126 research outputs found
Recommended from our members
Treatability study on the use of by-product sulfur in Kazakhstan for the stabilization of hazardous and radioactive wastes
The Republic of Kazakhstan generates significant quantities of excess sulfur from the production and refining of petroleum reserves. In addition, the country also produces hazardous, and radioactive wastes which require treatment/stabilization. In an effort to find secondary uses for the elemental sulfur, and simultaneously produce a material which could be used to encapsulate, and reduce the dispersion of harmful contaminants into the environment, BNL evaluated the use of the sulfur polymer cement (SPC) produced from by-product sulfur in Kazakhstan. This thermoplastic binder material forms a durable waste form with low leaching properties and is compatible with a wide range of waste types. Several hundred kilograms of Kazakhstan sulfur were shipped to the U.S. and converted to SPC (by reaction with 5 wt% organic modifiers) for use in this study. A phosphogypsum sand waste generated in Kazakhstan during the purification of phosphate fertilizer was selected for treatment. Waste loading of 40 wt% were easily achieved. Waste form performance testing included compressive strength, water immersion, and Accelerated Leach Testing. 14 refs., 7 figs., 6 tabs
Recommended from our members
Treatability study on the use of by-product sulfur in Kazakhstan for the stabilization of hazardous and radioactive wastes
The Republic of Kazakhstan generates significant quantities of excess elemental sulfur from the production and refining of petroleum reserves. In addition, the country also produces hazardous, and radioactive wastes which require treatment/stabilization. In an effort to find secondary uses for the elemental sulfur, and simultaneously produce a material which could be used to encapsulate, and reduce the dispersion of harmful contaminants into the environment, BNL evaluated the use of the sulfur polymer cement (SPC) produced from by-product sulfur in Kazakhstan. This thermoplastic binder material forms a durable waste form with low leaching properties and is compatible with a wide range of waste types. Several hundred kilograms of Kazakhstan sulfur were shipped to the US and converted to SPC (by reaction with 5 wt% organic modifiers) for use in this study. A phosphogypsum sand waste generated in Kazakhstan during the purification of phosphate fertilizer was selected for treatment. Waste loadings of 40 wt% were easily achieved. Waste form performance testing included compressive strength, water immersion, and Accelerated Leach Testing
Frequência de lesões macroscópicas em carcaças de bovinos reagentes ao teste tuberculínico
Safety and preliminary efficacy data of a novel Casein Kinase 2 (CK2) peptide inhibitor administered intralesionally at four dose levels in patients with cervical malignancies
<p>Abstract</p> <p>Background</p> <p>Cervical cancer is now considered the second leading cause of death among women worldwide, and its incidence has reached alarming levels, especially in developing countries. Similarly, high grade squamous intraepithelial lesion (HSIL), the precursor stage for cervical cancer, represents a growing health problem among younger women as the HSIL management regimes that have been developed are not fully effective. From the etiological point of view, the presence of Human Papillomavirus (HPV) has been demonstrated to play a crucial role for developing cervical malignancies, and viral DNA has been detected in 99.7% of cervical tumors at the later stages. CIGB-300 is a novel cyclic synthetic peptide that induces apoptosis in malignant cells and elicits antitumor activity in cancer animal models. CIGB-300 impairs the Casein Kinase (CK2) phosphorylation, by targeting the substrate's phosphoaceptor domain. Based on the perspectives of CIGB-300 to treat cancer, this "first-in-human" study investigated its safety and tolerability in patients with cervical malignancies.</p> <p>Methods</p> <p>Thirty-one women with colposcopically and histologically diagnosed microinvasive or pre-invasive cervical cancer were enrolled in a dose escalating study. CIGB-300 was administered sequentially at 14, 70, 245 and 490 mg by intralesional injections during 5 consecutive days to groups of 7 – 10 patients. Toxicity was monitored daily until fifteen days after the end of treatment, when patients underwent conization. Digital colposcopy, histology, and HPV status were also evaluated.</p> <p>Results</p> <p>No maximum-tolerated dose or dose-limiting toxicity was achieved. The most frequent local events were pain, bleeding, hematoma and erythema at the injection site. The systemic adverse events were rash, facial edema, itching, hot flashes, and localized cramps. 75% of the patients experienced a significant lesion reduction at colposcopy and 19% exhibited full histological regression. HPV DNA was negative in 48% of the previously positive patients. Long term follow-up did not reveal recurrences or adverse events.</p> <p>Conclusion</p> <p>CIGB 300 was safe and well tolerated. This is the first clinical trial where a drug has been used to target the CK2 phosphoaceptor domain providing an early proof-of-principle of a possible clinical benefit.</p
Recommended from our members
Laboratory evaluation of performance and durability of polymer grouts for subsurface hydraulic/diffusion barriers. Informal report, October 1993--May 1994
