Phases of New Physics in the CMB

Fluctuations in the cosmic neutrino background are known to produce a phase shift in the acoustic peaks of the cosmic microwave background. It is through the sensitivity to this effect that the recent CMB data has provided a robust detection of free-streaming neutrinos. In this paper, we revisit the phase shift of the CMB anisotropy spectrum as a probe of new physics. The phase shift is particularly interesting because its physical origin is strongly constrained by the analytic properties of the Green's function of the gravitational potential. For adiabatic fluctuations, a phase shift requires modes that propagate faster than the speed of fluctuations in the photon-baryon plasma. This possibility is realized by free-streaming relativistic particles, such as neutrinos or other forms of dark radiation. Alternatively, a phase shift can arise from isocurvature fluctuations. We present simple models to illustrate each of these effects. We then provide observational constraints from the Planck temperature and polarization data on additional forms of radiation. We also forecast the capabilities of future CMB Stage IV experiments. Whenever possible, we give analytic interpretations of our results.Comment: 39 pages, 10 figures, 5 tables; v2: minor corrections, references added; v3: corrected Planck parameter constraints, conclusions unchange

Speech Sensorimotor Learning through a Virtual Vocal Tract

Studies of speech sensorimotor learning often manipulate auditory feedback by modifying isolated acoustic parameters such as formant frequency or fundamental frequency using near real-time resynthesis of a participant\u27s speech. An alternative approach is to engage a participant in a total remapping of the sensorimotor working space using a virtual vocal tract. To support this approach for studying speech sensorimotor learning we have developed a system to control an articulatory synthesizer using electromagnetic articulography data. Articulator movement data from the NDI Wave System are streamed to a Maeda articulatory synthesizer. The resulting synthesized speech provides auditory feedback to the participant. This approach allows the experimenter to generate novel articulatory-acoustic mappings. Moreover, the acoustic output of the synthesizer can be perturbed using acoustic resynthesis methods. Since no robust speech-acoustic signal is required from the participant, this system will allow for the study of sensorimotor learning in any individuals, even those with severe speech disorders. In the current work we present preliminary results that demonstrate that typically-functioning participants can use a virtual vocal tract to produce diphthongs within a novel articulatory-acoustic workspace. Once sufficient baseline performance is established, perturbations to auditory feedback (formant shifting) can elicit compensatory and adaptive articulatory responses

Cosmology with Rayleigh scattering of the cosmic microwave background

The cosmic microwave background (CMB) has been a treasure trove for cosmology. Over the next decade, current and planned CMB experiments are expected to exhaust nearly all primary CMB information. To further constrain cosmological models, there is a great benefit to measuring signals beyond the primary modes. Rayleigh scattering of the CMB is one source of additional cosmological information. It is caused by the additional scattering of CMB photons by neutral species formed during recombination and exhibits a strong and unique frequency scaling ($\propto \nu^4$). We will show that with sufficient sensitivity across frequency channels, the Rayleigh scattering signal should not only be detectable but can significantly improve constraining power for cosmological parameters, with limited or no additional modifications to planned experiments. We will provide heuristic explanations for why certain cosmological parameters benefit from measurement of the Rayleigh scattering signal, and confirm these intuitions using the Fisher formalism. In particular, observation of Rayleigh scattering allows significant improvements on measurements of $N_{\rm eff}$ and $\sum m_\nu$.Comment: 20 pages, 10 figure

COVID: decoded - A Website, Blog, and Social Media Page with Resources and Information for the Public

What\u27s the Problem? Information about COVID19 in the news and on social media platforms is overwhelming, confusing, riddled with jargon and sometimes straight up wrong. Makig it easy for the public to misinterpret facts or simply accept headlines and infographics at facevalue without checking with primary and/or reputable sources. The nature of social media also allows for a perpetuation of this misinformation without recourse. Recall the one article floating around Facebook reporting that gargling salt/vinegar water could help prevent COVID19. We needede a source of simplified, reliable information about the pandemic for people outside of the health professions. Medical students are in a unique position to translate the facts into easy to digest information since we have an arm in both the public and health professional worlds

Hundreds of severe pediatric COVID-19 infections in Wuhan prior to the lockdown

Integrative Biolog

Using the COVID-19 to influenza ratio to estimate early pandemic spread in Wuhan, China and Seattle, US

