Multiple regression models for factors related to ΔeGFR.

<p>Model 1: all variables, Model 2: all variables except total cholesterol, Model 3: significant variables in univariate analysis, Model 4: significant variables in univariate analysis except total cholesterol.</p><p>Abbreviations and symbols: eGFR, estimated glomerular filtration rate; Δ, change in the variable over 2 years; β, standardized regression coefficient; BMI, body mass index; BP, blood pressure; FPG, fasting plasma glucose; HbA_1c, hemoglobin A_1c; HDL, high density lipoprotein; LDL, low density lipoprotein; Hb, hemoglobin.</p><p>Multiple regression models for factors related to ΔeGFR.</p

Prevalence of hyperuricemia (male, n = 1,515; female, n = 1,257).

<p>Hyperuricemia: serum uric acid ≥7 mg/dL in males and ≥6 mg/dL in females.</p><p>Prevalence of hyperuricemia (male, n = 1,515; female, n = 1,257).</p

Change in eGFR over 2 years.

<p>eGFR was classified from stage 1 to stage 3a according to the CKD stage. Note that eGFR changed over 2 years.</p

Disposition of the study population.

<p>Disposition of the study population.</p

Simple linear regression analysis of factors related to ΔeGFR.

<p>All values are expressed as mean ± SD.</p><p>Abbreviations and symbols: eGFR, estimated glomerular filtration rate; Δ, change in the variable over 2 years; β, standardized regression coefficient; MetS, metabolic syndrome; BMI, body mass index; BP, blood pressure; FPG, fasting plasma glucose; HbA_1c, hemoglobin A_1c; HDL, high density lipoprotein; LDL, low density lipoprotein; Hb, hemoglobin.</p><p>Simple linear regression analysis of factors related to ΔeGFR.</p

Characteristics of subjects at baseline and 2 years.

<p>All values are expressed as mean ± SD. <i>P</i> values: a, paired <i>t</i>-test; b, McNemar's test comparing baseline with 2 years.</p><p>Abbreviations and symbols: Δ, change in the variable over 2 years; 95% CI, 95% confidence interval; BMI, body mass index; BP, blood pressure; FPG, fasting plasma glucose; HbA_1c, hemoglobin A_1c; eGFR, estimated glomerular filtration rate; HDL, high density lipoprotein; LDL, low density lipoprotein; Hb, hemoglobin.</p><p>Characteristics of subjects at baseline and 2 years.</p