Serum-prostatic specific antigen level as a promising marker in infertile women with polycystic ovarian disease

Objective: To evaluate value of serum prostatic specific antigen (PSA) as a marker for PCOS infertile women undergoing ovulation induction. Design: A prospective clinical trial Setting: Department of obstetric and gynecology, Suez Canal university. Materials and Methods: Eighty four women (64 with PCOS, 20 normoovulatory as control) were evaluated clinically and by pelvic ultrasound. Serum FSH, LH and Testosterone were estimated at 2nd day of menses while E2 and Progesterone were estimated at the midluteal phase using highly sensitive ELFA technique ,TPSA was estimated at both 2nd day of menses and at the midluteal phase using the Immulite / Immulite 1000 system. Results: The study group exhibited significant higher mean TPSA 2nd day (0.040 ng/dl) versus (0.003 ng/dl, P=0.031) in normal control group, and also significant higher mean TPSA midluteal (0.020 ng/dl) versus (0.002 ng/dl, P=0.022) as compared to control group. Subgroup analysis according to response showed that responders exhibited significant reduction in TPSA level midluteal (0.008 ng/dl) than that on 2nd day (0.011 ng/dl, P<0.001). Conclusion: the mean serum TPSA could be detected in high significant concentrations in the serum of PCOD infertile women with significant decreasing concentrations after induction of ovulation, thus TPSA can be used as a promising marker for ovarian response in infertile women due to PCOD