9 research outputs found
Π‘ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΡΠ΅ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈΠ²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π² Π΄Π΅ΡΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ
The authors present a review of up-to-date non-invasive visualization methods used in diagnostics of diseases of skin
and its appendages. They describe physical principles forming the basis for non-invasive visualization methods such
as dermatoscopy, confocal laser scanning microscopy, optical video monitoring, optical topometry, optical coherent
tomography, ultrasound scanning, 3D-modeling. They also describe the potential of practical application of these diagnostics
methods at the current stage of their development. The authors have demonstrated that it is possible to reduce the clinicians
need in biopsy diagnostics due to the high information value of non-invasive visual diagnostics methods.ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ ΠΎΠ±Π·ΠΎΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΡ
Π² Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΠΊΠΎΠΆΠΈ ΠΈ Π΅Π΅ ΠΏΡΠΈΠ΄Π°ΡΠΊΠΎΠ². Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠΈΠ½ΡΠΈΠΏΡ, Π»Π΅ΠΆΠ°ΡΠΈΠ΅ Π² ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠ°ΠΊΠΈΡ
Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ, ΠΊΠ°ΠΊ Π΄Π΅ΡΠΌΠ°ΡΠΎΡΠΊΠΎΠΏΠΈΡ, ΠΊΠΎΠ½ΡΠΎΠΊΠ°Π»ΡΠ½Π°Ρ Π»Π°Π·Π΅ΡΠ½Π°Ρ ΡΠΊΠ°Π½ΠΈΡΡΡΡΠ°Ρ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΡ, ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠΈΠΉ
Π²ΠΈΠ΄Π΅ΠΎΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³, ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΎΠΏΠΎΠΌΠ΅ΡΡΠΈΡ, ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΊΠΎΠ³Π΅ΡΠ΅Π½ΡΠ½Π°Ρ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΡ, ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠΎΠ²ΠΎΠ΅ ΡΠΊΠ°Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅,
3D-ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅. Π’Π°ΠΊΠΆΠ΅ ΠΎΠΏΠΈΡΠ°Π½Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠΊΠ°Π·Π°Π½Π½ΡΡ
Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ²
Π½Π° ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΌ ΡΡΠ°ΠΏΠ΅ ΠΈΡ
ΡΠ°Π·Π²ΠΈΡΠΈΡ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΡ Π²ΡΡΠΎΠΊΠΎΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΠΎΡΡΠΈ Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΡΡ
Π²ΠΈΠ·ΡΠ°Π»ΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΠΏΠΎΡΡΠ΅Π±Π½ΠΎΡΡΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠΈΡΡΠΎΠ² Π² ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π±ΠΈΠΎΠΏΡΠΈΠΉ
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π±Π΅Π»ΠΊΠ° PERP Π² ΠΊΠΎΠΆΠ΅ Π±ΠΎΠ»ΡΠ½ΡΡ ΠΈΡΡΠΈΠ½Π½ΠΎΠΉ Π°ΠΊΠ°Π½ΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ·ΡΡΡΠ°ΡΠΊΠΎΠΉ
