of Hsp90α as compared to Hsp90β in these strains. Furthermore, inducible expression of UNC45-GC, but not UNC45-SM, could partially rescue survival at a more extreme temperature (45 °C) that normally causes she4Δ mutant yeast cells to lyse. The results indicate that UCS protein function has been most conserved-yeast to man-in the UNC45-GC, not UNC45-SM. This may reflect UNC45-GC being the vertebrate UCS protein that assists formation of the actomyosin complexes needed for cytokinesis, cell morphological change, and organelle trafficking-events also facilitated by the myosins in yeast

The hERG channel is dependent upon the Hsp90α isoform for maturation and trafficking

Heat shock protein 90 (Hsp90) has emerged as a promising therapeutic target for the treatment of cancer. Several Hsp90 inhibitors have entered clinical trials. However, some toxicological detriments have arisen, such as cardiotoxicity resulting from hERG inhibition following the administration of Hsp90 inhibitors. We sought to investigate this toxicity as hERG has been previously reported as a client protein that depends upon Hsp90 for its maturation and functional trafficking. In this study we show that hERG depends upon a single Hsp90 isoform. hERG preferentially co-immunoprecipitated with Hsp90α and genetic knockdown of Hsp90α, but not Hsp90β, resulted in a trafficking-defective hERG channel. This study demonstrates the importance of delineating the isoform dependence of Hsp90 client proteins and provides rationale for the design of isoform-selective Hsp90 inhibitors that avoid detrimental effect

Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast

Acknowledgments We thank Rebecca Shapiro for creating CaLC1819, CaLC1855 and CaLC1875, Gillian Milne for help with EM, Aaron Mitchell for generously providing the transposon insertion mutant library, Jesus Pla for generously providing the hog1 hst7 mutant, and Cathy Collins for technical assistance.Peer reviewedPublisher PD