The Force Exerted by a Molecular Motor

The stochastic driving force exerted by a single molecular motor (e.g., a kinesin, or myosin) moving on a periodic molecular track (microtubule, actin filament, etc.) is discussed from a general viewpoint open to experimental test. An elementary "barometric" relation for the driving force is introduced that (i) applies to a range of kinetic and stochastic models, (ii) is consistent with more elaborate expressions entailing explicit representations of externally applied loads and, (iii) sufficiently close to thermal equilibrium, satisfies an Einstein-type relation in terms of the velocity and diffusion coefficient of the (load-free) motor. Even in the simplest two-state models, the velocity-vs.-load plots exhibit a variety of contrasting shapes (including nonmonotonic behavior). Previously suggested bounds on the driving force are shown to be inapplicable in general by analyzing discrete jump models with waiting time distributions.Comment: submitted to PNA

Extended Kinetic Models with Waiting-Time Distributions: Exact Results

Inspired by the need for effective stochastic models to describe the complex behavior of biological motor proteins that move on linear tracks exact results are derived for the velocity and dispersion of simple linear sequential models (or one-dimensional random walks) with general waiting-time distributions. The concept of ``mechanicity'' is introduced in order to conveniently quantify departures from simple ``chemical,'' kinetic rate processes, and its significance is briefly indicated. The results are extended to more elaborate models that have finite side-branches and include death processes (to represent the detachment of a motor from the track).Comment: 17 pages, 2 figure

Lattice Models of Ionic Systems

A theoretical analysis of Coulomb systems on lattices in general dimensions is presented. The thermodynamics is developed using Debye-Huckel theory with ion-pairing and dipole-ion solvation, specific calculations being performed for 3D lattices. As for continuum electrolytes, low-density results for sc, bcc and fcc lattices indicate the existence of gas-liquid phase separation. The predicted critical densities have values comparable to those of continuum ionic systems, while the critical temperatures are 60-70% higher. However, when the possibility of sublattice ordering as well as Debye screening is taken into account systematically, order-disorder transitions and a tricritical point are found on sc and bcc lattices, and gas-liquid coexistence is suppressed. Our results agree with recent Monte Carlo simulations of lattice electrolytes.Comment: 25 pages, 3 figures, ReVTeX 4, Submitted to J. Chem. Phy

IRAS versus POTENT Density Fields on Large Scales: Biasing and Omega

The galaxy density field as extracted from the IRAS 1.2 Jy redshift survey is compared to the mass density field as reconstructed by the POTENT method from the Mark III catalog of peculiar velocities. The reconstruction is done with Gaussian smoothing of radius 12 h^{-1}Mpc, and the comparison is carried out within volumes of effective radii 31-46 h^{-1}Mpc, containing approximately 10-26 independent samples. Random and systematic errors are estimated from multiple realizations of mock catalogs drawn from a simulation that mimics the observed density field in the local universe. The relationship between the two density fields is found to be consistent with gravitational instability theory in the mildly nonlinear regime and a linear biasing relation between galaxies and mass. We measure beta = Omega^{0.6}/b_I = 0.89 \pm 0.12 within a volume of effective radius 40 h^{-1}Mpc, where b_I is the IRAS galaxy biasing parameter at 12 h^{-1}Mpc. This result is only weakly dependent on the comparison volume, suggesting that cosmic scatter is no greater than \pm 0.1. These data are thus consistent with Omega=1 and b_I\approx 1. If b_I>0.75, as theoretical models of biasing indicate, then Omega>0.33 at 95% confidence. A comparison with other estimates of beta suggests scale-dependence in the biasing relation for IRAS galaxies.Comment: 35 pages including 10 figures, AAS Latex, Submitted to The Astrophysical Journa

Vectorial Loading of Processive Motor Proteins: Implementing a Landscape Picture

Individual processive molecular motors, of which conventional kinesin is the most studied quantitatively, move along polar molecular tracks and, by exerting a force ${\bm F} = (F_x,F_y,F_z)$ on a tether, drag cellular cargoes, {\em in vivo}, or spherical beads, {\em in vitro}, taking up to hundreds of nanometer-scale steps. From observations of velocities and the dispersion of displacements with time, under measured forces and controlled fuel supply (typically ATP), one may hope to obtain insight into the molecular motions undergone in the individual steps. In the simplest situation, the load force ${\bm F}$ may be regarded as a scalar resisting force, $F_x < 0$, acting parallel to the track: however, experiments, originally by Gittes {\em et al.} (1996), have imposed perpendicular (or vertical) loads, $F_z > 0$, while more recently Block and coworkers (2002, 2003) and Carter and Cross (2005) have studied {\em assisting} (or reverse) loads, $F_x > 0$, and also sideways (or transverse) loads $F_y \neq 0$