The authors disclosed the participation of apoptosis proteins in the development of acantholysis in patients with pemphigus. In this connection, studies of the PERP protein passing apoptosis signals and regulating desmosomal functions in keratinocytes are of interest. There is no information about any studies aimed at the PERP protein expression in patients with pemphigus in available literature. Goal. To assess the PERP protein expression in the skin of patients with pemphigus. Materials and methods. There was a study of 22 patients with pemphigus, a patient with bullous pemphigoid and ten healthy people. The PERP protein expression was studied in the biopsy materials obtained from lesion foci and apparently healthy skin of the patients as well as healthy people using the indirect immunofluorescence method. Results. The PERP protein expression was revealed in patients with pemphigus on areas of apparently intact skin, in lesion foci in the patient with bullous pemphigoid and skin of healthy volunteers in the membrane of keratinocytes from all epidermal layers.The PERP protein expression in the blister operculum in lesion foci in patients with pemphigus was absent. Conclusion. Substantial differences in the PERP protein expression in the blister operculum and apparently intact skin of patients with pemphigus were revealed.ΠΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΎ ΡΡΠ°ΡΡΠΈΠ΅ Π±Π΅Π»ΠΊΠΎΠ² Π°ΠΏΠΎΠΏΡΠΎΠ·Π° Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ Π°ΠΊΠ°Π½ΡΠΎΠ»ΠΈΠ·Π° ΠΏΡΠΈ ΠΈΡΡΠΈΠ½Π½ΠΎΠΉ Π°ΠΊΠ°Π½ΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ·ΡΡΡΠ°ΡΠΊΠ΅. Π ΡΠ²ΡΠ·ΠΈ Ρ ΡΡΠΈΠΌ Π²ΡΠ·ΡΠ²Π°Π΅Ρ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π±Π΅Π»ΠΊΠ° PERP, ΠΏΠ΅ΡΠ΅Π΄Π°ΡΡΠ΅Π³ΠΎ ΡΠΈΠ³Π½Π°Π»Ρ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° ΠΈ ΡΠ΅Π³ΡΠ»ΠΈΡΡΡΡΠ΅Π³ΠΎ ΡΡΠ½ΠΊΡΠΈΠΈ Π΄Π΅ΡΠΌΠΎΡΠΎΠΌ Π² ΠΊΠ΅ΡΠ°ΡΠΈΠ½ΠΎΡΠΈΡΠ°Ρ
. Π‘Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΎΠ± ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π±Π΅Π»ΠΊΠ° PERP Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈΡΡΠΈΠ½Π½ΠΎΠΉ Π°ΠΊΠ°Π½ΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ·ΡΡΡΠ°ΡΠΊΠΎΠΉ Π² ΡΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ ΠΈ Π·Π°ΡΡΠ±Π΅ΠΆΠ½ΠΎΠΉ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ΅ ΠΎΡΡΡΡΡΡΠ²ΡΡΡ. Π¦Π΅Π»Ρ. ΠΡΠ΅Π½ΠΈΡΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Π±Π΅Π»ΠΊΠ° PERP Π² ΠΊΠΎΠΆΠ΅ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈΡΡΠΈΠ½Π½ΠΎΠΉ Π°ΠΊΠ°Π½ΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ·ΡΡΡΠ°ΡΠΊΠΎΠΉ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ 22 Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈΡΡΠΈΠ½Π½ΠΎΠΉ Π°ΠΊΠ°Π½ΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ·ΡΡΡΠ°ΡΠΊΠΎΠΉ, 1 Π±ΠΎΠ»ΡΠ½ΠΎΠΉ Π±ΡΠ»Π»Π΅Π·Π½ΡΠΌ ΠΏΠ΅ΠΌΡΠΈΠ³ΠΎΠΈΠ΄ΠΎΠΌ ΠΈ 10 Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π»ΠΈΡ. Π Π±ΠΈΠΎΠΏΡΠ°ΡΠ°Ρ
, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΈΠ· ΠΎΡΠ°Π³ΠΎΠ² ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΠΈ Π²ΠΈΠ΄ΠΈΠΌΠΎ Π·Π΄ΠΎΡΠΎΠ²ΠΎΠΉ ΠΊΠΎΠΆΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ
, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΡ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π»ΠΈΡ, ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π½Π΅ΠΏΡΡΠΌΠΎΠΉ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈ ΠΈΠ·ΡΡΠ°Π»ΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Π±Π΅Π»ΠΊΠ° PERP. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Π±Π΅Π»ΠΊΠ° PERP Π²ΡΡΠ²Π»Π΅Π½Π° Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈΡΡΠΈΠ½Π½ΠΎΠΉ Π°ΠΊΠ°Π½ΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ·ΡΡΡΠ°ΡΠΊΠΎΠΉ Π½Π° ΡΡΠ°ΡΡΠΊΠ°Ρ
