11 research outputs found
Malignant melanoma of the liver
Autori prikazuju sluÄaj Äetrdeset-trogodiÅ”nje bolesnice, obraÄivane zbog bolova desnog hemiabdomena, u trajanju dva mjeseca, i hepatomegalije. Glavni anamnestiÄki podatak bila je dijagnoza malignog melanoma lijevog oka i enukleacije tog oka prije jedanaest godina. PatoloÅ”ki testovi jetrene funkcije, posebno poveÄane vrijednosti AST, ALT, gama GT, alkalne fosfataze; te scintigrafija, ultrazvuk i CT nisu bili dovoljni za postavljanje dijagnoze. Perkutornom biopsijom jetre, pod kontrolom CT-a, postavljena je definitivna dijagnoza: metastaza
malignog melanoma.The case of a 43-year-old woman with two-month history of right hemiabdominal pain and hepatomegaly is presented. The main anamnestic data were the diagnosed left eye malignant melanoma and the enucleation of that eye 11 years ago. Abnormal results of the liver function tests, particularly elevated AST, ALT, gamma GT and alkaline phosphatase levels as well as scintiscan, ultrasound and CT could not provide a presumptive diagnosis. Percutaneous needle biopsy of the liver under CT control enabled the diagnosis of malignant melanoma metastases
Comparison of epidemiological characteristics of duodenal erosions and duopdenal ulcer
Na Internoj klinici Medicinskog fakulteta SveuÄiliÅ”ta u Zagrebu, OpÄe bolnice Osijek u razdoblju od 01. sijeÄnja 1987. do 31. prosinca 1989. godine napravljeno je 10209 ezofagogastroduodenoskopija i u 27,9% bolesnika naÄene su erozije, a peptiÄki ulkus u 48,9% bolesnika. Erozije su najÄeÅ”Äe bile locirane u duodenumu (38%), a 18% bolesnika imalo je erozije i u duodenumu i u antrumu. Erozije su naÄene u 24,9% bolesnika s peptiÄkim ulkusom. Duodenalne erozije naÄene su u 56% bolesnika s erozivnom boleÅ”Äu. Oko 40% bolesnika s duodenalnim erozijama imalo je i peptiÄki ulkus (duodenalni 37%, a želuÄani 3% bolesnika). Pojava ulkusne i/ili erozivne duodenalne bolesti najÄeÅ”Äa je u jesen (40%), a najrjeÄa ljeti (16%). Iz epidemioloÅ”ke analize 360 bolesnika, koji su bili podijeljeni u tri grupe s obzirom na to imaju li nezavisne duodenalne erozije, erozije i ulkus ili nezavisni duodenalni ulkus, proizlazi da prioritetan Å”tetan utjecaj na nezavisne duodenalne erozije ima neredovita, loÅ”a prehrana i pretjerana uporaba mirodija, dok brzo jedenje i/ili nedovoljno žvakanje hrane ima utjecaj na pojavu ulkusne bolesti. Postoji i mala povezanost izmeÄu slobodnih zanimanja i ulkusne bolesti, te izmeÄu erozivne bolesti i prekida radnog odnosa. OdreÄen utjecaj na udruženu erozivnu i ulkusnu patologiju imaju i psihoemocionalne komponente u obitelji, mjestu stanovanja i na radnom mjestu. Konzumiranje alkohola (125 g/dan i viÅ”e) ima viÅ”e utjecaja na pojavu erozija, a puÅ”enje cigareta (25/dan i viÅ”e) i pijenje crne kave (5 Å”alica/dan i viÅ”e) na pojavu duodenalne ulkusne bolesti. UoÄena je i veza izmeÄu uporabe lijekova koji oÅ”teÄuju sluznicu i nezavisne erozivne bolesti.In the period from January the 1st 1987, till December the 31st 1989, it was done 10209 endoscopy examinations on the Internal Clinic of General Hospital Osijek. In 27,9% of the patients erosions and in 48,9% of the patients peptic ulcer has been found. Erosive lesions were localized mainly in duodenum (38%) and in 18% of the cases erosive lesions were localized both in duodenum and in antrum. In 24,9% of the cases duodenal erosions coexist with ulcerative peptic disease (duodenal 37%, gasrtic 3%). The appearance of ulcer and/or erosive duodenal disease was mainly in autumn (40%) and less often in summer (16%). From an epidemiological study on 360 cases, which were divided into 3 groups: cases with autonomus duodenal erosive disease, those with erosions and ulcer and those with autonomous duodenal ulcer, we can see that in duodenal erosive disease predisposing factors are irregular, poor nutrition and excessive use of flavours, while fast eating and/or insufficiently chewing of the food are predisposing factors for