Melt-extruded polyethylene oxide (PEO) rods as drug delivery vehicles: Formulation, performance as controlled release devices and the influence of co-extruded excipients on drug release profiles

The utility of controlled release medication formulations lies in their ability to keep drugs at steady levels in the blood plasma of recipients and within the termini of the maximum and minimum effective therapeutic levels. This avoids the “ups” and “downs” of medication levels within the body which would have been the result had conventional immediate release tablets been administered instead. In the veterinary field, controlled release medications are essential¹ because of the logistical difficulties of administering drugs on a regular (e.g., daily) basis to animals. The chief advantages of controlled release veterinary medications lie in the ease with which they can be administered; decrease in stress for animals, owing to less need for rounding up and frequent dosing; and, most importantly for farmers, the reduced cost of treatment relative to that for a multiple dosage regime

Effects of moderate abundance changes on the atmospheric structure and colours of Mira variables (Research Note)

Aims. We study the effects of moderate deviations from solar abundances upon the atmospheric structure and colours of typical Mira variables. Methods. We present two model series of dynamical opacity-sampling models of Mira variables which have (1) 1 solar metallicity 3 and (2) "mild" S-type C/O abundance ratio ([C/O]=0.9) with typical Zr enhancement (solar +1.0). These series are compared to a previously studied solar-abundance series which has similar fundamental parameters (mass, luminosity, period, radius) that are close to those of o Cet. Results. Both series show noticeable effects of abundance upon stratifications and infrared colours but cycle-to-cycle differences mask these effects at most pulsation phases, with the exception of a narrow-water-filter colour near minimum phase.Comment: 4 pages, 3 figures, accepted for A&

A simple linear-time algorithm for finding path-decompositions of small width

We described a simple algorithm running in linear time for each fixed constant $k$, that either establishes that the pathwidth of a graph $G$ is greater than $k$, or finds a path-decomposition of $G$ of width at most $O(2^{k})$. This provides a simple proof of the result by Bodlaender that many families of graphs of bounded pathwidth can be recognized in linear time.Comment: 9 page

Obstructions to within a few vertices or edges of acyclic

Finite obstruction sets for lower ideals in the minor order are guaranteed to exist by the Graph Minor Theorem. It has been known for several years that, in principle, obstruction sets can be mechanically computed for most natural lower ideals. In this paper, we describe a general-purpose method for finding obstructions by using a bounded treewidth (or pathwidth) search. We illustrate this approach by characterizing certain families of cycle-cover graphs based on the two well-known problems: $k$-{\sc Feedback Vertex Set} and $k$-{\sc Feedback Edge Set}. Our search is based on a number of algorithmic strategies by which large constants can be mitigated, including a randomized strategy for obtaining proofs of minimality.Comment: 16 page

Relationship between physical capacity and match performance in semiprofessional Australian rules football

This study investigated the relationship between physical performance and match performance in Australian Rules Football (ARF). Thirty-six semiprofessional ARF players participated in this study. Physical capacity was measured using a 3-km time trial. Match performance was measured throughout the 2013 season through 2 methods: direct game involvements (DGIs) per minute and a recording of coaches\u27 vote after the game. The main finding of the study was that 3-km time trial performance was a significant predictor of DGI per minute (p ≤ 0.05). In addition, the number of senior games played was also significant in predicting DGI per minute (p ≤ 0.05). Furthermore, the number of senior games significantly correlated with coaches\u27 votes (p ≤ 0.05). There were no significant relationships between 3-km time trial and coaches\u27 vote. The results highlight the importance of developing physical capacity in the preseason period; the players who were better performers in the 3-km time trial had a greater number of DGIs per minute. This information is important to consider in preseason planning to ensure sufficient time is dedicated to developing physical capacity in the training program, as it is directly associated with performance. In addition, this research also highlights the importance of playing experience in relation to team selection. Playing experience, as measured by the number of senior games played, had a significant relationship with both measures of match performance

Biomedicals from Bone

The realm of biomaterials, under which biomedical materials can be categorised, has a broad definition base and recognises materials that are synthesized or naturally sourced. Biomaterials are normally those that come into contact with live tissue and physiological fluids. They have applications as prostheses to replace lost function of joints or to replace bone tissue, for diagnosing medical conditions, as a form of therapy, or as a storage unit. The diversity and scope of biomaterials science research, and especially its application to the improvement of trauma, disease, and congenital defects in the human condition, are making this branch of science increasingly dominant and topical in many countries. An exciting aspect is that such research is interdisciplinary. The varied problems of the human condition that biomaterials research addresses occupy the efforts not only of medical doctors who act as the end users of such technology, but also those of chemists, physicists, engineers, and biologists in creating the technological advances. Chemistry, in particular, plays a major role in such research, after all it is the foundation stone on which biomaterials polymer science and biomedical scaffold materials are built

Interview with John Roger Stemen, June 26, 2001

John Roger Stemen was interviewed on June 26, 2001 by Michael J. Birkner about his experiences before he became a professor of History at Gettysburg College. He discusses his childhood in Indiana and focuses on his undergraduate education at Yale University and his service in the photolithography unit in Korea. After the war he attended Indiana University and Johns Hopkins University, where he obtained his doctorate. Collection Note: This oral history was selected from the Oral History Collection maintained by Special Collections & College Archives. Transcripts are available for browsing in the Special Collections Reading Room, 4th floor, Musselman Library. GettDigital contains the complete listing of oral histories done from 1978 to the present. To view this list and to access selected digital versions please visit -- http://gettysburg.cdmhost.com/cdm/landingpage/collection/p16274coll

New results for the degree/diameter problem

The results of computer searches for large graphs with given (small) degree and diameter are presented. The new graphs are Cayley graphs of semidirect products of cyclic groups and related groups. One fundamental use of our ``dense graphs'' is in the design of efficient communication network topologies.Comment: 15 page