43 research outputs found
New Experimental Limits on Macroscopic Forces Below 100 Microns
Results of an experimental search for new macroscopic forces with Yukawa
range between 5 and 500 microns are presented. The experiment uses 1 kHz
mechanical oscillators as test masses with a stiff conducting shield between
them to suppress backgrounds. No signal is observed above the instrumental
thermal noise after 22 hours of integration time. These results provide the
strongest limits to date between 10 and 100 microns, improve on previous limits
by as much as three orders of magnitude, and rule out half of the remaining
parameter space for predictions of string-inspired models with low-energy
supersymmetry breaking. New forces of four times gravitational strength or
greater are excluded at the 95% confidence level for interaction ranges between
200 and 500 microns.Comment: 25 Pages, 7 Figures: Minor Correction
Engineered 2D Ising interactions on a trapped-ion quantum simulator with hundreds of spins
The presence of long-range quantum spin correlations underlies a variety of
physical phenomena in condensed matter systems, potentially including
high-temperature superconductivity. However, many properties of exotic strongly
correlated spin systems (e.g., spin liquids) have proved difficult to study, in
part because calculations involving N-body entanglement become intractable for
as few as N~30 particles. Feynman divined that a quantum simulator - a
special-purpose "analog" processor built using quantum particles (qubits) -
would be inherently adept at such problems. In the context of quantum
magnetism, a number of experiments have demonstrated the feasibility of this
approach. However, simulations of quantum magnetism allowing controlled,
tunable interactions between spins localized on 2D and 3D lattices of more than
a few 10's of qubits have yet to be demonstrated, owing in part to the
technical challenge of realizing large-scale qubit arrays. Here we demonstrate
a variable-range Ising-type spin-spin interaction J_ij on a naturally occurring
2D triangular crystal lattice of hundreds of spin-1/2 particles (9Be+ ions
stored in a Penning trap), a computationally relevant scale more than an order
of magnitude larger than existing experiments. We show that a spin-dependent
optical dipole force can produce an antiferromagnetic interaction J_ij ~
1/d_ij^a, where a is tunable over 0<a<3; d_ij is the distance between spin
pairs. These power-laws correspond physically to infinite-range (a=0),
Coulomb-like (a=1), monopole-dipole (a=2) and dipole-dipole (a=3) couplings.
Experimentally, we demonstrate excellent agreement with theory for 0.05<a<1.4.
This demonstration coupled with the high spin-count, excellent quantum control
and low technical complexity of the Penning trap brings within reach simulation
of interesting and otherwise computationally intractable problems in quantum
magnetism.Comment: 10 pages, 10 figures; article plus Supplementary Material
HLA genotyping in the international Type 1 Diabetes Genetics Consortium
Background Although human leukocyte antigen (HLA) DQ and
DR loci appear to confer the strongest genetic risk for
type 1 diabetes, more detailed information is required for other loci within the
HLA region to understand causality and stratify additional risk factors. The
Type 1 Diabetes Genetics Consortium (T1DGC) study design included
high-resolution genotyping of HLA-A, B,
C, DRB1, DQ, and
DP loci in all affected sibling pair and trio families, and
cases and controls, recruited from four networks worldwide, for analysis with
clinical phenotypes and immunological markers
A Polymorphism in the HLA-DPB1 Gene Is Associated with Susceptibility to Multiple Sclerosis
We conducted an association study across the human leukocyte antigen (HLA) complex to identify loci associated with multiple sclerosis (MS). Comparing 1927 SNPs in 1618 MS cases and 3413 controls of European ancestry, we identified seven SNPs that were independently associated with MS conditional on the others (each ). All associations were significant in an independent replication cohort of 2212 cases and 2251 controls () and were highly significant in the combined dataset (). The associated SNPs included proxies for HLA-DRB1*15:01 and HLA-DRB1*03:01, and SNPs in moderate linkage disequilibrium (LD) with HLA-A*02:01, HLA-DRB1*04:01 and HLA-DRB1*13:03. We also found a strong association with rs9277535 in the class II gene HLA-DPB1 (discovery set , replication set , combined ). HLA-DPB1 is located centromeric of the more commonly typed class II genes HLA-DRB1, -DQA1 and -DQB1. It is separated from these genes by a recombination hotspot, and the association is not affected by conditioning on genotypes at DRB1, DQA1 and DQB1. Hence rs9277535 represents an independent MS-susceptibility locus of genome-wide significance. It is correlated with the HLA-DPB1*03:01 allele, which has been implicated previously in MS in smaller studies. Further genotyping in large datasets is required to confirm and resolve this association
Unconventional structure-assisted optical manipulation of high-index nanowires in liquid crystals
Stable optical trapping and manipulation of high-index particles in low-index host media is often impossible due to the dominance of scattering forces over gradient forces. Here we explore optical manipulation in liquid crystalline structured hosts and show that robust optical manipulation of high-index particles, such as GaN nanowires, is enabled by laser-induced distortions in long-range molecular alignment, via coupling of translational and rotational motions due to helicoidal molecular arrangement, or due to elastic repulsive interactions with confining substrates. Anisotropy of the viscoelastic liquid crystal medium and particle shape give rise to a number of robust unconventional trapping capabilities, which we use to characterize defect structures and study rheological properties of various thermotropic liquid crystals