The Study On The Effects Of Organizational Members Job Burnout

The rapidity with which the concept of job burnout has been incorporated into everyone's life is astonishing. During the two decades, many organizational members had been experienced job stresses. Because of chromic job stresses, they have fallen into job burnout. Generally speaking, Job burnout is a prolonged response to chronic emotional and interpersonal stressors on the job, and is defined by the three dimensions of emotional exhaustion, depersonalization, and reduced personal accomplishment. But there are not enough studies about a profession outside human service. In this point of view, this study examines the effect of organizational member's job burnout on job performance and what are the major antecedents of job burnout. Also the present study is designed to test the moderating effect of supervisor's support, job discretion, and self-esteem on relationship between role overload and role conflict and members' job burnout.   The purposes of this study are as follows;  First of all, this study purposed to examine the factors which affect the organizational members’ job burnout.  Secondly, this study was to examine the effect of the members' job burnout on job performance. Thirdly, this study aimed to test moderating effect of supervisor's support, job discretion, and self-esteem on relationship between role overload and role conflict and the members' job burnout.  For the practical analysis, 100 structured questionnaires were distributed to Korean employees in Korean employees in Busan, and Gyeongnam, Korea. 100 questionnaires were distributed and 100 were returned. However, 3 questionnaires out of those returned were considered to be statistically valueless for analysis since some questions were left unanswered and some were clearly biased. Therefore, a total of 97 questionnaires were used for analysis. The collected data has been analyzed by using SPSS 12.0 for windows. The statistical techniques used in this study were descriptive analysis, reliability test, factor analysis, discriminate analysis, correlation analysis, multi regression analysis, and hierarchical regression analysis.  The major findings of the study are as follows;  First of all, role overload and role conflict are shown to be the major antecedents of job burnout, particularly of the exhaustion and disengagement components. Secondly, the disengagement of job burnout was related to lower levels of job performance.  Thirdly, moderating effect of supervisor's support on the relationship between role overload and the members of exhaustion was statistically significant. But moderating effect of job performance and self-esteem was not significant

Recital: Korea\u27s Kim Trio: Won-Mi Kim, Piano; Won-Joo Kim, Violin; Won-Hee Kim, Cello; September 3, 1974

Centennial East Recital HallTuesday EveningSeptember 3, 19748:15 p.m

Human Neural Stem Cells Genetically Modified to Overexpress Akt1 Provide Neuroprotection and Functional Improvement in Mouse Stroke Model

In a previous study, we have shown that human neural stem cells (hNSCs) transplanted in brain of mouse intracerebral hemorrhage (ICH) stroke model selectively migrate to the ICH lesion and induce behavioral recovery. However, low survival rate of grafted hNSCs in the brain precludes long-term therapeutic effect. We hypothesized that hNSCs overexpressing Akt1 transplanted into the lesion site could provide long-term improved survival of hNSCs, and behavioral recovery in mouse ICH model. F3 hNSC was genetically modified with a mouse Akt1 gene using a retroviral vector. F3 hNSCs expressing Akt1 were found to be highly resistant to H2O2-induced cytotoxicity in vitro. Following transplantation in ICH mouse brain, F3.Akt1 hNSCs induced behavioral improvement and significantly increased cell survival (50–100% increase) at 2 and 8 weeks post-transplantation as compared to parental F3 hNSCs. Brain transplantation of hNSCs overexpressing Akt1 in ICH animals provided functional recovery, and survival and differentiation of grafted hNSCs. These results indicate that the F3.Akt1 human NSCs should be a great value as a cellular source for the cellular therapy in animal models of human neurological disorders including ICH

Notch1 intracellular domain suppresses APP intracellular domain—Tip60–Fe65 complex mediated signaling through physical interaction

AbstractThe amyloid beta-precursor protein (APP) and the Notch receptor are both type 1 integral transmembrane proteins, and both are cleaved by presenilin-dependent gamma-secretase activity. In this study, we have demonstrated that the Notch intracellular domain (Notch1-IC) suppresses APP-intracellular domain (AICD)-mediated ROS generation and cell death after being processed by gamma secretase. Notch1-IC physically interacts with AICD, Fe65, and Tip60, thereby disrupting the association of the AICD–Fe65–Tip60 trimeric transcription activator complex in AICD signaling. AICD–Fe65–Tip60 mediated reactive oxygen species generation was found to be suppressed by Notch1-IC. Furthermore, AICD–Fe65–Tip60 was shown to mediate cell death in human neuroblastoma cells, and the overexpression of Notch1-IC inhibited cell death induced by AICD–Fe65–Tip60. Collectively, our findings indicate that Notch1-IC plays the role of a negative regulator in AICD signaling via the disruption of the AICD–Fe65–Tip60 trimeric complex

ArrayXPath II: mapping and visualizing microarray gene-expression data with biomedical ontologies and integrated biological pathway resources using Scalable Vector Graphics

Summary: ArrayXPath () is a web-based service for mapping and visualizing microarray gene-expression data with integrated biological pathway resources using Scalable Vector Graphics (SVG). Deciphering the crosstalk among pathways and integrating biomedical ontologies and knowledge bases may help biological interpretation of microarray data. ArrayXPath is empowered by integrating gene-pathway, disease-pathway, drug-pathway and pathway–pathway correlations with integrated Gene Ontology, Medical Subject Headings and OMIM Morbid Map-based annotations. We applied Fisher's exact test and relative risk to evaluate the statistical significance of the correlations. ArrayXPath produces Javascript-enabled SVGs for web-enabled interactive visualization of gene-expression profiles integrated with gene-pathway-disease interactions enriched by biomedical ontologies