Crossing the race divide : interracial sex in antebellum Savannah

This article explores the social significance of inter-racial sexual contact in an antebellum Southern city. How did inter-racial sex challenge the established social hierarchy in Savannah? Was it a controversial issue, viewed as a threat to the social order, or was it accepted as an inevitable evil resulting from a mixed population residing in close proximity

Goal-directed or goal-misdirected - how should we interpret the literature?

Goal-directed therapy (GDT) can be a vague term, meaning different things to different people and, depending on the clinical environment, sometimes even different things to the same person. It can refer to perioperative fluid management, clinicians driving oxygen delivery to supramaximal values, early treatment of sepsis in the emergency department, and even to restriction of perioperative crystalloids with the goal of maintaining preadmission body weight. Understandably, strong opinions about GDT vary; some clinicians consider it essential for perioperative care, others completely ineffective in critically ill patients. This commentary aims to further position the excellent review by Lees and colleagues in the context of the critical care and perioperative setting

On the Spatial Distribution of Hard X-Rays from Solar Flare Loops

The aim of this paper is to investigate the spatial structure of the impulsive phase hard X-ray emission from solar flares. This work is motivated by the YOHKOH and the forthcoming HESSI observations. Summarizing past results, it is shown that the transport effects can account for the observations by inhomogeneous loops where there is a strong field convergence and/or density enhancement at the top of the flaring loop. Scattering by plasma turbulence at the acceleration site or pancake type pitch angle distribution of the accelerated electrons can also give rise to enhanced emission at the loop tops. These could be a natural consequence of acceleration by plasma waves. This paper considers a general case of stochastic scattering and acceleration that leads to an isotropic pitch angle distribution and an enhanced emission from the loop tops or the acceleration site. Following the formalism developed in earlier papers the strength and the spectrum of the radiation expected from the acceleration site and the foot points are evaluated and their dependence on the parameters describing the acceleration process and the flare plasma are determined. The theoretical ratio of these two intensities and relative values of their spectral indices are compared with the YOHKOH observations, demonstrating that the above mentioned parameters can be constrained with such observations. It is shown that future high spatial and spectral resolution observations, for example those expected from HESSI, can begin to distinguish between different models and constrain their parameters.Comment: 37 pages with 20 figures. Accepted for publication in ApJ http://www.astronomy.stanford.ed

Trial of antisense oligonucleotide tofersen for SOD1 ALS

BACKGROUND: The intrathecally administered antisense oligonucleotide tofersen reduces synthesis of the superoxide dismutase 1 (SOD1) protein and is being studied in patients with amyotrophic lateral sclerosis (ALS) associated with mutations in METHODS: In this phase 3 trial, we randomly assigned adults with RESULTS: A total of 72 participants received tofersen (39 predicted to have faster progression), and 36 received placebo (21 predicted to have faster progression). Tofersen led to greater reductions in concentrations of SOD1 in CSF and of neurofilament light chains in plasma than placebo. In the faster-progression subgroup (primary analysis), the change to week 28 in the ALSFRS-R score was -6.98 with tofersen and -8.14 with placebo (difference, 1.2 points; 95% confidence interval [CI], -3.2 to 5.5; P = 0.97). Results for secondary clinical end points did not differ significantly between the two groups. A total of 95 participants (88%) entered the open-label extension. At 52 weeks, the change in the ALSFRS-R score was -6.0 in the early-start cohort and -9.5 in the delayed-start cohort (difference, 3.5 points; 95% CI, 0.4 to 6.7); non-multiplicity-adjusted differences favoring early-start tofersen were seen for other end points. Lumbar puncture-related adverse events were common. Neurologic serious adverse events occurred in 7% of tofersen recipients. CONCLUSIONS: In persons wit

Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes

A number of p-sulfonatocalix[4]arene complexes of the lanthanides (Tb, Gd, and Eu) have been prepared, some in the presence of tetraazamacrocycle 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A), and fully characterised. Crystal structure determinations reveal lanthanide coordination at the sulfonate group, bridging several calixarene units, giving coordination polymers. All complexes in this study have been determined to be relatively non-toxic using in vitro cell assays with CC₅₀ values in the range 30–170 μM

Refined kinematics of the Eastern California shear zone from GPS observations, 1993-1998

Global Positioning System (GPS) results from networks spanning the Eastern California shear zone and adjacent Sierra Nevada block, occupied annually between 1993 and 1998, constrain plate margin kinematics. We use an elastic block model to relate GPS station velocities to long‐term fault slip rate estimates. The model accounts for elastic strain accumulation on the San Andreas fault, as well as faults of the Eastern California shear zone. South of the Garlock fault, 14 mm/yr of dextral shear is distributed across the Eastern California shear zone. Some of this slip penetrates eastward into the Basin and Range, and a collective budget of 13 mm/yr is observed to the north at the latitude of Owens Lake. Model slip rates for two important faults, the Garlock and Owens Valley faults, significantly misfit geologic estimates. By referencing station velocities to stable North America we observe northward‐increasing deformation east of our regional GPS network. At the latitude of Mojave Desert, however, some of this deformation is ascribed to elastic strain accumulation due to a locked San Andreas fault and thus does not represent additional fault‐related, permanent deformation