Π²ΠΈΠ΄ΠΈΠΌΠΎ Π½Π΅ΠΏΠΎΡΠ°ΠΆΠ΅Π½Π½ΠΎΠΉ ΠΊΠΎΠΆΠΈ, Π² ΠΎΡΠ°Π³Π΅ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ Ρ Π±ΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ Π±ΡΠ»Π»Π΅Π·Π½ΡΠΌ ΠΏΠ΅ΠΌΡΠΈΠ³ΠΎΠΈΠ΄ΠΎΠΌ ΠΈ Π² ΠΊΠΎΠΆΠ΅ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π΄ΠΎΠ±ΡΠΎΠ²ΠΎΠ»ΡΡΠ΅Π² Π½Π° ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π΅ ΠΊΠ΅ΡΠ°ΡΠΈΠ½ΠΎΡΠΈΡΠΎΠ² Π²ΡΠ΅Ρ
ΡΠ»ΠΎΠ΅Π² ΡΠΏΠΈΠ΄Π΅ΡΠΌΠΈΡΠ°. ΠΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Π±Π΅Π»ΠΊΠ° PERP Π² ΠΏΠΎΠΊΡΡΡΠΊΠ΅ ΠΏΡΠ·ΡΡΡ Π² ΠΎΡΠ°Π³Π°Ρ
ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈΡΡΠΈΠ½Π½ΠΎΠΉ Π°ΠΊΠ°Π½ΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ·ΡΡΡΠ°ΡΠΊΠΎΠΉ ΠΎΡΡΡΡΡΡΠ²ΠΎΠ²Π°Π»Π°. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Ρ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠ΅ ΡΠ°Π·Π»ΠΈΡΠΈΡ Π² ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π±Π΅Π»ΠΊΠ° PERP Π² ΠΏΠΎΠΊΡΡΡΠΊΠ΅ ΠΏΡΠ·ΡΡΡ ΠΈ Π²ΠΈΠ΄ΠΈΠΌΠΎ Π½Π΅ΠΏΠΎΡΠ°ΠΆΠ΅Π½Π½ΠΎΠΉ ΠΊΠΎΠΆΠ΅ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈΡΡΠΈΠ½Π½ΠΎΠΉ Π°ΠΊΠ°Π½ΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ·ΡΡΡΠ°ΡΠΊΠΎΠΉ
Erythema ab igne Ρ ΡΠ΅Π±Π΅Π½ΠΊΠ° β ΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΠ΅Π»Ρ ΠΏΠ΅ΡΡΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ°
The rare dermatosis erythema ab igne was examined. The rarity of the observation is also determined by the factor, favoring the skin disease development, β the use of notebook, which infrared irradiation caused the illness development. Were described such items as reasons of erythema ab igne development, the clinical picture, peculiarities of diagnostics and treatment. Disease outcomes have been considered. Mechanisms of infrared irradiation, as well as its biologic effects have been represented.ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ ΡΠ΅Π΄ΠΊΠΎΠ³ΠΎ Π΄Π΅ΡΠΌΠ°ΡΠΎΠ·Π° β erythema ab igne. Π Π΅Π΄ΠΊΠΎΡΡΡ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅ΡΡΡ ΠΈ ΡΠ°ΠΊΡΠΎΡΠΎΠΌ, ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°Π²ΡΠΈΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΊΠΎΠΆΠΈ, β ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ°-Π½ΠΎΡΡΠ±ΡΠΊΠ°, ΠΈΠ½ΡΡΠ°ΠΊΡΠ°ΡΠ½ΠΎΠ΅ ΠΈΠ·Π»ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΠΏΡΠΈΠ²Π΅Π»ΠΎ ΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π±ΠΎΠ»Π΅Π·Π½ΠΈ. ΠΠΏΠΈΡΠ°Π½Ρ ΠΏΡΠΈΡΠΈΠ½Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ erythema ab igne, ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΊΠ°ΡΡΠΈΠ½Π°, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ. Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΠΈΡΡ
ΠΎΠ΄Ρ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΈΠ½ΡΡΠ°ΠΊΡΠ°ΡΠ½ΠΎΠ³ΠΎ ΠΈΠ·Π»ΡΡΠ΅Π½ΠΈΡ, Π΅Π³ΠΎ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΡΡΠ΅ΠΊΡΡ
Π ΠΎΠ»Ρ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠ² Π³Π΅Π½Π° PERP Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ Π°ΠΊΠ°Π½ΡΠΎΠ»ΠΈΠ·Π° Ρ Π±ΠΎΠ»ΡΠ½ΡΡ ΠΈΡΡΠΈΠ½Π½ΠΎΠΉ Π°ΠΊΠ°Π½ΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ·ΡΡΡΠ°ΡΠΊΠΎΠΉ
