Relationship between Family Social Support and Quality of Life for Hypertensive Elderly in Tenggela Village, Tilango District

The elderly have problems related to aspects of decreased physical function, namely a decrease in body systems and a decrease in the ability of the five senses that affect activities. The decrease in the physical condition of the elderly causes a decrease in the efficiency of cardiovascular homeostatic mechanisms, including hypertension. The design of this study used an analytic survey with a cross sectional approach, sampling using total sampling, obtained 58 respondents, then given a questionnaire. The results showed that the p value was 0.001 (p <0.05), which means that there is a significant effect. It can be concluded that there is a relationship between family social support and the quality of life of the elderly with hypertension. So it is hoped that the increase in family social support for the elderly so that they are able to face a happy and optimistic old age

Modelling the removal of an earth bund to maximise seawater ingress into a coastal wetland

Weed infestation is a critical management issue for maintaining the natural values of coastal wetlands across the world. Widespread use of herbicides to control weeds has resulted in environmental issues in the past and has led to the search for more natural control methods such as using saline water. This study investigates management options to restore the natural flow regimes between freshwater wetlands and seawater by removing a bund which was built to grow ponded pasture. The study was carried out in the Mungalla wetland in Queensland, which is an important Nywaigi aboriginal community asset for recreation, cultural and economic activities. The study used modelling and monitoring methods to (a) assess how effective the earth bund was in excluding seawater and (b) the extent to which seawater could enter the wetland without the bund. Eleven scenarios were investigated to estimate seawater ingress under different tide, onshore wind, low atmospheric pressure and sea level rise (SLR) conditions. Results show that removal of the bund reinstated periodic tidal ingress into the wetland. Seawater intrusion was also shown to increase when there were onshore winds and/or low atmospheric pressure associated with cyclones. The greatest impact was under future SLR, where large increases in the inundation frequency and extent are likely to cause a shift in the wetland vegetation towards native salt tolerant species. Findings of this study are useful for examining the potential impact of various management interventions that are being considered for wetland system repair. For example, the removal or height adjustment of tidal barriers, dredging of silted streams, removal of weeds from choked streams and reintroduction of tidal flows to control weed infestation, improve water quality and restore natural values to the wetlands

Effects of different slipping methods on the mortality of sardine, Sardina pilchardus, after purse-seine capture off the Portuguese Southern coast (Algarve)

The effects of two different slipping methods on the survival, physical and physiological response of sardines, Sardina pilchardus, captured in a purse-seine fishery were investigated in southern Portugal. Sardines were collected and transferred into holding tanks onboard a commercial fishing vessel after being captured, crowded and deliberately released using two slipping procedures: standard and modified. The standard slipping procedure aggregated fish at high densities and made them "roll over" the floatline, while the modified procedure aggregated the fish at moderate densities and enabled them to escape through an opening created by adding weights to the floatline. Both slipping methods were compared with minimally harmed non-slipped sardines (sardines collected from the loose pocket of the purse seine). Survival rates were monitored in captivity over 28 days using three replicates for each treatment. The estimated survival of sardines was 43.6% for the non-slipped fish, 44.7% for the modified slipping and 11.7% for the standard slipping treatments. Scale loss indicated the level of physical impact experienced, with dead fish from the non-slipped and modified slipping technique showing significantly lower scale loss than those fish from the standard slipping treatment within the same period. Of the physiological indicators of stress measured, cortisol, glucose, lactate and osmolality attained peak values during slipping and up to the first hours after introduction to captivity. This work indicates that although delayed mortality after release may be substantial, appropriately modified slipping techniques significantly enhance survival of slipped sardines.FCT [SFRH/BPD/116307/2016]; European Commission's Horizon 2020 Research and Innovation Programme [634495

Decision support systems for sustainable logistics: A review and bibliometric analysis

Purpose: Decision-making in logistics is an increasingly complex task for organizations as these involve decisions at strategic, tactical and operational levels coupled with the triple bottom line (TBL) of sustainability. Decision support systems (DSS) played a vital role in arguably solving the challenges associated with decision making in sustainable logistics. This review is a systematic attempt to explore the current state of the research in the domain of DSS for logistics while considering sustainability aspects. Design/methodology/approach: A systematic review approach using a set of relevant keywords with several exclusion criteria was adopted to identify literature related to DSS for sustainable logistics. A total of 40 papers were found from 1994 to 2015, which were then analysed along the dimensions of publishing trend, geographic distribution and collaboration, the most influential journals, affiliations and authors as well as the key themes of identified literature. The analysis was conducted by means of bibliometric and text mapping tools, namely BibExcel, gpsvisualizer, and VOSviewer. Findings: The bibliometric analysis showed that DSS for sustainable logistics is an emerging field; however, it is still evolving but at a slower pace. Furthermore, most of the contributing affiliations belong to the United States and the United Kingdom. The text mining and keyword analysis revealed key themes of identified papers. The inherent key themes were decision models and frameworks to address sustainable logistics issues covering transport, distribution and third party logistics. The most prominent sustainable logistics issue was carbon footprinting. Social impact has been given less attention in comparison to economic and environmental aspects. The literature has adequate room for proposing more effective solutions by considering various types of MCDA (multi-criteria decision analysis) methods and DSS configurations while simultaneously considering economic, environmental and social aspects of sustainable logistics. Moreover, the field has potential to include logistics from wide application areas including freight transport through road, rail, sea, air as well as inter-modal transport, port operations, material handling and warehousing. Originality/value: To the best of the authors’ knowledge, this is the first systematic review of DSS for sustainable logistics using bibliometric and text analysis. The key themes and research gaps identified in this paper will provide a reference point that will encourage and guide interested researchers for future study, thus aiding both theoretical and practical advancements in this discipline

