4 research outputs found
An automatic analysis framework for FDOPA PET neuroimaging
In this study we evaluate the performance of a fully automated analytical framework for FDOPA PET neuroimaging data, and its sensitivity to demographic and experimental variables and processing parameters. An instance of XNAT imaging platform was used to store the King's College London institutional brain FDOPA PET imaging archive, alongside individual demographics and clinical information. By re-engineering the historical Matlab-based scripts for FDOPA PET analysis, a fully automated analysis pipeline for imaging processing and data quantification was implemented in Python and integrated in XNAT. The final data repository includes 892 FDOPA PET scans organized from 23 different studies. We found good reproducibility of the data analysis by the automated pipeline (in the striatum for the Kicer: for the controls ICC = 0.71, for the psychotic patients ICC = 0.88). From the demographic and experimental variables assessed, gender was found to most influence striatal dopamine synthesis capacity (F = 10.7, p < 0.001), with women showing greater dopamine synthesis capacity than men. Our automated analysis pipeline represents a valid resourse for standardised and robust quantification of dopamine synthesis capacity using FDOPA PET data. Combining information from different neuroimaging studies has allowed us to test it comprehensively and to validate its replicability and reproducibility performances on a large sample size
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Products liability.
The goal of this Products Liability IQP is to learn the basic concepts of products liability law. First, in order to gain a fundamental understanding of the topic, we watched nine videos and read a book pertaining to the topic. Using this as a foundation to work from, we analyzed four liability cases, three of which were product liability cases and one of which was an accident reconstruction. This experience expanded our knowledge of safety standards, the responsibility of management and engineering analysis techniques
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Design of a microjet flow system
This project designed an experimental setup for the investigation of microjets and their impingement on flexible structures. The flow system includes a pressurized gas tank, pressure regulators, a filter, a mass-flow measuring tank, and a micro-nozzle. Continuum and free-molecular theory is used for the design of micro-nozzles with a throat diameter as small as 10 micrometers and reservoir pressures between 100 and 1000 Pa. A mass-flow measuring technique based on pressure-decay is developed for rates as small as 10E-13 kg/s