1 research outputs found
MORPHOLOGICAL CHANGES IN WISTAR RAT FETUSES FROM PROGENITORS WITH SUCROSE-INDUCED METABOLIC SYNDROME
Women exhibiting the components of metabolic syndrome before the pregnancy have a high risk of fetal
placental dysfunction, even fetal death. Moreover, glucotoxicity has been linked to birth defects. These issues have motivated
checking the possible association between a metabolic syndrome and morphological damages in the conception product.
In this paper, morphological alterations produced on the fetus by the metabolic syndrome of progenitors were determined
in an experimental model. The bio-model was developed in Wistar rats by supplying them with 35 % sucrose from the
intrauterine stage up to eighteen weeks of age. Subsequently, the crossing was performed, the pregnancy was confirmed, and
blood pressure was checked. Two groups of pregnancy were formed; metabolic syndrome and healthy control. Cesarean
section was performed on day twenty of gestation, in order to make the corresponding first segment studies of reproductive
toxicity. Maternal parameters such as body and organ weight were assessed. Weight, crown-rump length, and the total number
of fetuses by group, as well as the skeletal and soft tissue of the fetuses were recorded. The hematoma was the main external
change found, as well as there was a significant decrease in fetuses’ weight of metabolic syndrome parents’ group. In these
fetuses, the absence of Xiphoid and Sterne brae was reported as the principal developmental delays in bone tissue and no
noticeable damage was observed in a soft one. These results suggest that metabolic syndrome morphologically affects
the conception product