Together

Many struggles are now becoming visible. And many self-motivated people motivate me, in turn, to address problems. Unpaid activist work is a double burden. The work is exhausting and looking the imbalances one sees squarely in the eye is demanding. But unpaid activist work also has its own compensation. It helps me to escape powerlessness. Swallowing something down certainly avoids the immediate fury—but it leaves me helpless and alone, and I really just can’t with that.It’s necessary to connect many different struggles. Because then it’s suddenly about a better life for everyone. There’s always something to do. This is overwhelming. But there are also always people with whom one can do it together. And that empowers

Molecular identification of different trypanosome species and subspecies in tsetse flies of northern Nigeria

Background: Animal African Trypanosomiasis (AAT) is caused by several species of trypanosomes including Trypanosoma congolense, T. vivax, T. godfreyi, T. simiae and T. brucei. Two of the subspecies of T. brucei also cause Human African Trypanosomiasis. Although some of them can be mechanically transmitted by biting flies; these trypanosomes are all transmitted by tsetse flies which are the cyclical vectors of Trypanosoma congolense, T. godfreyi, T. simiae and T. brucei. We present here the first report assessing the prevalence of trypanosomes in tsetse flies in Nigeria using molecular tools. Methods: 488 tsetse flies of three species, Glossina palpalis palpalis, G. tachinoides and G. morsitans submorsitans were collected from Wuya, Niger State and Yankari National Park, Bauchi State in 2012. Trypanosomes were detected and identified using an ITS1 PCR assay on DNA purified from the ‘head plus proboscis’ (H + P) and abdomen (ABD) parts of each fly. Results: T. vivax and T. congolense Savannah were the major parasites detected. Trypanosomes prevalence was 7.1 % in G. p. palpalis, 11.9 % in G. tachinoides and 13.5 % in G. m. submorsitans. Prevalences of T. congolense Savannah ranged from 2.5 to 6.7 % and of T. vivax were approximately 4.5 %. Trypanosoma congolense Forest, T. godfreyi and T. simiae were also detected in the site of Yankari. The main biological and ecological determinants of trypanosome prevalence were the fly sex, with more trypanosomes found in females than males, and the site, with T. congolense subspp. being more abundant in Yankari than in Wuya. As expected, the trypanosome species diversity was higher in Yankari National Park than in the more agricultural site of Wuya where vertebrate host species diversity is lower. Conclusions: Our results show that T. congolense Savannah and T. vivax are the main species of parasite potentially causing AAT in the two study sites and that Yankari National Park is a potential reservoir of trypanosomes both in terms of parasite abundance and species diversity

Assessment of socio-techno-economic factors affecting the market adoption and evolution of 5G networks: Evidence from the 5G-PPP CHARISMA project

5G networks are rapidly becoming the means to accommodate the complex demands of vertical sectors. The European project CHARISMA is aiming to develop a hierarchical, distributed-intelligence 5G architecture, offering low latency, security, and open access as features intrinsic to its design. Finding its place in such a complex landscape consisting of heterogeneous technologies and devices, requires the designers of the CHARISMA and other similar 5G architectures, as well as other related market actors to take into account the multiple technical, economic and social aspects that will affect the deployment and the rate of adoption of 5G networks by the general public. In this paper, a roadmapping activity identifying the key technological and socio-economic issues is performed, so as to help ensure a smooth transition from the legacy to future 5G networks. Based on the fuzzy Analytical Hierarchy Process (AHP) method, a survey of pairwise comparisons has been conducted within the CHARISMA project by 5G technology and deployment experts, with several critical aspects identified and prioritized. The conclusions drawn are expected to be a valuable tool for decision and policy makers as well as for stakeholders

GPS DEFORMATION MEASUREMENTS IN THE GEODYNAMIC TEST NETWORK SÓSKÚT

The Geodetic Institute of the University of Karlsruhe and the Department of Geodesy and Surveying of the Budapest University of Technology and Economics have been cooperating for 30 years in the field of deformation measurements and analysis. One of the common projects in this cooperation is related to the network of Sóskút which has been established to detect surface motions in the vicinity of a geological fracture. In the beginning terrestrial measurements have been carried out, while in recent years common GPS campaigns were organized in order to investigate the potential of the GPS technology in deformation measurements and analysis. The paper describes the development and the actual results of the joint project and points out the progress in methodology

The Grizzly, February 9, 1998

Privacy Invaded at Centennial Conference College • Changing Homecoming • Mother Courage Takes the Stage • Wismer Center to Receive Renovations with New Bookstore • Letters to the Editor • Journalist Visits Ursinus • Greeks Help a Special Friend • Ursinus Faculty Remembers When... • Jazzing up the Curriculum • Ladies\u27 Night for UC Swimming • Women\u27s Basketball Holds Off Muhlenberg • Barrett Looks to Guide Bears to Playoffs • Bears Stumble but Remain in Playoff Hunt • Ursinus Gymnasts Consistent Through Tough Competition • Wrestlers Suffer Second Loss of Seasonhttps://digitalcommons.ursinus.edu/grizzlynews/1413/thumbnail.jp

