Meson-Baryon Effective Chiral Lagrangian at O(q3)O(q^3) Revisited

After our work [1] was published, Frink and Meissner [2] pointed out that the O(q^3) three-flavour meson-baryon chiral Lagrangian presented there was not minimal. Here, we critically review their paper and revise ours. Remarkably, we find that the effective meson-baryon chiral Lagrangian at O(q^3) contains 76 monomials, i.e. eight less than in [1] and two less than in [2]

Meson-Baryon Effective Chiral Lagrangians at O(q^3) Revisited

After our work was published, Frink and Mei{\ss}ner \cite{FM06} pointed out that our {\cal O}(q^3) three-flavour meson-baryon chiral Lagrangian was not minimal. Here, we discuss their findings and revise ours accordingly. We find that eight monomials in our ${\cal O}(q^3)$ Lagrangian are not independent, but in addition, two monomials were wrongly discarded, which, as a result, makes the agreement in the number of independent monomials with \cite{FM06} complete.Comment: 7 pages, 1 table. A mistake was corrected. Our Lagrangian and that of [2] contain the same number of monomial

Axial Anomaly and Polarized Radiative Decays

We extend the approach of Dolgov and Zakharov to the axial anomaly to study polarized radiative decays. We analyse the pattern of mass singularity cancellation in the corresponding decay rates. We compare polarized and unpolarized cases. The cancellation of the infrared and collinear singularities is verified to all powers of the lepton mass for the $\pi^+$ and $Z^0$ polarized radiative decays.Comment: 18 pages, LaTeX, 4 PostScript figure

Axial Anomaly Effects in Pion and Z0Z^0 Radiative Decays

We discuss a connection between axial anomaly and polarized radiative processes. By comparison with the corresponding unpolarized cases, we consider some physical outputs for the $\pi^+$ and $Z^0$ polarized radiative decays. We analyse in detail the pattern of mass singularity cancellation.Comment: 30 pages, 7 figure

Endothelin-1 as a Mediator of Heme Oxygenase-1-Induced Stemness in Colorectal Cancer: Influence of p53

Heme oxygenase-1 (HO-1) is an antioxidant protein implicated in tumor progression, metastasis, and resistance to therapy. Elevated HO-1 expression is associated with stemness in several types of cancer, although this aspect has not yet been studied in colorectal cancer (CRC). Using an in vitro model, we demonstrated that HO-1 overexpression regulates stemness and resistance to 5-FU treatment, regardless of p53. In samples from CRC patients, HO-1 and endothelin converting enzyme-1 (ECE-1) expression correlated significantly, and p53 had no influence on this result. Carbon monoxide (CO) activated the ECE-1/endothelin-1 (ET-1) pathway, which could account for the protumoral effects of HO-1 in p53 wild-type cells, as demonstrated after treatment with bosentan (an antagonist of both ETRA and ETRB endothelin-1 receptors). Surprisingly, in cells with a non-active p53 or a mutated p53 with gain-of-function, ECE-1-produced ET-1 acted as a protective molecule, since treatment with bosentan led to increased efficiency for spheres formation and percentage of cancer stem cells (CSCs) markers. In these cells, HO-1 could activate or inactivate certain unknown routes that could induce these contrary responses after treatment with bosentan in our cell model. However more research is warranted to confirm these results. Patients carrying tumors with a high expression of both HO-1 and ECE-1 and a non-wild-type p53 should be considered for HO-1 based-therapies instead of ET-1 antagonists-based ones.Instituto de Salud Carlos IIIFEDER (PI18/01947)MINECO grant (DPI2017-84439-R)Nicolás Monardes Program from the Andalusian Health Service (C-0033-2015)FPU2019 fellowship (FPU19/02269) from the Ministerio de Ciencia, Innovación y Universidades (Spain

On flux-limited morphogenesis. Reply to the comments on >Morphogenetic action through flux-limited spreading>.

Spanish MINECO; Marie Curie FP6 (RTN035528-2); FP7(ITN238186); Fundación Areces; Juntad e Andalucía (Project P08-FQM-4267); Swiss National Science Foundation; the University of Geneva; European Research Council; Leenaards foundation; European Molecular Biology Organization (younginvestigatorprogram); Cantonet Republique de GenèvetoPeer Reviewe