Key Components of Tourism Destination Development

This paper examines variables that contribute to tourism revenues as reported by the state of Kentucky for a sample of 54 counties in Appalachian Kentucky. The study utilized five components of tourism, online promotional information, and reported tourism revenues to identify what variables contribute to regional tourism revenues. Regression analysis using factor scores found two factors influenced employment revenue and one factor influenced direct tourism revenue

Online Learning in Schools of Business: The Impact of Strategy on Course Enrollments

Online education in schools of business is an ongoing, emerging practice. Strategic planning by institutions and programs seeks to identify the most relevant factors in providing the most effective online learning for students. This requires that schools of business figure out what factors positively and directly affect course enrollments. This research study surveyed deans of AACSB-accredited business schools to determine their online learning strategies and practices. The results of the survey and study support online education as a means to meet the increasing needs of a diverse and ever-changing student population both now and in the future

Key Components of Tourism Revenue in Appalachian Kentucky

This paper examines variables that contribute to tourism revenues as reported by the state of Kentucky for a sample of 54 counties in Appalachian Kentucky. The study utilized five components of tourism, online promotional information, and reported tourism revenues to identify what variables contribute to regional tourism revenues. Regression analysis using factor scores found two factors influenced employment and one factor influenced direct tourism revenue

Teaching Old Dogs New Tricks Or Simply Using The Old Tricks At The Right Time

This study used a specially designed questionnaire to explore student perceptions of tertiary service quality and preferences for fourteen commonly used teaching methods within five dimensions of higher learning.  A convenience sample of 243 undergraduate and graduate students was drawn. Overall, the similarities in the service quality gap between these student groups were greater than the differences. Specifically, students perceived their education emphasized learning of facts and principles but they preferred to be taught learning of skills and procedures.  Their most favored learning methods were textbooks and lectures and their least favored learning methods were role playing and team presentations. The perceived comparative value of the effectiveness of alternative teaching tools in accomplishing five dimensions of higher learning is discussed

The Bright Side of Hematopoiesis: Regulatory Roles of ARID3a/Bright in Human and Mouse Hematopoiesis

ARID3a/Bright is a DNA-binding protein that was originally discovered for its ability to increase immunoglobulin transcription in antigen-activated B cells. It interacts with DNA as a dimer through its ARID, or A/T-rich interacting domain. In association with other proteins, ARID3a increased transcription of the immunoglobulin heavy chain and led to improved chromatin accessibility of the heavy chain enhancer. Constitutive expression of ARID3a in B lineage cells resulted in autoantibody production, suggesting its regulation is important. Abnormal ARID3a expression has also been associated with increased proliferative capacity and malignancy. Roles for ARID3a in addition to interactions with the immunoglobulin locus were suggested by transgenic and knockout mouse models. Over-expression of ARID3a resulted in skewing of mature B cell subsets and altered gene expression patterns of follicular B cells, whereas loss of function resulted in loss of B1 lineage B cells and defects in hematopoiesis. More recent studies showed that loss of ARID3a in adult somatic cells promoted developmental plasticity, alterations in gene expression patterns, and lineage fate decisions. Together, these data suggest new regulatory roles for ARID3a. The genes influenced by ARID3a are likely to play pivotal roles in lineage decisions, highlighting the importance of this understudied transcription factor

Online Learning in Schools of Business: The Impact of Strategy on Course Enrollments

Online education in schools of business is an ongoing, emerging practice. Strategic planning by institutions and programs seeks to identify the most relevant factors in providing the most effective online learning for students. This requires that schools of business figure out what factors positively and directly affect course enrollments. This research study surveyed deans of AACSB-accredited business schools to determine their online learning strategies and practices. The results of the survey and study support online education as a means to meet the increasing needs of a diverse and ever-changing student population both now and in the future

Online Patient Portals: If You Build It, Who Will Come?

