Lithostratigraphy of the Cretaceous–Paleocene Nuussuaq Group, Nuussuaq Basin, West Greenland

The Nuussuaq Basin is the only exposed Cretaceous–Paleocene sedimentary basin in West Greenland and is one of a complex of linked rift basins stretching from the Labrador Sea to northern Baffin Bay. These basins developed along West Greenland as a result of the opening of the Labrador Sea in Late Mesozoic to Early Cenozoic times. The Nuussuaq Basin is exposed in West Greenland between 69°N and 72°N on Disko, Nuussuaq, Upernivik Ø, Qeqertarsuaq, Itsaku and Svartenhuk Halvø and has also been recorded in a number of shallow and deep wells in the region. The sediments are assigned to the more than 6 km thick Nuussuaq Group (new) which underlies the Palaeogene plateau basalts of the West Greenland Basalt Group. The sediment thickness is best estimated from seismic data; in the western part of the area, seismic and magnetic data suggest that the succession is at least 6 km and possibly as much as 10 km thick. The exposed Albian–Paleocene part of the succession testifies to two main episodes of regional rifting and basin development: an Early Cretaceous and a Late Cretaceous – Early Paleocene episode prior to the start of sea-floor spreading in mid-Paleocene time. This exposed section includes fan delta, fluviodeltaic, shelfal and deep marine deposits. The Nuussuaq Group is divided into ten formations, most of which have previously been only briefly described, with the exception of their macrofossil content. In ascending stratigraphic order, the formations are: the Kome Formation, the Slibestensfjeldet Formation (new), the Upernivik Næs Formation, the Atane Formation (including four new members – the Skansen, Ravn Kløft, Kingittoq and Qilakitsoq Members – and one new bed, the Itivnera Bed), the Itilli Formation (new, including four new members, the Anariartorfik, Umiivik, Kussinerujuk and Aaffarsuaq Members), the Kangilia Formation (including the redefined Annertuneq Conglomerate Member and the new Oyster–Ammonite Conglomerate Bed), the Quikavsak Formation (including three new members: the Tupaasat, Nuuk Qiterleq and Paatuutkløften Members), the Agatdal Formation, the Eqalulik Formation (new, including the Abraham Member), and the Atanikerluk Formation (including five members: the Naujât, Akunneq (new), Pingu (new), Umiussat and Assoq (new) Members)

Exercise training complementary to specialised early intervention in patients with first-episode psychosis: a feasibility randomised trial

Abstract Background The aim of this study was to examine feasibility of trial processes and group-based, structured exercise training in patients with first-episode psychosis. Methods Twenty-five patients with first-episode psychosis took part in a two-arm randomised feasibility trial. They were individually randomised (1:1) via a computer-generated randomisation sequence and allocated to either an exercise intervention group (INT) or a control group (CON). Patients allocated to INT completed a physical exercise training programme at moderate-to-vigorous intensity, 1 h three times weekly for 8 weeks. CON patients were encouraged to continue their usual level of activity and were offered the training programme after 8 weeks. Primary outcomes included screening rate, recruitment rate, retention rate, attendance and adverse events. Secondary outcomes included heart rate response during training, cardiovascular health (VO2max, resting heart rate, blood pressure), body composition (muscle mass, fat percentage), muscle strength (sit-to-stand, grip strength, jump height) and balance. Results Recruitment lasted 6 weeks and 86 out of 324 patients (27%) were screened, 71 of whom (83%) were deemed eligible. Twenty-five (35%) accepted inclusion (mean age 25.5; mean body mass index 25.1) and were subsequently randomised (INT = 13, CON = 12). Retention of patients was 76% and 52% at the 8-week and 16-week follow-up, respectively. Attendance was 43% (min. 9%, max. 96%). No significant changes were observed between groups in secondary physiological outcome measures. Conclusions Feasibility was challenged by limited recruitment and retention rates, suggesting that modifications are required if a large-scale randomised controlled trial is to be conducted. Recommendations for modifications are presented and discussed. Trial registration Clinicaltrials.gov, NCT03409393 . Retrospectively registered