A FDR-preserving field theory for interacting Brownian particles: one-loop theory and MCT

We develop a field theoretical treatment of a model of interacting Brownian particles. We pay particular attention to the requirement of the time reversal invariance and the fluctuation-dissipation relationship (FDR). The method used is a modified version of the auxiliary field method due originally to Andreanov, Biroli and Lefevre [J. Stat. Mech. P07008 (2006)]. We recover the correct diffusion law when the interaction is dropped as well as the standard mode coupling equation in the one-loop order calculation for interacting Brownian particle systems.Comment: 66 pages, 8 figures, submitted to J. Stat. Mec

Effect of molecular bending on the photodissociation of OCS

At 230 nm, the photodissociation of OCS via a hot band and a triplet state was investigated by selective probing of high rotational levels of product CO (Jϭ45-67) with photofragment imaging spectroscopy: . Additional two-photon IR excitation of the UV photoprepared OCS with intense 1.06 m laser pulses bleaches the UV processes listed above and induces a new excitation channel of OCS: OCS(vϭ0)ϩh(UV͒→OCS*, OCS*ϩ2h(IR͒→CO(X 1 ⌺ ϩ ,J ϳ74)ϩS( 1 S). The bending mode of OCS in the excited states plays a central role in the excitation and dissociation dynamics. Additionally, the alignment effect of OCS by nonresonant infrared laser pulse, which appears on the angular distribution of the photofragment, is discussed

HLA-DRB1 and DQB1 alleles in Japanese type 1 autoimmune hepatitis: The predisposing role of the DR4/DR8 heterozygous genotype

ObjectiveAutoimmune hepatitis (AIH) is a chronic progressive liver disease. AIH is composed predominantly of type 1 in Japanese populations. The genetic and environmental factors are associated with the pathogenesis of AIH. HLA-DRB1*03:01 and *04:01 are associated with type 1 AIH in European and *04:05 in Japanese populations. Here, we conducted an HLA association study in order to find HLA alleles or haplotypes predisposing or protective for Japanese AIH.MethodsHLA-DRB1 and DQB1 genotyping of 360 type 1 AIH patients and 1026 healthy controls was performed.ResultsThe predisposing association of DRB1*04:01 (P = 0.0006, corrected P [Pc] = 0.0193, odds ratio [OR] 2.97, 95% confidence interval [CI] 1.62–5.43), DRB1*04:05 (P = 1.89×10−21, Pc = 5.86×10−20, OR 3.41, 95% CI 2.65–4.38), and DQB1*04:01 (P = 4.66×10−18, Pc = 6.99×10−17, OR 3.89, 95% CI 2.84–5.33) and the protective association of DRB1*13:02 (P = 0.0003, Pc = 0.0080, OR 0.48, 95% CI 0.32–0.72) with Japanese type 1 AIH were observed. An association of the DR4/DR8 heterozygous genotype with Japanese AIH was identified for the first time (P = 3.12×10−9, OR 3.52, 95% CI 2.34–5.29). Susceptible diplotypes were DRB1*04:05-DQB1*04:01/DRB1*08:02-DQB1*03:02 (P = 0.0004, OR 24.77, 95% CI 1.45–424.31) and DRB1*04:05-DQB1*04:01/DRB1*08:03-DQB1*06:01 (P = 1.18×10−6, OR 10.64, 95% CI 3.19–35.46). Serum levels of Immunoglobulin G and Immunoglobulin M, International Autoimmune Hepatitis Group score, positive rate of anti-smooth muscle antibodies, and the rate of definite AIH were higher in AIH patients with DRB1*04:05 than without.ConclusionsThe important roles of specific combinations of DRB1 and DQB1 alleles or haplotypes in the pathogenesis of type 1 AIH were suggested. The association of DR4/DR8 heterozygous genotype suggested the pathologic importance of trans-complementing DQα-β heterodimer molecules encoded by DQA1 allele of one haplotype and the DQB1 allele of the other haplotype, as it was proposed in the HLA association studies of Type 1 diabetes