Research Objective: Many primary care practices have purchased electronic health records (EHRs) and accompanying patient portals. The role online portals may play in quality and outcome improvement will depend not only on who is using such technology, but how it is used. We evaluate the characteristics of patients using an online portal in comparison to those not using, and examine the portal features and functionalities accessed by users.Study Design: Observational, cohort study for which data were obtained from EHR and health system administrative data. Patient-level data (including demographic information, service use, and portal activation and use) were joined with information characterizing clinics in which patients received care (e.g., medical teaching on site, size, and urban/suburban location). The primary study outcome, portal use, was defined by the initiation of at least one online session. Among users, user-initiated clicks were used to determine specific features accessed. Logistic regression models with random effects were fit using the PROC GLIMMIX procedure (SAS software, Version 9.4) to test the role of clinic- and patient-level variables on patient portal activation. Subjects were blocked by physician, nested within clinic, and the Laplace method was used for likelihood approximation.Population Studied: Study eligible patients were aged 18 years and older with an office visit between 4/1/2013 and 3/31/2014 to a primary care physician practicing in one of the 26 primary care clinics of an integrated delivery system serving Detroit, Michigan and the surrounding suburban areas (N=20,282 patients).Principal Findings: As implemented in December 2012, the online portal enabled users to securely schedule appointments, receive appointment reminders, pay bills online, view lab and other test results, manage information about their health, and communicate with care teams via a secure messaging system. Cohort patients were on average 68.7 years of age (SD=14.7), predominately white (65%) or black (30%) race, and 60% female. Within 18 months of implementation, 33% had an activated account, with African Americans (OR=0.50, 95% CI 0.46-0.56), Hispanics (OR=0.63, 95% CI 0.47-0.84), those over aged 70 years (OR=0.48, 95% CI 0.44-0.52), and those preferring a language other than English (OR=0.43, 95% CI 0.31-0.59) less likely to be a portal user. Patients who were married (OR=0.55, 95% CI 1.44-1.67) and more connected with the clinic, as measured by visit frequency and health maintenance visit use, were more likely to be portal users (OR=1.08, 95% CI 1.05-1.10 and OR=1.39, 95% CI 1.27-1.52, respectively). Among users, the medical record access and management feature (95.9%) was most commonly accessed, most often to obtain laboratory testing results (91.7%). The majority of users also accessed appointment management (76.6%) and messaging (59.1%) functionalitiesConclusions: While the diversity of functions accessed by those with a portal account bodes well for the ability of portals to engage patients, without purposeful intervention enhancements to care delivery afforded by portals may be inaccessible to many, including racial/ethnic minorities and those less connected to traditional care services.Implications for Policy or Practice: Online portals have the potential to extend care beyond the confines of traditional office visits, but inattention to who uses portals may exacerbate known disparities in health care access and outcomes

Myocardial ischemic-fibrotic injury after human heart transplantation is associated with increased progression of vasculopathy, decreased cellular rejection and poor long-term outcome

AbstractObjectivesWe sought to assess the influence of peritransplant ischemia and fibrosis on the development of allograft vasculopathy, acute cellular rejection and long-term outcome.BackgroundAllograft vasculopathy is a common long-term complication of cardiac transplantation. One of the potential risk factors is peritransplant allograft ischemia.MethodsOne hundred forty heart transplant recipients had baseline and one-year intravascular ultrasound analysis done to assess the progression of allograft vasculopathy. Serial endomyocardial biopsies were evaluated for cellular rejection, vascular rejection, ischemia and fibrosis. Based on histology, patients were classified into one of the following groups: nonischemic (n = 32), ischemia (n = 24), fibrosis (n = 62) or vascular rejection (n = 22). Three-color flow cytometry crossmatching (FCXM) was used to assess donor-specific human lymphocyte antigens (HLA) sensitization. Long-term outcome of patients in each group was assessed by estimating incidence of graft failure or deaths over a seven-year follow up.ResultsPatients in the fibrosis group had the lowest incidence of donor-specific HLA sensitization (40%, p = 0.008) and lowest average episodes of cellular rejection (1.7 ± 1.4, p = 0.04), but they had increased coronary vasculopathy progression (change in coronary intimal thickness = 0.59 ± 0.28 mm, p < 0.0001) and poor seven-year event-free survival (49%, p = 0.01).ConclusionsThe development of fibrosis after cardiac transplantation is associated with advanced coronary vasculopathy, although a low incidence of acute cellular rejection is noted, suggesting the presence of nonimmune mechanisms in mediating the pathogenesis of allograft vasculopathy