Frequency and Use of Medications in Horses Racing at Prairie Meadows

An analysis was made of the horses racing at Prairie Meadows race track in Altoona, Iowa during 1993 to determine the number of entries designated as racing under the influence of phenylbutazone (Bute(RX)), furosemide (Lasix(Rx)) or both medications. In a total of 1379 Quarter Horse entries, 5.7 % raced with no medication, 74.9 % raced on phenylbutazone, 0.5 % raced on furosemide, and 18.9 % raced on both phenylbutazone and furosemide. In a total of 3424 Thoroughbred entries, 2.1 % raced under no medication, 43.6 % raced on phenylbutazone, 0.4 % raced on furosemide, and 53.9 % raced on both phenylbutazone and furosemide. Overall, of the 4803 entries, 3.2 % raced with no medication, 52.6 % raced on phenylbutazone, 0.4 % raced on furosemide, and 43.9 % raced on both phenylbutazone and furosemide

The Effect of Furosemide on Arterial Blood Gases and Performance in Quarter Horses Performing a Fatigue Test on a Treadmill

Four Quarter Horses (1 filly age 2, 1 mare age 5 and 2 geldings ages 3 and 4; average weight 539 kg) were used in a 2 x 2 crossover design. The effects of furosemide (Lasix(Rx)) on arterial blood packed ceii voiume (PCV), hemogiobin (Hb), pH, pO2, pCO2, HCO-3 and base excess (BE) were measured. Plasma lactate, heart rate, and fatigue time were determined as indicators of perlormance while the horses performed a fatigue test on a high-speed treadmill. The left carotid artery was surgically elevated subcutaneously to facilitate collection of arterial blood samples. Horses were conditioned for 13 weeks with increasing intensity then randomly assigned furosemide (F) or physiological saline (C) as treatments. Treatments were administered 4 hours prior to the fatigue test in accordance with racing regulations. Arterial blood samples were collected prior to treatment dose, prior to exercise, at the 2nd, 4th, and 6th minute during the fatigue test, at fatigue, and at the 5th, 15th, 30th, and 45th minute post-exercise. Arterial blood samples were analyzed for blood gases, Hb, PCV, and plasma lactate. Heart rate and fatigue time were recorded. No difference between treatments (P \u3e 0.05) was observed for blood gases except for pCO2 at rest, and HCO-3 and BE at the 2 minute collection period. No difference between treatments (P \u3e 0.05) was observed for Hb, PCV, lactate and heart rate except at 15 minutes post-exercise for Hb and PCV, and 45 minutes postexercise for Hb. Fatigue times were 11 min 56 sec ± 5 min 30 sec for F horses and 11 min 35 sec--± 2 min 6 sec for C horses. No difference (P \u3e 0.05) was observed in fatigue time. Based on our data, the trend indicated that all parameters measured returned to pre-exercise levels more rapidly for furosemide treated horses. However, furosemide did not enhance performance

Nitrogen Metabolites During Exercise in the Horse

239 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1988.In experiment one, eight Quarter Horse mares were intravenously infused prior to exercise with either sodium acetate (control) or ammonium acetate to determine the effect of elevated ammonia (NH\sb3) levels on fatigue development and muscle metabolism. The horses were exercised on an 11% grade treadmill at 4.4 m/s, carrying 27 kg of lead. Time to fatigue was not (P >.05) different between groups. Middle gluteal muscle (im) NH\sb3 and lactate increased (P .05). Treatment did not (P $>$.05) affect plasma or im ala, glu or gln. Urinary orotic acid/creatinine ratio was not (P $>$.05) affected by exercise or treatment and suggests that the urea cycle was not impaired during exercise. These results did not show any metabolic evidence for a role of increased blood NH$\sb3$ in fatigue development at the level of the central nervous system.In a second experiment, six mature Quarter Horse mares were used in a crossover design to assess the effect of dietary protein level on energy and nitrogen metabolism during exercise. After a 2-wk adaptation to either a 9.0% (control) or an 18.5% crude protein (high-protein: HP) diet, each mare performed an exercise test (ET). The ET was performed in the absorptive stage of digestion and consisted of a 15 min exercise period at 4.5 m/s on an 11% grade treadmill. The dietary treatment did not (P $>$.05) affect heart rate or oxygen uptake; however, exercise resulted in an increase (P .05) effects due to treatment. A diet by exercise interaction (P <.01) occurred for plasma ala, being lower in the HP horses. Plasma urea-N, the urinary urea-N/creatinine and orotic acid/creatinine ratio were higher (P <.001) in the HP group. The excretion of urea-N in sweat was also higher (P <.001) in the HP group. Substrate utilization during exercise was not altered by excess dietary protein; however, excess protein stimulated nitrogen metabolism in the horse at rest, during submaximal exercise and during recovery.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD

