A clinical description of two cases of orphan diseases in newborns in the intensive care unit

Clinical cases of the leucinosis and Shwachman-Diamond syndrome at newborns, who were in a serious condition in intensive care unit are described. The clinical picture of diseases and steps of diagnostic search are given. The diagnosis «leucinosis» was made at the age of 2 months that led to belated beginning of specific treatment and adversely affected the disease prognosis. The diagnosis of a syndrome of Shvakhman-Daymond was not established intravital because of rarity of this pathology, weak knowledge of pediatricians and comorbid diseases of the patient.В статье описаны клинические случаи лейциноза(ОМ1М #248600) и синдрома Швахмана-Даймонда (0М1М #260400) у новорожденных, получавших лечение в отделении реанимации и интенсивной терапии. Приведены клиническая картина заболеваний и этапы диагностического поиска. Диагноз «лейциноз» был поставлен в возрасте 2 месяцев, что привело к позднему началу специфического лечения и неблагоприятно отразилось на прогнозе. Диагноз синдрома Швахмана-Даймонда не был установлен при жизни пациента в виду редкости данной патологии, слабой информированности специалистов и наличия у больного коморбидных заболеваний

Sophisticated falsification and research cycles: Consequences for differential character weighting in phylogenetic systematics

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72703/1/j.1463-6409.1997.tb00424.x.pd

Paleogene Radiation of a Plant Pathogenic Mushroom

Background: The global movement and speciation of fungal plant pathogens is important, especially because of the economic losses they cause and the ease with which they are able to spread across large areas. Understanding the biogeography and origin of these plant pathogens can provide insights regarding their dispersal and current day distribution. We tested the hypothesis of a Gondwanan origin of the plant pathogenic mushroom genus Armillaria and the currently accepted premise that vicariance accounts for the extant distribution of the species. Methods: The phylogeny of a selection of Armillaria species was reconstructed based on Maximum Parsimony (MP), Maximum Likelihood (ML) and Bayesian Inference (BI). A timeline was then placed on the divergence of lineages using a Bayesian relaxed molecular clock approach. Results: Phylogenetic analyses of sequenced data for three combined nuclear regions provided strong support for three major geographically defined clades: Holarctic, South American-Australasian and African. Molecular dating placed the initial radiation of the genus at 54 million years ago within the Early Paleogene, postdating the tectonic break-up of Gondwana. Conclusions: The distribution of extant Armillaria species is the result of ancient long-distance dispersal rather than vicariance due to continental drift. As these finding are contrary to most prior vicariance hypotheses for fungi, our result