The use of dynamic sentinel node biopsy in case of penile cancer. A case report

Penile cancer is a rare disease with prevalence of approximately 1/100000 man in Europe. Well documented risk factors for a penile cancer are HPV Infection, phimosis, and chronic inflammation. Penile cancer is a curable condition when diagnosed and treated promptly. The invasion of lymphatic system is one of the most important matters affecting long term survival. Proper evaluation and treatment of lymph nodes is a main goal when dealing with this condition. In patients with palpable lymph nodes lymphadenectomy is method of choice. When dealing with unpalpable lymph nodes and increased risk of micro-metastatic disease, invasive nodal staging is recommended. For this staging we can choose from Modified inguinal lymphadenectomy and Dynamic Sentinel Node Biopsy In this paper we would like to present a case report of patient with penile cancer, where due to TNM staging, Dynamic Sentinel Node Biopsy was implemented

Massive burn > 90% of body surface – case report

Severe burns are life-threatening injuries very difficult to heal. Multidisciplinary treatment is necessary due to complicated pathophysiological cascades induced by massive tissue destruction. Children and elderly people are especially endangered in being burnt. We present case of 73 years old woman with massive burn injury of >90% body surface

Structural and functional changes in the central nervous system in the course of anorexia nervosa

New achievements within structural and functional imaging of central nervous system offer a basis for better understanding of the mechanisms underlying many mental disorders. In everyday clinical practice, we encounter many difficulties in the therapy of eating disorders. They are caused by a complex psychopathological picture, varied grounds of the problems experienced by patients, often poor motivation for active participation in the treatment process, difficulties in communication between patients and therapeutic staff, and various biological conditions of eating disorders. In this paper, the latest reports on new concepts and methods of diagnosis and treatment of anorexia nervosa have been analyzed. The selection of the analyzed publications was based on the criteria taking into account the time of publication, the size of research cohorts, as well as the experience of research teams in the field of nutritional disorders, confirmed by the number of works and their citations. The work aims to spread current information on anorexia nervosa neurobiology that would allow for determining the brain regions involved in the regulation of food intake, and consequently that may be a potential place where neurobiochemical processes responsible for eating disorders occur. In addition, using modern methods of structural imaging, the authors want to show some of the morphometric variations, particularly within white matter, occurring in patients suffering from anorexia nervosa, as well as those evaluated with magnetoencephalography of processes associated with the neuronal processing of information related to food intake. For example as regards anorexia nervosa, it was possible to localize the areas associated with eating disorders and broaden our knowledge about the changes in these areas that cause and accompany the illness. The described in this paper research studies using diffusion MRI fiber tractography showed the presence of changes in the white matter pathways of the brain, especially in the corpus callosum, which indicate a reduced content of myelin. These changes probably reflect malnutrition, and directly represent the effect of lipid deficiency. This leads to a weakening of the structure, and even cell death. In addition, there are more and more reports that show the normal volume of brain cells in patients with long-term remission of anorexia. It was also shown that in patients in remission stage there are functional changes within the amygdala in response to a task not related symptomatologically with anorexia nervosa. The appearing in the scientific literature data stating that in patients with anorexia nervosa there is a reduced density of GFAP + cells of the hippocampus and increased expression of vimentin and nestin, is also worth noting

High serum procalcitonin concentration and dynamics of its changes as a prognostic factor of mortality

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