Contaminated soils, buried waste and leaking underground storage tanks pose a threat to the environment through contaminant transport. One of the options for control of contaminant migration from buried waste sites is the construction of a subsurface barrier. Subsurface barriers increase the performance of waste disposal sites by providing a low permeability layer that can reduce percolation water migration into the waste site, minimize surface transport of contaminants, and reduce migration of volatile species. Also, a barrier can be constructed to envelop the site or plume completely, there by containing the contaminants and the potential leakage. Portland cement grout curtains have been used for barriers around waste sites. However, large castings of hydraulic cements result invariably in cracking due to shrinkage, thermal stresses induced by the hydration reactions, and wet-dry cycling prevalent at and sites. Therefore, improved, low permeability, high integrity materials are under investigation by the Department of Energy`s (DOE) Office of Technology Development, Integrated Demonstrations and Programs. The binders chosen for characterization include: an acrylic, a vinylester styrene, bitumen, a polyester styrene, furfuryl alcohol, and sulfur polymer cement. These materials cover broad ranges of chemical and physical durability, performance, viscosity, and cost. This report details the results of laboratory formulation, testing, and characterization of several innovative polymer grouts. An appendix containing a database of the barrier materials is at the end of this report
Mixed Waste Focus Area Work Conducted by
Over 1140 yd of radioactively contaminated soil containing toxic mercury (Hg) and several liters of mixedwaste elemental mercury were generated during a Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) removal action at Brookhaven National Laboratory (BNL). The U.S. Department of Energy's (DOE) Office of Science and Technology Mixed Waste Focus Area (DOE MWFA) is sponsoring a comparison of several technologies that may be used to treat these wastes and similar wastes at BNL and other sites across the DOE complex. This report describes work conducted at BNL on the application and pilot-scale demonstration of the newly developed Sulfur Polymer Stabilization/Solidification (SPSS) process for treatment of contaminated mixed-waste soils containing high concentrations (~5000 mg/L) of mercury and liquid elemental mercury. BNL's SPSS (patent pending) process chemically stabilizes the mercury to reduce vapor pressure and leachability and physically encapsulates the waste in a solid matrix to eliminate dispersion and provide long-term durability. Two 55gallon drums of mixed-waste soil containing high concentrations of mercury and about 62 kg of radioactively contaminated elemental mercury were successfully treated. Waste loadings of 60 wt% soil were achieved without resulting in any increase in waste volume, while elemental mercury was solidified at a waste loading of 33 wt% mercury. Toxicity Characteristic Leaching Procedure (TCLP) analyses indicate the final waste form products pass current Environmental Protection Agency (EPA) allowable TCLP concentrations as well as the more stringent proposed Universal Treatment Standards. Mass balance measurements show that 99.7% of the mercury treated was successfully retained within the waste form, while ..
Recommended from our members
BNL Building 650 lead decontamination and treatment feasibility study. Final report
Lead has been used extensively at Brookhaven National Laboratory (BNL) for radiation shielding in numerous reactor, accelerator and other research programs. A large inventory of excess lead (estimated at 410,000 kg) in many shapes and sizes is currently being stored. Due to it`s toxicity, lead and soluble lead compounds are considered hazardous waste by the Environmental Protection Agency. Through use at BNL, some of the lead has become radioactive, either by contamination of the surface or through activation by neutrons or deuterons. This study was conducted at BNL`s Environmental and Waste Technology Center for the BNL Safety and Environmental Protection Division to evaluate feasibility of various treatment options for excess lead currently being stored. The objectives of this effort included investigating potential treatment methods by conducting a review of the literature, developing a means of screening lead waste to determine the radioactive characteristics, examining the feasibility of chemical and physical decontamination technologies, and demonstrating BNL polyethylene macro-encapsulation as a means of treating hazardous or mixed waste lead for disposal. A review and evaluation of the literature indicated that a number of physical and chemical methods are available for decontamination of lead. Many of these techniques have been applied for this purpose with varying degrees of success. Methods that apply mechanical techniques are more appropriate for lead bricks and sheet which contain large smooth surfaces amenable to physical abrasion. Lead wool, turnings, and small irregularly shaped pieces would be treated more effectively by chemical decontamination techniques. Either dry abrasion or wet chemical methods result in production of a secondary mixed waste stream that requires treatment prior to disposal
Recommended from our members
Thermoplastic Encapsulation Treatability Study of Fernald Silo 1 and Silo 3 Wastes.
- …