Scaling for Interfacial Tensions near Critical Endpoints

Parametric scaling representations are obtained and studied for the asymptotic behavior of interfacial tensions in the \textit{full} neighborhood of a fluid (or Ising-type) critical endpoint, i.e., as a function \textit{both} of temperature \textit{and} of density/order parameter \textit{or} chemical potential/ordering field. Accurate \textit{nonclassical critical exponents} and reliable estimates for the \textit{universal amplitude ratios} are included naturally on the basis of the ``extended de Gennes-Fisher'' local-functional theory. Serious defects in previous scaling treatments are rectified and complete wetting behavior is represented; however, quantitatively small, but unphysical residual nonanalyticities on the wetting side of the critical isotherm are smoothed out ``manually.'' Comparisons with the limited available observations are presented elsewhere but the theory invites new, searching experiments and simulations, e.g., for the vapor-liquid interfacial tension on the two sides of the critical endpoint isotherm for which an amplitude ratio $-3.25 \pm 0.05$ is predicted.Comment: 42 pages, 6 figures, to appear in Physical Review

Using Cluster Abundances and Peculiar Velocities to Test the Gaussianity of the Cosmological Density Field

(Abridged) By comparing the frequency of typical events with that of unusual events, one can test whether the cosmological density distribution function is consistent with the normally made assumption of Gaussianity. To this end, we compare the consistency of the tail-inferred (from clusters) and measured values (from large-scale flows) of the rms level of mass fluctuations for two distribution functions: a Gaussian, and a texture (positively-skewed) PDF. Averaging the recent large-scale flow measurements, we find that observations of the rms and the tail at the 10 h^-1 Mpc scale disfavor a texture PDF at ~1.5 sigma in all cases. However, taking only the most recent measurement of the rms, that from Willick et al. (1997b), the comparison disfavors textures for low Omega_0=0.3, and disfavors Gaussian models if Omega_0=1 (again at ~1.5 sigma). Predictions for evolution of high temperature clusters can also be made for the models considered, and strongly disfavor Omega_0=1 in Gaussian models and marginally disfavor Omega_0=1 in texture models. Only Omega_0=0.3 Gaussian models are consistent with all the data considered.Comment: 34 pg incl. 8 embedded figures, LaTeX, aaspp4.sty, submitted to Ap

Gapless layered three-dimensional fractional quantum Hall states

Using the parton construction, we build a three-dimensional (3D) multilayer fractional quantum Hall state with average filling \nu = 1/3 per layer that is qualitatively distinct from a stacking of weakly coupled Laughlin states. The state supports gapped charge e/3 fermionic quasiparticles that can propagate both within and between the layers, in contrast to the quasiparticles in a multilayer Laughlin state which are confined within each layer. Moreover, the state has gapless neutral collective modes, a manifestation of an emergent "photon", which is minimally coupled to the fermionic quasiparticles. The surface sheath of the multilayer state resembles a chiral analog of the Halperin-Lee-Read state, which is protected against gap forming instabilities by the topological character of the bulk 3D phase. We propose that this state might be present in multilayer systems in the "intermediate tunneling regime", where the interlayer tunneling strength is on the same order as the Coulomb energy scale. We also find that the parton construction leads to a candidate state for a bilayer \nu = 1/3 system in the intermediate tunneling regime. The candidate state is distinct from both a bilayer of \nu=1/3 Laughlin states and the single layer \nu = 2/3 state, but is nonetheless a fully gapped fractional quantum Hall state with charge e/3 anyonic quasiparticles.Comment: 11 pages, 1 figur

Sweetening the Till: The Use of Candy to Increase Restaurant Tipping

A common practice among servers in restaurants is to give their dining parties an unexpected gift in the form of candy when delivering the check. Two studies were conducted to evaluate the impact of this gesture on the tip percentages received by servers. Study 1 found that customers who received a small piece of chocolate along with the check tipped more than did customers who received no candy. Study 2 found that tips varied with the amount of the candy given to the customers as well as with the manner in which it was offered. It is argued that reciprocity is a stronger explanation for these findings than either impression management or the good mood effect

Determination of the Baryon Density from Large Scale Galaxy Redshift Surveys

We estimate the degree to which the baryon density, $\Omega_{b}$, can be determined from the galaxy power spectrum measured from large scale galaxy redshift surveys, and in particular, the Sloan Digital Sky Survey. A high baryon density will cause wiggles to appear in the power spectrum, which should be observable at the current epoch. We assume linear theory on scales $\geq 20h^{-1}Mpc$ and do not include the effects of redshift distortions, evolution, or biasing. With an optimum estimate of $P(k)$ to $k\sim 2\pi/(20 h^{-1} Mpc)$, the $1 \sigma$ uncertainties in $\Omega_{b}$ are roughly 0.07 and 0.016 in flat and open ($\Omega_{0}=0.3$) cosmological models, respectively. This result suggests that it should be possible to test for consistency with big bang nucleosynthesis estimates of $\Omega_{b}$ if we live in an open universe.Comment: 23 Pages, 10 Postscript figure