ulcerative disease. Besides, there is a slight association between free-lance activity and ulcerative disease and between erosive disease and temporary or permanent interruption of work. The psycho-emotional component in family and work situations does have a determining effect on the erosive and ulcerative associated pathology. It is interesting to notice the relationship between erosive disease and abuse of alcohol (125 g/day or more) and between duodenal ulcerative disease and abuse of nicotine (25 cigarettes/day or more) and coffee (5 cups/day or more). Besides, it is notice the relationship between mucosa- damaging drugs and autonomous erosive disease
Epidemiological characteristic of duodenal erosions
Na Internoj klinici OpÄe bolnice Osijek uÄinjena je prospektivna studija gdje je napravljeno 3950 ezofagogastroduodenoskopija i u 238 bolesnika naÄene su duodenalne erozije. U 99 bolesnika one su bile udružene s peptiÄkim ulkusom. Bolesnici s duodenalnim erozijama (u obje grupe) bili su uglavnom u dobi od 30 do 59 godina. Omjer muÅ”karaca prema ženama u bolesnika s nezavisnim erozijama bio je 4,8:1, a u bolesnika koji su imali erozije udružene s peptiÄkim ulkusom 6,1:1. Duodenalne erozije su u 143 bolesnika diseminirane, a u 81 bolesnika zonalno rasporeÄene (uglavnom na prednjoj i stražnjoj stijenci). PojedinaÄne erozije naÄene su u 14 bolesnika. Pojava duodenalnih erozija u obje grupe bila je najÄeÅ”Äa u jesen, a najrjeÄa ljeti. Pojava konzumiranja alkoholnih piÄa, crne kave i puÅ”enja cigareta sliÄni su u bolesnika s duodenalnim erozijama i u opÄoj populaciji podvrgnutoj ezofagogastroÄuodenoskopiji. Ti rezultati pokazuju da su epidemioloÅ”ke karakteristike duodenalnih erozija dosta sliÄne onima kod duodenalnog ulkusa i zbog toga ova patologija treba biti ukljuÄena u Å”iroko poglavlje peptiÄke bolesti.In the prospective investigation on the Internal Clinic of General Hospital Osijek 3950 endoscopic examinations has been done and in 238 patients duodenal erosions has been found. In 99 patients duodenal erosions coexist with ulcerative peptic disease. The patients with duodenal erosions (in both groups) were predominantly between 30 and 59 years old. The ratio of men to woman in patients with autonomous erosions was 4,8:1, and in patients with erosions connected with ulcerative peptic disease was 6,1:1. In 143 patients duodenal erosions werde disseminated and in 81 patients were zonally disributed (mainly in the anterior and posterior walls). In 14 patients single erosions have been found. In both groups duodenal erosions were mainly observed in autumn, and rarely in summer. The intake of alcohol, coffe and cigarettes were quite similar in patients with duodenal erosions and in the general population submitted to endoscopic examinations. In conclusion, the analysis of our data presen epidemiological characteristics of duodenal erosions very similar to those pertaining to duodenal ulcer and therefore this pathology has to be included in the wide chapter of the peptic diseases
Anti-Citrullinated Antibodies, Radiological Joint Damages and Their Correlations with Disease Activity Score (DAS28)
Determination of anti-citrullinated peptides (anti-CCP) specificity as a predictor of joint erosive changes, correlation
between their serum level and radiological damages as well as disease activity score (DAS28). A trial has been conducted
on a 211 patient sample fulfilling ACR criteria for rheumatoid arthritis (RA). There was assigned anti-CCP serum level,
disease activity score by the formula for DAS28(3)-CRP and assessed radiological changes degree after Steinbrocker
score. In 132 patient (62,559%) the serum anti-CCP concentration was positive for RA. Specificity of the test was 100%
and sensitivity 65% (Z=0,731, p=0,465). There is a medium intensity correlation between variables representing anti-
-CCP and Steinbrocker score. Pearsonās coefficient was 0,479 and Spearmanās rank correlation coefficient was 0,614, i.e.