Social factors affecting seasonal variation in bovine trypanosomiasis on the Jos Plateau, Nigeria

BACKGROUND: African Animal Trypanosomiasis (AAT) is a widespread disease of livestock in Nigeria and presents a major constraint to rural economic development. The Jos Plateau was considered free from tsetse flies and the trypanosomes they transmit due to its high altitude and this trypanosomiasis free status attracted large numbers of cattle-keeping pastoralists to the area. The Jos Plateau now plays a major role in the national cattle industry in Nigeria, accommodating approximately 7% of the national herd, supporting 300,000 pastoralists and over one million cattle. During the past two decades tsetse flies have invaded the Jos Plateau and animal trypanosomiasis has become a significant problem for livestock keepers. Here we investigate the epidemiology of trypanosomiasis as a re-emerging disease on the Plateau, examining the social factors that influence prevalence and seasonal variation of bovine trypanosomiasis. METHODS: In 2008 a longitudinal two-stage cluster survey was undertaken on the Jos Plateau. Cattle were sampled in the dry, early wet and late wet seasons. Parasite identification was undertaken using species-specific polymerase chain reactions to determine the prevalence and distribution of bovine trypanosomiasis. Participatory rural appraisal was also conducted to determine knowledge, attitudes and practices concerning animal husbandry and disease control. RESULTS: Significant seasonal variation between the dry season and late wet season was recorded across the Jos Plateau, consistent with expected variation in tsetse populations. However, marked seasonal variations were also observed at village level to create 3 distinct groups: Group 1 in which 50% of villages followed the general pattern of low prevalence in the dry season and high prevalence in the wet season; Group 2 in which 16.7% of villages showed no seasonal variation and Group 3 in which 33.3% of villages showed greater disease prevalence in the dry season than in the wet season. CONCLUSIONS: There was high seasonal variation at the village level determined by management as well as climatic factors. The growing influence of management factors on the epidemiology of trypanosomiasis highlights the impact of recent changes in land use and natural resource competition on animal husbandry decisions in the extensive pastoral production system

Bolaamphiphile Analogues of 12-bis-THA Cl2 Are Potent Antimicrobial Therapeutics with Distinct Mechanisms of Action against Bacterial, Mycobacterial, and Fungal Pathogens

12-Bis-THA Cl2 [12,12'-(dodecane-1,12-diyl)-bis-(9-amino-1,2,3,4-tetrahydroacridinium) chloride] is a cationic bolalipid adapted from dequalinium chloride (DQC), a bactericidal anti-infective indicated for bacterial vaginosis (BV). Here, we used a structure-activity-relationship study to show that the factors that determine effective killing of bacterial, fungal, and mycobacterial pathogens differ, to generate new analogues with a broader spectrum of activity, and to identify synergistic relationships, most notably with aminoglycosides against Acinetobacter baumannii and Pseudomonas aeruginosa, where the bactericidal killing rate was substantially increased. Like DQC, 12-bis-THA Cl2 and its analogues accumulate within bacteria and fungi. More hydrophobic analogues with larger headgroups show reduced potential for DNA binding but increased and broader spectrum antibacterial activity. In contrast, analogues with less bulky headgroups and stronger DNA binding affinity were more active against Candida spp. Shortening the interconnecting chain, from the most lipophilic twelve-carbon chain to six, improved the selectivity index against Mycobacterium tuberculosis in vitro, but only the longer chain analogue was therapeutic in a Galleria mellonella infection model, with the shorter chain analogue exacerbating the infection. In vivo therapy of Escherichia coli ATCC 25922 and epidemic methicillin-resistant Staphylococcus aureus 15 (EMRSA-15) infections in Galleria mellonella was also achieved with longer-chain analogues, as was therapy for an A. baumannii 17978 burn wound infection with a synergistic combination of bolaamphiphile and gentamicin. The present study shows how this class of bolalipids may be adapted further to enable a wider range of potential applications. IMPORTANCE While we face an acute threat from antibiotic resistant bacteria and a lack of new classes of antibiotic, there are many effective antimicrobials which have limited application due to concerns regarding their toxicity and which could be more useful if such risks are reduced or eliminated. We modified a bolalipid antiseptic used in throat lozenges to see if it could be made more effective against some of the highest-priority bacteria and less toxic. We found that structural modifications that rendered the lipid more toxic against human cells made it less toxic in infection models and we could effectively treat caterpillars infected with either Mycobacterium tuberculosis, methicillin resistant Staphylococcus aureus, or Acinetobacter baumannii. The study provides a rationale for further adaptation toward diversifying the range of indications in which this class of antimicrobial may be used

"We have no voice for that" : Land Rights, Power, and Gender in Rural Sierra Leone

Acknowledgements I wish to thank the participants in the Gender and Land Governance Conference at Utrecht University in January 2013 for helpful comments and suggestions. Funding I would like to thank the Faculty of Management at Radboud University Nijmegen for funding the six months of fieldwork on which this article is based.Peer reviewedPostprin