Goal. To determine the nucleotide protein-coding PERP gene sequence and assess the relation between the revealed mutations/polymorphisms and development of true acantholytic pemphigus as well as particular features of its course. Materials and methods. The protein-coding PERP gene DNA sequence was studied by the sequence analysis method in 18 patients with true acantholytic pemphigus. Results. Two polymorphisms were discovered in patients with true acantholytic pemphigus in Exon 3 of the PERP gene for the first time: rs648802 (non-synonymous) and rs648396 (synonymous). The incidence of wild type genotypes in the revealed polymorphisms (Π‘/Π‘ genotype rs648802 and Π’/Π’ genotype rs648396) in healthy volunteers reliably exceeded that in patients (p = 0.049). Patients with true acantholytic pemphigus are characterized by a higher incidence rate of mutant heterozygous genotypes Π‘/G rs648802 and Π’/C rs648396 (p = 0.09). Mutant heterozygous genotypes of the polymorphisms (G/G genotype rs648802 and Π‘/Π‘ genotype rs648396) were revealed in patients with the earlier onset of the disease (41-60 years) (p = 0.025) more often while heterozygous genotypes (Π‘/G genotype rs648802 and T/Π‘ genotype rs648396) were revealed when the disease developed at the age of 61 or older more often (p = 0.01). Conclusion. Identification of the polymorphous genotype by the sequence method or other molecular methods (e.g. PCR) can be used to forecast the terms when true acantholytic pemphigus can emerge in genetically inclined patients. However, it should be noted that it is necessary to specify the preliminary results obtained based on a greater sample of patients with true acantholytic pemphigus.Π¦Π΅Π»Ρ. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Π½ΠΎΠΉ Π±Π΅Π»ΠΎΠΊ-ΠΊΠΎΠ΄ΠΈΡΡΡΡΠ΅ΠΉ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π³Π΅Π½Π° PERP Ρ ΠΎΡΠ΅Π½ΠΊΠΎΠΉ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ Π²ΡΡΠ²Π»Π΅Π½Π½ΡΠΌΠΈ ΠΌΡΡΠ°ΡΠΈΡΠΌΠΈ/ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ°ΠΌΠΈ ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ ΠΈΡΡΠΈΠ½Π½ΠΎΠΉ Π°ΠΊΠ°Π½ΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ·ΡΡΡΠ°ΡΠΊΠΈ, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΠΌΠΈ Π΅Π΅ ΡΠ΅ΡΠ΅Π½ΠΈΡ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ΅ΠΊΠ²Π΅Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° Π±Π΅Π»ΠΎΠΊ-ΠΊΠΎΠ΄ΠΈΡΡΡΡΠ°Ρ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΠΠ Π³Π΅Π½Π° PERP Ρ 18 Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈΡΡΠΈΠ½Π½ΠΎΠΉ Π°ΠΊΠ°Π½ΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ·ΡΡΡΠ°ΡΠΊΠΎΠΉ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΏΠ΅ΡΠ²ΡΠ΅ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈΡΡΠΈΠ½Π½ΠΎΠΉ Π°ΠΊΠ°Π½ΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ·ΡΡΡΠ°ΡΠΊΠΎΠΉ Π² 3-ΠΌ ΡΠΊΠ·ΠΎΠ½Π΅ Π³Π΅Π½Π° PERP Π±ΡΠ»ΠΈ Π²ΡΡΠ²Π»Π΅Π½Ρ Π΄Π²Π° ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ°: rs648802 (Π½Π΅ΡΠΈΠ½ΠΎΠ½ΠΈΠΌΠΈΡΠ½ΡΠΉ) ΠΈ rs648396 (ΡΠΈΠ½ΠΎΠ½ΠΈΠΌΠΈΡΠ½ΡΠΉ). Π§Π°ΡΡΠΎΡΠ° Π²ΡΡΡΠ΅ΡΠ°Π΅ΠΌΠΎΡΡΠΈ Π³Π΅Π½ΠΎΡΠΈΠΏΠΎΠ² Β«Π΄ΠΈΠΊΠΎΠ³ΠΎΒ» ΡΠΈΠΏΠ° Π²ΡΡΠ²Π»Π΅Π½Π½ΡΡ
ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠ² (Π‘/Π‘ Π³Π΅Π½ΠΎΡΠΈΠΏ rs648802 ΠΈ Π’/Π’ Π³Π΅Π½ΠΎΡΠΈΠΏ rs648396) Ρ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π΄ΠΎΠ±ΡΠΎΠ²ΠΎΠ»ΡΡΠ΅Π² Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΠΏΡΠ΅Π²ΡΡΠΈΠ»Π° ΡΠ°ΡΡΠΎΡΡ Π²ΡΡΡΠ΅ΡΠ°Π΅ΠΌΠΎΡΡΠΈ Π΄Π°Π½Π½ΡΡ
Π³Π΅Π½ΠΎΡΠΈΠΏΠΎΠ² Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