statistically significant (p=0,000). There is no statistically significant correlation between variables representing anti-
-CCP and DAS28(3)-CRP. Anti-CCP are good RA predictor and their concentration correlate with radiological damages
degree
Antibody Profile of Pregnant Women with Antiphospholipid Syndrome and Pregnancy Outcome After Treatment with Low Dose Aspirin and Low-Weight-Molecular Heparin
The aim of the research was to show our diagnostic and therapeutic experience with antiphospholipid syndrome
(APS) in pregnant women. 36 pregnant women suspect on APS were included in the study: 32 with primary antiphospholipd
syndrome (PAPS) and 4 with secondary antiphospholipid syndrome (SAPS). All pregnant women received
low-molecular-weight-heparin (LMWH) and low dose aspirin (LDA) therapy. Control group represented 26 women with
SAPS and previous bad reproductive anamnesis. Average pregnancy lasted 37.060.707 weeks. LMWH and LDA therapy
was successful in 97.22%. Lupus anticoagulant (LA) was found to be more frequent in PAPS group (71,87%). Anticardiolipin
antibodies (aCL) were found to be more frequent in SAPS (26,66%). For three patients (3.37%), PAPS was diagnosed
due to a fact that they had positive antibeta2-glycoprotein1 (anti-GP1). To make APS diagnosis, it is of great
importance to search for all antiphospholipid antibodies. LMWH and low dose of acetylsalicylic acid should be the first
choice therapy
Comparison between famotidine (20 mg at bed time) and ranitidine (150 mg at bed time) in the prevention of duodenal ulcer relapse
Famotidin u dozi od 20 mg naveÄer usporeÄivanje s ranitidinom u dozi od 150 mg naveÄer u prevenciji recidiva duodenalnog ulkusa u tijeku 6 mjeseci. Ispitivanjem je obuhvaÄen 71 bolesnik. Bolesnici su bili podijeljeni vi dvije skupine. Prva skupina od 40 bolesnika poslije zaljeÄenja akutnog napada bolesti lijeÄena je ranitidinom vi dozi 150 mg naveÄer, a druga skupina od 31 bolesnika famotidinom od 20 mg naveÄer. Bolesnici iz obje skupine uz ove su lijekove uzimali i antacid. Nakon tri mjeseca u prvoj skupini zabilježen je jedan recidiv a u drugoj skupini nije bilo recidiva. U prvoj skuipini poslije Å”est mjeseci bila svi tri recidiva, a u drugoj bila su dva recidiva dvanaesniÄnog vrijeda. Dva od tri bolesnika u prvoj skupini i oba bolesnika u drugoj skupini s recidivom dvanaesniÄnog vrijeÄa bili su puÅ”aÄi. StatistiÄki znaÄajnih odstupanja vi CKS, koncentraciji ureje, kreatinina i transaminaza vi krvi poslije 3 i 6 mjeseci nije bilo ni u jednoj skupini bolesnika. Nisvi zabilježene ni znaÄajne popratne pojave pri uzimanju oba lijeka.Famotidine given in a 20-mg dose at bed-time was compared to ranitidine administered in a dose of 150 mg at bed-time in the prevention of duodenal ulcer relapse during a six-month period. Seventy-one patients were included in the study. Patients were divided into two groups. Group 1 consisting 40 patients, after curing of acute illness, were treated with ranitidine, 150 mg at bed time, whereas group 2 consisting of 31 patients were treated with famotidine 20 mg at bed-time. Patients from both groups were additionally treated with antacide. After 3 months, one and no cases of relapse were recorded in groups 1 and 2, respectively. After 6 months, three cases of duodenal ulcer relapse were recorded in group 1 and two cases in group 2. Two out of three patients in group 1 and both patients in group 2 with duodenal ulcer relapse were smokers. There were no statistically significant differences between the two groups of patients in RBC, urea concentrations, creatinine and transaminases in blood after 3 and 6 months. No adverse side-effects were observed during the administration of either drug studied
Esomeprazole versus pantoprazole for healing erosive oesophagitis
The aim of this study was to compare the efficacy of esomeprazole and pantoprazole with regard to healing and relief from gastroesophageal reflux disease-related symptoms. I this multicentre, randomized, single-blind study 180 patients (ITT population) diagnosed with endoscopically proven GERD grade A,B,C received esomeprazole (40 mg once daily (o.d.), n = 90) orpantoprazole (40 mg o.d., n = 90). Healing and relief from GERD-related symptoms were assessed at first and final visit (after 4 or 8 weeks of treatment). Esomeprazole 40 mg provided significantly greater healing than pantoprazole 40 mg after 4 weeks of treatment in patients with EE (77.8% vs. 72.2%). Esomeprazole-treated patients were healed after up to 8 weeks of treatment similar those treated with pantoprazole (92.2% vs. 91.1%). The proportion of heartburn-free days was similar in patients treated with esomeprazole and to those treated with pantoprazole