Regulation of microtubule-based transport by MAP4

Microtubule (MT)-based transport of organelles driven by the opposing MT motors kinesins and dynein is tightly regulated in cells, but the underlying molecular mechanisms remain largely unknown. Here we tested the regulation of MT transport by the ubiquitous protein MAP4 using Xenopus melanophores as an experimental system. In these cells, pigment granules (melanosomes) move along MTs to the cell center (aggregation) or to the periphery (dispersion) by means of cytoplasmic dynein and kinesin-2, respectively. We found that aggregation signals induced phosphorylation of threonine residues in the MT-binding domain of the Xenopus MAP4 (XMAP4), thus decreasing binding of this protein to MTs. Overexpression of XMAP4 inhibited pigment aggregation by shortening dynein-dependent MT runs of melanosomes, whereas removal of XMAP4 from MTs reduced the length of kinesin-2–dependent runs and suppressed pigment dispersion. We hypothesize that binding of XMAP4 to MTs negatively regulates dynein-dependent movement of melanosomes and positively regulates kinesin-2–based movement. Phosphorylation during pigment aggregation reduces binding of XMAP4 to MTs, thus increasing dynein-dependent and decreasing kinesin-2–dependent motility of melanosomes, which stimulates their accumulation in the cell center, whereas dephosphorylation of XMAP4 during dispersion has an opposite effect

Tick Salivary Gland Extract Induces Alpha-Gal Syndrome In Alpha-Gal Deficient Mice

Introduction: Alpha-gal syndrome (AGS) is characterized by delayed hypersensitivity to non-primate mammalian meat in people having specific immunoglobulin E (sIgE) to the oligosaccharide galactose-alpha-1,3-galactose. AGS has been linked to tick bites from Amblyomma americanum (Aa) in the U.S. A small animal model of meat allergy is needed to study the mechanism of alpha-gal sensitization, the effector phase leading to delayed allergic responses and potential therapeutics to treat AGS. Methods: Eight- to ten-weeks old mice with a targeted inactivation of alpha-1,3-galactosyltransferase (AGKO) were injected intradermally with 50 μg of Aa tick salivary gland extract (TSGE) on days 0, 7, 21, 28, 42, and 49. Total IgE and alpha-gal sIgE were quantitated on Day 56 by enzyme-linked immunosorbent assay. Mice were challenged orally with 400 mg of cooked pork kidney homogenate or pork fat. Reaction severity was assessed by measuring a drop in core body temperature and scoring allergic signs. Results: Compared to control animals, mice treated with TSGE had 190-fold higher total IgE on Day 56 (0.60 ± 0.12 ng/ml vs. 113.2 ± 24.77 ng/ml; p \u3c 0.001). Alpha-gal sIgE was also produced in AGKO mice following TSGE sensitization (undetected vs. 158.4 ± 72.43 pg/ml). Further, sensitized mice displayed moderate clinical allergic signs along with a drop in core body temperature of ≥2°C as an objective measure of a systemic allergic reaction. Interestingly, female mice had higher total IgE responses to TSGE treatment but male mice had larger declines in mean body temperature. Conclusion: TSGE-sensitized AGKO mice generate sIgE to alpha-gal and demonstrate characteristic allergic responses to pork fat and pork kidney. In keeping with the AGS responses documented in humans, mice reacted more rapidly to organ meat than to high fat pork challenge. This mouse model establishes the central role of tick bites in the development of AGS and provides a small animal model to mechanistically study mammalian meat allergy

Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis

Synovial leukocyte apoptosis is inhibited in established rheumatoid arthritis (RA). In contrast, high levels of leukocyte apoptosis are seen in self-limiting crystal arthritis. The phase in the development of RA at which the inhibition of leukocyte apoptosis is first apparent, and the relationship between leukocyte apoptosis in early RA and other early arthritides, has not been defined. We measured synovial fluid leukocyte apoptosis in very early arthritis and related this to clinical outcome. Synovial fluid was obtained at presentation from 81 patients with synovitis of ≤ 3 months duration. The percentages of apoptotic neutrophils and lymphocytes were assessed on cytospin preparations. Patients were assigned to diagnostic groups after 18 months follow-up. The relationship between leukocyte apoptosis and patient outcome was assessed. Patients with early RA had significantly lower levels of neutrophil apoptosis than patients who developed non-RA persistent arthritis and those with a resolving disease course. Similarly, lymphocyte apoptosis was absent in patients with early RA whereas it was seen in patients with other early arthritides. The inhibition of synovial fluid leukocyte apoptosis in the earliest clinically apparent phase of RA distinguishes this from other early arthritides. The mechanisms for this inhibition may relate to the high levels of anti-apoptotic cytokines found in the early rheumatoid joint (e.g. IL-2, IL-4, IL-15 GMCSF, GCSF). It is likely that this process contributes to an accumulation of leukocytes in the early rheumatoid lesion and is involved in the development of the microenvironment required for persistent RA

'I once wore an angry bird t-shirt and went to read Qur’an': asymmetrical institutional complexity and emerging consumption practices in Pakistan

This article brings together theories of institutional logics and the exploration of the lives of tweens in Pakistan to understand how emerging consumption practices fit within Pakistani children’s daily lives, and how institutional complexity that includes the dominance of religion under Pakistani Islamization is negotiated to separate and maintain the differences between them. We identify resolutions to asymmetrical institutional complexity in the consumption of character T-shirts: spatial–temporal practices, visual practices, symbolic substitution practices and single logic practices. We contribute to an understanding of how consumption happens in an Eastern Muslim culture, and how multiple institutional logics shape the consumption practices of children, by articulating how halal consumption practices, far from being essentialist, or presented as market segmentation, form from negotiations and reflections at the boundaries where Islam and Market logics meet