(Ρ = 0,049). Π£ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈΡΡΠΈΠ½Π½ΠΎΠΉ Π°ΠΊΠ°Π½ΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ·ΡΡΡΠ°ΡΠΊΠΎΠΉ ΠΎΡΠΌΠ΅ΡΠ΅Π½Π° ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΡ ΠΊ Π±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΡΠΎΠΌΡ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ ΠΌΡΡΠ°Π½ΡΠ½ΡΡ
Π³Π΅ΡΠ΅ΡΠΎΠ·ΠΈΠ³ΠΎΡΠ½ΡΡ
Π³Π΅Π½ΠΎΡΠΈΠΏΠΎΠ² Π‘/G rs648802 ΠΈ Π’/C rs648396 (Ρ = 0,09). ΠΡΡΠ°Π½ΡΠ½ΡΠ΅ Π³ΠΎΠΌΠΎΠ·ΠΈΠ³ΠΎΡΠ½ΡΠ΅ Π³Π΅Π½ΠΎΡΠΈΠΏΡ Π΄Π°Π½Π½ΡΡ
ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠ² (G/G Π³Π΅Π½ΠΎΡΠΈΠΏ rs648802 ΠΈ Π‘/Π‘ Π³Π΅Π½ΠΎΡΠΈΠΏ rs648396) ΡΠ°ΡΠ΅ Π²ΡΡΠ²Π»ΡΠ»ΠΈΡΡ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Π±ΠΎΠ»Π΅Π΅ ΡΠ°Π½Π½ΠΈΠΌ Π½Π°ΡΠ°Π»ΠΎΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ (41-60 Π»Π΅Ρ) (Ρ = 0,025), Π° Π³Π΅ΡΠ΅ΡΠΎΠ·ΠΈΠ³ΠΎΡΠ½ΡΠ΅ Π³Π΅Π½ΠΎΡΠΈΠΏΡ (Π‘/G Π³Π΅Π½ΠΎΡΠΈΠΏ rs648802 ΠΈ T/Π‘ Π³Π΅Π½ΠΎΡΠΈΠΏ rs648396) ΡΠ°ΡΠ΅ ΠΎΠ±Π½Π°ΡΡΠΆΠΈΠ²Π°Π»ΠΈΡΡ ΠΏΡΠΈ ΠΌΠ°Π½ΠΈΡΠ΅ΡΡΠ°ΡΠΈΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ 61 Π³ΠΎΠ΄Π° ΠΈ ΡΡΠ°ΡΡΠ΅ (Ρ = 0,01). ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠ½ΠΎΠ³ΠΎ Π³Π΅Π½ΠΎΡΠΈΠΏΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ΅ΠΊΠ²Π΅Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈΠ»ΠΈ Π΄ΡΡΠ³ΠΈΠΌΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ (Π½Π°ΠΏΡΠΈΠΌΠ΅Ρ ΠΠ¦Π -ΠΠ€Π Π€) ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Π° Ρ ΡΠ΅Π»ΡΡ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΠΎΠΊΠΎΠ² ΠΌΠ°Π½ΠΈΡΠ΅ΡΡΠ°ΡΠΈΠΈ ΠΈΡΡΠΈΠ½Π½ΠΎΠΉ Π°ΠΊΠ°Π½ΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ·ΡΡΡΠ°ΡΠΊΠΈ Ρ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈ ΠΏΡΠ΅Π΄ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΡΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². ΠΠ΄Π½Π°ΠΊΠΎ ΡΠ»Π΅Π΄ΡΠ΅Ρ ΠΏΠΎΠ΄ΡΠ΅ΡΠΊΠ½ΡΡΡ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΡΡΠΎΡΠ½Π΅Π½ΠΈΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΏΡΠ΅Π΄Π²Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² Π½Π° Π±ΠΎΠ»Π΅Π΅ ΠΊΡΡΠΏΠ½ΠΎΠΉ Π²ΡΠ±ΠΎΡΠΊΠ΅ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈΡΡΠΈΠ½Π½ΠΎΠΉ Π°ΠΊΠ°Π½ΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ·ΡΡΡΠ°ΡΠΊΠΎΠΉ
Management of patients at high risk of developing skin melanoma: Organizational and clinical aspects
Early diagnosis of skin melanoma is one of the most reliable ways to improve the prognosis for the life of patients with this tumor. Organization of medical care for patients with a high risk of developing melanoma, together with the use of non-invasive diagnostic methods and teaching the patient the principles of prevention and early diagnosis of skin malignancies should improve the survival rates of patients with melanoma. The article discusses the experience of implementing the Organizational model of medical care for patients with skin neoplasms in Moscow, as well as the key rules for managing patients at risk of developing skin melanoma with special emphasis on recommendations to patients for regular self-examination of the skin, lifestyle correction and the use of photoprotective agents. Β© 2021, Remedium Group Ltd. All rights reserved
Mesenchymal stromal cell therapy alone does not lead to complete restoration of skin parameters in diabetic foot patients within a 3-year follow-up period
