Neomicin - čest kontaktni alergen

The incidence of allergic contact dermatitis from neomycin evaluated in relation to 1381 verified cases of allergic contact dermatitis showed a progressive increase (5.00,7.69,10.18%) over a three-year period (1990-1992). Sensitivity to neomycin was investigated with special reference to possible cross-reactions between neomycin and the allergens that are commonly used in the manufacture of cosmetic products. Contact sensitivity to neomycin was found to be present with the other diagnoses, such as atopic dermatitis, seborrhoeic dermatitis, hypostasic dermatitis and psoriasis vulgaris.Pratili smo učestalost kontaktnog alergijskog dermatitisa na neomicin u razdoblju od 1990. do 1992. godine (5,00%; 7,69%, 10,18%) s obzirom na 1381 verificiran kontaktni alergijski dermatitis. Istodobno je prikazan kontaktni alergijski dermatitis s pozitivitetom na neomicin u odnosu na alergene s kojima može imati unakrsne reakcije, a rabe se često u kozmetičkim pripravcima. Prikazali smo kontaktnu senzibilizaciju na neomicin i u drugih dermatoza u kojih se češće javlja: neurodermatitis, seboroički dermatitis, hipostazički dermatitis i vulgarna psorijaza

Polymer-dispersed liquid crystal elastomers

The need for mechanical manipulation during the curing of conventional liquid crystal elastomers diminishes their applicability in the field of shape-programmable soft materials and future applications in additive manufacturing. Here we report on polymer-dispersed liquid crystal elastomers, novel composite materials that eliminate this difficulty. Their thermal shape memory anisotropy is imprinted by curing in external magnetic field, providing for conventional moulding of macroscopically sized soft, thermomechanically active elastic objects of general shapes. The binary soft-soft composition of isotropic elastomer matrix, filled with freeze-fracture-fabricated, oriented liquid crystal elastomer microparticles as colloidal inclusions, allows for fine-tuning of thermal morphing behaviour. This is accomplished by adjusting the concentration, spatial distribution and orientation of microparticles or using blends of microparticles with different thermomechanical characteristics. We demonstrate that any Gaussian thermomechanical deformation mode (bend, cup, saddle, left and right twist) of a planar sample, as well as beat-like actuation, is attainable with bilayer microparticle configurations

Kontaktna alergija i psorijaza

The study was conducted over a two-year period and included 48 psoriatic patients with palmar and plantar lesions and 61 psoriatic patients without palmar and plantar lesions who served as controls. The objective was to establish the incidence of contact sensitization and its importance as the causative factor in palmar and plantar psoriasis. The most frequent contact allergens were: nickel sulphate, mercapto mix, balsam of Peru, potassium dichromate, mercury mix and fragrance mix. Patch tests were positive in 41.7% psoriatics with palrnar-plantar psoriasis and in only 6.6% of psoriatics without palmar-plantar involvement. The study showed an increased incidence of contact allergy in patients with palmar-planter psoriasis.Istraživanje je provedeno tijekom dvije godine u skupini od 48 pacijenata s palmoplantarnim oblikom psorijaze i u kontrolnoj skupini od 61 pacijenta s psorijazom ali bez oštećenja na dlanovima ili stopalima. Cilj je bio utvrditi učestalost kontaktne senziibilizacije i njeno značenje kao uzročnog faktora u nastanku palmoplanlarne psorijaze. Najčešći kontaktni alergeni bili su nikalj sulfat, smjesa merkapto spojeva, peruvijanski balzam, kalijev bikromat, smjesa živinih spojeva i smjesa mirisa. Epikutani testovi bili su pozitivni u 41,7 % pacijenata s palmoplanlarnom psorijazom i samo u 6,6 % kontrolnih pacijenata. Istraživanje je pokazalo povećanu učestalost kontaktne alergije u pacijenata s palmoplantarnim oblikom psorijaze

SIT in croatia

[No abstract available

GMO quantification: valuable experience and insights for the future

Cultivation and marketing of genetically modified organisms (GMOs) have been unevenly adopted worldwide. To facilitate international trade and to provide information to consumers, labelling requirements have been set up in many countries. Quantitative real-time polymerase chain reaction (qPCR) is currently the method of choice for detection, identification and quantification of GMOs. This has been critically assessed and the requirements for the method performance have been set. Nevertheless, there are challenges that should still be highlighted, such as measuring the quantity and quality of DNA, and determining the qPCR efficiency, possible sequence mismatches, characteristics of taxon-specific genes and appropriate units of measurement, as these remain potential sources of measurement uncertainty. To overcome these problems and to cope with the continuous increase in the number and variety of GMOs, new approaches are needed. Statistical strategies of quantification have already been proposed and expanded with the development of digital PCR. The first attempts have been made to use new generation sequencing also for quantitative purposes, although accurate quantification of the contents of GMOs using this technology is still a challenge for the future, and especially for mixed samples. New approaches are needed also for the quantification of stacks, and for potential quantification of organisms produced by new plant breeding techniques.Mojca Milave, David Dobnik, Litao Yang, Dabing Zhang, Kristina Gruden, Jana Že