Quantification of propidium iodide delivery with millisecond electric pulses: A model study

A model study of propidium iodide delivery with millisecond electric pulses is presented; this work is a companion of the experimental efforts by Sadik et al. [1]. Both membrane permeabilization and delivery are examined with respect to six extra-cellular conductivities. The transmembrane potential of the permeabilized regions exhibits a consistent value, which corresponds to a bifurcation point in the pore-radius-potential relation. Both the pore area density and membrane conductance increase with an increasing extra-cellular conductivity. On the other hand, the inverse correlation between propidium iodide delivery and extra-cellular conductivity as observed in the experiments is quantitatively captured by the model. This agreement confirms that this behavior is primarily mediated by electrophoretic transport during the pulse. The results suggest that electrophoresis is important even for the delivery of small molecules such as propidium iodide. The direct comparison between model prediction and experimental data presented in this work helps validate the former as a robust predictive tool for the study of electroporation

Hedging, financing, and investment decisions: a simultaneous equations framework

The purpose of this paper is to empirically investigate the interaction between hedging, financing, and investment decisions. This work is relevant in that theoretical predictions are not necessarily identical to those in the case where only two decisions are being made. We argue that the way in which hedging affects the firms’ financing and investing decisions differs for firms with different growth opportunities. We empirically find that high-growth firms increase their investment, but not their leverage, by hedging. However, we also find that firms with few investment opportunities use derivatives to increase their leverage.

From the lucky land to the beautiful country: Illegal immigration of Fujianese to the United States

It is puzzling why Fujianese are willing to pay seventy thousand dollars, which could entitle them to a comfortable life in China, to be smuggled to the United States. Despite the voluminous body of research, the life of Fujianese illegal immigrants has not been systematically explored. This study confirmed that people smuggling is a phenomenon that combines cultural, economic, and political factors. Furthermore, Fujianese who came to seek an American dream have lost something much more valuable than what they have gained, such as their youth and family connections. In addressing the smuggling strategies, causes, and experiences of Fujianese immigrants, this thesis has relied on interviews with former illegal immigrants from Fujian Province, China, as well as literature reviews. The respondents in this study are average people among tens of thousands of illegal immigrants. Their true stories provide a vivid picture of Fujianese emigration