Introduction: Mesenchymal stromal cells (MSCs) administration is an effective option for the treatment of diabetic foot ulcers (DFUs). However, to date, studies assessing long-term outcomes and evaluating skin parameters after cell-based therapy are lacking. We presented the clinical outcomes of 3 patients, treated for DFUs with the bone marrow MSCs 3 years earlier. Methods: Ultrasound examination was used to compare collagen density and epidermal thickness in areas of healed ulcers in comparison with non-affected skin used as a control. Ultrasound and dermatoscopy were used to exclude neoplasm formation, to assess scar contracture and wound recurrence. Results: In all patients, no ulcer recurrence was detected, which was lower than the expected 60% rate of re-ulceration in diabetic patients in a 3-year period (OD [odds ratio] = 0.095, P = 0.12). No neoplasm formation, no contracture of hypertrophic scar, and adjacent tissue were registered. Collagen ultrasound density was decreased by 57% (P = 0.053) and epidermal thickness was increased by 72% (P = 0.01) in the area of healed ulcers in all patients. Conclusion: MSCs therapy alone did not result in the complete restoration of the skin parameters within a 3-year period. MSCs may represent important adjuvant to the therapy, however, other novel approaches are required to achieve better results. Β© 2022 The Author(s)
ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΠΏΡΠ΅Π΄ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΠΎΡΡΠΈ ΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΏΡΠΎΡΠΈΠ°Π·Π°
Many findings confirm the influence of neuropsychic factors on the manifestation and exacerbation of the atopic dermatitis and psoriasis. Nowadays it is assumed that by means of neurotransmittersβ secretion the nervous system can influence different processes, including the immune mediated inflammation, which has the key role in the pathogenesis of such dermatosis. The article hereunder contains comprehensive data on prospective trends of following studies of the nervous regulation participation in the pathogenesis of such dermatosis.ΠΠ½ΠΎΠ³ΠΈΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π°ΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π΅ΡΠ²Π½ΠΎ-ΠΏΡΠΈΡ
ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π½Π° ΠΌΠ°Π½ΠΈΡΠ΅ΡΡΠ°ΡΠΈΡ ΠΈ ΡΠΊΠ·Π°ΡΠ΅ΡΠ±Π°ΡΠΈΡ Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΡΠΌΠ°ΡΠΈΡΠ° ΠΈ ΠΏΡΠΎΡΠΈΠ°Π·Π°. Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π΅ΡΡΡ, ΡΡΠΎ Π½Π΅ΡΠ²Π½Π°Ρ ΡΠΈΡΡΠ΅ΠΌΠ° ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ ΡΠ΅ΠΊΡΠ΅ΡΠΈΠΈ Π½Π΅ΠΉΡΠΎΠΌΠ΅Π΄ΠΈΠ°ΡΠΎΡΠΎΠ² ΠΌΠΎΠΆΠ΅Ρ ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΡ, Π²ΠΊΠ»ΡΡΠ°Ρ ΠΈΠΌΠΌΡΠ½ΠΎΠΎΠΏΠΎΡΡΠ΅Π΄ΠΎΠ²Π°Π½Π½ΠΎΠ΅ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΠ΅, ΠΈΠ³ΡΠ°ΡΡΠ΅Π΅ ΠΊΠ»ΡΡΠ΅Π²ΡΡ ΡΠΎΠ»Ρ Π² ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅ Π΄Π°Π½Π½ΡΡ
Π΄Π΅ΡΠΌΠ°ΡΠΎΠ·ΠΎΠ². Π Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΡΠ°ΡΡΠ΅ Π΄Π°Π½Ρ ΠΎΠ±ΠΎΠ±ΡΠ΅Π½Π½ΡΠ΅ ΡΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΎ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡΡ
Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π³ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΡΠ°ΡΡΠΈΡ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ Π² ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅ ΡΡΠΈΡ
Π΄Π΅ΡΠΌΠ°ΡΠΎΠ·ΠΎΠ²