The Effect of Furosemide on Arterial Blood Gases and Performance in Quarter Horses Performing a Fatigue Test on a Treadmill

Four Quarter Horses (1 filly age 2, 1 mare age 5 and 2 geldings ages 3 and 4; average weight 539 kg) were used in a 2 x 2 crossover design. The effects of furosemide (Lasix(Rx)) on arterial blood packed ceii voiume (PCV), hemogiobin (Hb), pH, pO2, pCO2, HCO-3 and base excess (BE) were measured. Plasma lactate, heart rate, and fatigue time were determined as indicators of perlormance while the horses performed a fatigue test on a high-speed treadmill. The left carotid artery was surgically elevated subcutaneously to facilitate collection of arterial blood samples. Horses were conditioned for 13 weeks with increasing intensity then randomly assigned furosemide (F) or physiological saline (C) as treatments. Treatments were administered 4 hours prior to the fatigue test in accordance with racing regulations. Arterial blood samples were collected prior to treatment dose, prior to exercise, at the 2nd, 4th, and 6th minute during the fatigue test, at fatigue, and at the 5th, 15th, 30th, and 45th minute post-exercise. Arterial blood samples were analyzed for blood gases, Hb, PCV, and plasma lactate. Heart rate and fatigue time were recorded. No difference between treatments (P > 0.05) was observed for blood gases except for pCO2 at rest, and HCO-3 and BE at the 2 minute collection period. No difference between treatments (P > 0.05) was observed for Hb, PCV, lactate and heart rate except at 15 minutes post-exercise for Hb and PCV, and 45 minutes postexercise for Hb. Fatigue times were 11 min 56 sec ± 5 min 30 sec for F horses and 11 min 35 sec--± 2 min 6 sec for C horses. No difference (P > 0.05) was observed in fatigue time. Based on our data, the trend indicated that all parameters measured returned to pre-exercise levels more rapidly for furosemide treated horses. However, furosemide did not enhance performance.</p

Frequency and Use of Medications in Horses Racing at Prairie Meadows

An analysis was made of the horses racing at Prairie Meadows race track in Altoona, Iowa during 1993 to determine the number of entries designated as racing under the influence of phenylbutazone (Bute(RX)), furosemide (Lasix(Rx)) or both medications. In a total of 1379 Quarter Horse entries, 5.7 % raced with no medication, 74.9 % raced on phenylbutazone, 0.5 % raced on furosemide, and 18.9 % raced on both phenylbutazone and furosemide. In a total of 3424 Thoroughbred entries, 2.1 % raced under no medication, 43.6 % raced on phenylbutazone, 0.4 % raced on furosemide, and 53.9 % raced on both phenylbutazone and furosemide. Overall, of the 4803 entries, 3.2 % raced with no medication, 52.6 % raced on phenylbutazone, 0.4 % raced on furosemide, and 43.9 % raced on both phenylbutazone and furosemide.</p

4-H Skills for Life Animal Science Series. Galloping Ahead: Project Activity Guide

This guide is one of over 40 separate pieces developed by teams of Extension Service educators, volunteers, youth, professional writers and artists from the 12 states of the North Central Region. This series is arranged in a set of four books dealing with horses. Each set has three youth guides that were developed for three levels of expertise - beginner, intermediate, and advanced. This edition is the intermediate book in the set. The fourth guide is a group activity guide. This archival publication may not reflect current scientific knowledge or recommendations. Current information is available from the University of Minnesota Extension at https://www.extension.umn.edu

4-H Skills for Life Animal Science Series. Blazing the Way: Youth Leadership Guide

This guide is one of over 40 separate pieces developed by teams of Extension Service educators, volunteers, youth, professional writers and artists from the 12 states of the North Central Region. This series is arranged in a set of four books dealing with horses. This set has three youth guides that were developed for three levels of expertise - beginner, intermediate, and advanced. This book is the advanced level in the set. The fourth guide in this set is a group activity guide. This archival publication may not reflect current scientific knowledge or recommendations. Current information available from the University of Minnesota Extension at https://www.extension.umn.edu