Comparison of intra-articular injections of Hyaluronic Acid and Corticosteroid in the treatment of Osteoarthritis of the hip in comparison with intra-articular injections of Bupivacaine. Design of a prospective, randomized, controlled study with blinding of the patients and outcome assessors

<p>Abstract</p> <p>Background</p> <p>Although intra-articular hyaluronic acid is well established as a treatment for osteoarthritis of the knee, its use in hip osteoarthritis is not based on large randomized controlled trials. There is a need for more rigorously designed studies on hip osteoarthritis treatment as this subject is still very much under debate.</p> <p>Methods/Design</p> <p>Randomized, controlled trial with a three-armed, parallel-group design. Approximately 315 patients complying with the inclusion and exclusion criteria will be randomized into one of the following treatment groups: infiltration of the hip joint with hyaluronic acid, with a corticosteroid or with 0.125% bupivacaine.</p> <p>The following outcome measure instruments will be assessed at baseline, i.e. before the intra-articular injection of one of the study products, and then again at six weeks, 3 and 6 months after the initial injection: Pain (100 mm VAS), Harris Hip Score and HOOS, patient assessment of their clinical status (worse, stable or better then at the time of enrollment) and intake of pain rescue medication (number per week). In addition patients will be asked if they have complications/adverse events. The six-month follow-up period for all patients will begin on the date the first injection is administered.</p> <p>Discussion</p> <p>This randomized, controlled, three-arm study will hopefully provide robust information on two of the intra-articular treatments used in hip osteoarthritis, in comparison to bupivacaine.</p> <p>Trial registration</p> <p>NCT01079455</p

Molecular dynamics of weakly coupled electric dipoles on a rigid lattice. I. The approach to equilibrium

The approach to equilibrium of a finite two-dimensional system of 400 rotating dipoles located on the sites of a square lattice is investigated by the technique of molecular dynamics. For all dipoles initially oriented at random and rotating in the same direction with equal velocities, it is verified that the system goes to its equilibrium state and that the relaxation time of the fourth moment of the angular momentum distribution is inversely proportional to the eighth power of the dipole moment, as expected from theory. A particular situation, such that the system does not approach its equilibrium state, is discussed.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Ground-state energy of an electron gas in a lattice of positive point charges

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Electron Gas in a Lattice of Positive Charges

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Indications for immediate percutaneous intramedullary nailing of complete diaphyseal forearm shaft fractures in children.

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Ground state energy of an electron gas in a lattice of positive ions

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Ground-state energy of an electron gas in a lattice of positive ions-cohesive energy of alkali metals and alloys

Our previous calculations for the ground-state energy of a high-density electron gas in a lattice of positive point ions are extended to lattices of real ions with a core of bound electrons. The core effect on the electron gas is taken into account by the method of pseudopotentials put forward by Cohen and Heine. Both cases of lattices covered with one species and two species of ions are discussed. The present model should give a rough picture of metals and alloys and was subsequently applied to alkali metals for which rather simple pseudopotentials have been proposed by Cohen. Numerical results obtained for the cohesion energy of the electron gas and the lattice of ions agree fairly well with the data of pure alkali metals. The heats of mixing of alkali metals have also been calculated with this model: They are very small and agree roughly with the order of magnitude of the experimental data.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Molecular dynamics of electric dipoles on a rigid lattice: The dielectric response function

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Molecular dynamics of weakly coupled electric dipoles on a rigid lattice. II. The dielectric response function

The dielectric response function of a finite two-dimensional system of dipoles is evaluated numerically by the method of molecular dynamics. The dipoles are located on the sites of a rigid square lattice and are only allowed to rotate; the specimen itself is circular and includes 101, 193, or 421 dipoles. Two types of coupling are considered: (a) dipolar interactions and (b) classical exchange interactions favoring either parallel or antiparallel alignment. The corresponding response functions are largely different in each case. For dipolar interactions they differ rather little from the response function corresponding to zero coupling and the influence of the long-range part of the potential seems negligible. On the contrary, exchange interactions lead to response functions which deviate strongly from the zero-coupling limit, even when the coupling is rather weak. The Fourier transforms of these response functions and the corresponding ColeCole diagrams are constructed and discussed as well.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Hip and knee pain in a child with bacteremic pneumococcal pneumonia and empyema.

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