Background: Pandemic SARS-CoV-2 was first reported in Wuhan, China on December 31, 2019. Twenty-one days later, the US identified its first case a man who had traveled from Wuhan to the state of Washington. Recent studies in the Wuhan and Seattle metropolitan areas retrospectively tested samples taken from patients with COVID-like symptoms. In the Wuhan study, there were 4 SARS-CoV-2 positives and 7 influenza positives out of 26 adults outpatients who sought care for influenza-like-illness at two central hospitals prior to January 12, 2020. The Seattle study reported 25 SARS-CoV-2 positives and 442 influenza positives out of 2353 children and adults who reported acute respiratory illness prior to March 9, 2020. Here, we use these findings to extrapolate the early prevalence of symptomatic COVID-19 in Wuhan and Seattle. Methods: For each city, we estimate the ratio of COVID-19 to influenza infections from the retrospective testing data and estimate the age-specific prevalence of influenza from surveillance reports during the same time period. Combining these, we approximate the total number of symptomatic COVID-19 infections. Findings: In Wuhan, there were an estimated 1386 [95% CrI: 420 3793] symptomatic cases over 30 of COVID- 19 between December 30, 2019 and January 12, 2020. In Seattle, we estimate that 2268 [95% CrI: 498, 6069] children under 18 and 4367 [95% CrI: 2776, 6526] adults were symptomatically infected between February 24 and March 9, 2020. We also find that the initial pandemic wave in Wuhan likely originated with a single infected case who developed symptoms sometime between October 26 and December 13, 2019; in Seattle, the seeding likely occurred between December 25, 2019 and January 15, 2020. Interpretation: The spread of COVID-19 in Wuhan and Seattle was far more extensive than initially reported. The virus likely spread for months in Wuhan before the lockdown. Given that COVID-19 appears to be overwhelmingly mild in children, our high estimate for symptomatic pediatric cases in Seattle suggests that there may have been thousands more mild cases at the time.We acknowledge support from NIH grant U01 GM087791 and Tito’s Handmade VodkaIntegrative Biolog

Serial Interval of COVID-19 among Publicly Reported Confirmed Cases.

We estimate the distribution of serial intervals for 468 confirmed cases of coronavirus disease reported in China as of February 8, 2020. The mean interval was 3.96 days (95% CI 3.53-4.39 days), SD 4.75 days (95% CI 4.46-5.07 days); 12.6% of case reports indicated presymptomatic transmission

Estimating the Impact of foregrounds on the Future Detection of Rayleigh scattering

Rayleigh scattering of the cosmic microwave background (CMB) by neutral hydrogen shortly after recombination leaves frequency-dependent imprints on intensity and polarization fluctuations. High signal-to-noise observations of CMB Rayleigh scattering would provide additional insight into the physics of recombination, including greater constraining power for parameters like the primordial helium fraction, the light relic density, and the sum of neutrino masses. However, such a measurement of CMB Rayleigh scattering is challenging due to the presence of astrophysical foregrounds, which are more intense at the high frequencies, where the effects of Rayleigh scattering are most prominent. Here we forecast the detectability of CMB Rayleigh scattering including foreground removal using blind internal linear combination methods for a set of near-future surveys. We show that atmospheric effects for ground-based observatories and astrophysical foregrounds pose a significant hindrance to detecting CMB Rayleigh scattering with experiments planned for this decade, though a high-significance measurement should be possible with a future CMB satellite.Comment: 14 pages, 12 figure

Treatment utilization and outcomes in elderly patients with locally advanced esophageal carcinoma: A review of the National Cancer Database

For elderly patients with locally advanced esophageal cancer, therapeutic approaches and outcomes in a modern cohort are not well characterized. Patients ≥70 years old with clinical stage II and III esophageal cancer diagnosed between 1998 and 2012 were identified from the National Cancer Database and stratified based on treatment type. Variables associated with treatment utilization were evaluated using logistic regression and survival evaluated using Cox proportional hazards analysis. Propensity matching (1:1) was performed to help account for selection bias. A total of 21,593 patients were identified. Median and maximum ages were 77 and 90, respectively. Treatment included palliative therapy (24.3%), chemoradiation (37.1%), trimodality therapy (10.0%), esophagectomy alone (5.6%), or no therapy (12.9%). Age ≥80 (OR 0.73), female gender (OR 0.81), Charlson-Deyo comorbidity score ≥2 (OR 0.82), and high-volume centers (OR 0.83) were associated with a decreased likelihood of palliative therapy versus no treatment. Age ≥80 (OR 0.79) and Clinical Stage III (OR 0.33) were associated with a decreased likelihood, while adenocarcinoma histology (OR 1.33) and nonacademic cancer centers (OR 3.9), an increased likelihood of esophagectomy alone compared to definitive chemoradiation. Age ≥80 (OR 0.15), female gender (OR 0.80), and non-Caucasian race (OR 0.63) were associated with a decreased likelihood, while adenocarcinoma histology (OR 2.10) and high-volume centers (OR 2.34), an increased likelihood of trimodality therapy compared to definitive chemoradiation. Each treatment type demonstrated improved survival compared to no therapy: palliative treatment (HR 0.49) to trimodality therapy (HR 0.25) with significance between all groups. Any therapy, including palliative care, was associated with improved survival; however, subsets of elderly patients with locally advanced esophageal cancer are less likely to receive aggressive therapy. Care should be taken to not unnecessarily deprive these individuals of treatment that may improve survival