Obesity and glucose metabolism abnormalities by post-disaster evacuation

Background: The objectives of this study were to determine the longer-term trends in childhood obesity and glucose metabolism abnormalities among residents of Fukushima Prefecture 5 years after the Great East Japan Earthquake. Methods: We evaluated the changes in height, weight, body mass index (BMI), BMI SD score, fasting plasma glucose (FPG) concentration, and hemoglobin A1c (HbA1c) among elementary and junior high school residents who had lived in the evacuation zone between 2011 and 2015. Results: Of the residents, 11,112 received health checks in 2011, while in 2012, 2013, 2014, and 2015, 5,737, 4522, 4297 and 3405 received health checks, respectively. The mean BMI SD score for all participants in 2011 was 0.149, and this score gradually decreased from 2011 to 2015. FPG levels and HbA1c levels for all participants with a BMI value +2SD or more in 2011 were higher than those in residents with a BMI value of less than +2SD. The frequency of participants with a FPG level of 126 mg/dl or more and the frequency of participants with a HbA1c level of 6.5% or more in 2011 were higher than those in 2012, 2013, and 2015. Conclusions: These results suggest that a number of pediatric residents suffered from obesity and glucose metabolism abnormalities. However, the longer-term observations indicated an improvement in obesity and glucose metabolism abnormalities. There was a strong association observed between obesity and glucose metabolism, thus, it is important to continue with health checks for children with obesity and strive to improve their health

Classification of First-Episode Schizophrenia Patients and Healthy Subjects by Automated MRI Measures of Regional Brain Volume and Cortical Thickness

BACKGROUND: Although structural magnetic resonance imaging (MRI) studies have repeatedly demonstrated regional brain structural abnormalities in patients with schizophrenia, relatively few MRI-based studies have attempted to distinguish between patients with first-episode schizophrenia and healthy controls. METHOD: Three-dimensional MR images were acquired from 52 (29 males, 23 females) first-episode schizophrenia patients and 40 (22 males, 18 females) healthy subjects. Multiple brain measures (regional brain volume and cortical thickness) were calculated by a fully automated procedure and were used for group comparison and classification by linear discriminant function analysis. RESULTS: Schizophrenia patients showed gray matter volume reductions and cortical thinning in various brain regions predominantly in prefrontal and temporal cortices compared with controls. The classifiers obtained from 66 subjects of the first group successfully assigned 26 subjects of the second group with accuracy above 80%. CONCLUSION: Our results showed that combinations of automated brain measures successfully differentiated first-episode schizophrenia patients from healthy controls. Such neuroimaging approaches may provide objective biological information adjunct to clinical diagnosis of early schizophrenia

Evaluation of Calcium Regulating Roles of Guttation and Calcium Oxalate Crystals in Leaf Blades and Petioles of HydroponicallyGrown Eddo

We investigated the involvement of guttation and calcium oxalate crystals in the maintenance of calcium homeostasis in leaf blades and petioles of eddo in hydroponic solution containing calcium at different concentrations. Under scanning electron microscopy, two types of crystals were observed in leaf blades and petioles: raphides (bundles of needle-shaped crystals) and druses (multifaceted conglomerate crystals). The number and size of crystals of leaf blades and petioles in 1 mMcalcium treatment (control) were smaller than that in 15 mM calcium treatments and larger than that in 0 mM calcium treatment. Calcium contents of leaf blades, petioles and whole plants increased with the increase of calcium concentration in the treatment solution. In addition, calcium-mapping images demonstrated a positive correlation between the amount of calcium in crystal idioblasts and concentration of calcium in treatment solutions. On the other hand, the weight percentage of calcium per mesophyll cell (spongy cell and palisade cell) of leaf blades and per normal parenchyma cell of petioles was stable irrespective of calcium treatment conditions. These results suggest that calcium accumulates in crystals under calcium-excessive conditions and is released from crystals under calcium-deficient conditions to stabilize calcium levels in leaf tissues other than the idioblasts. A positive correlation was observed between the calcium concentration of guttation fluid (μg mL−1), the total amount of calcium in guttation fluid (μg leaf−1night−1) and the calcium concentration of treatment solutions. These results suggest that guttation eliminates excess calcium and would be involved in maintaining calcium ion homeostasis in eddo