Carcinogenesis Vol.21 No.8 Pp.1485--1490, 2000

s previously been shown to cause various forms forms of leukemia as well as in benzene-induced leukemia (4). of genetic damage, including aneusomy and the loss and Aneusomy, the loss or gain of specific chromosomes, is gain of chromosomes. However, the target cells for leukem- common in MDS and leukemia. Monosomy 7 is the most ogenesis are the pluripotent stem cells or early progenitor common early event in therapy-related MDS and AML (11,12) cells which carry the CD34 antigen (CD34 cells). In this and predisposes infants to juvenile AML (13,14). Trisomy 8 study, human cord blood, which is particularly rich in is also a common change detected in AML and has been cells, was exposed to hydroquinone for 72 h in a associated with smoking-induced leukemia (15), which is medium that favored CD34 cell survival and growth. thought to be due, in part, to the benzene content of cigarette cells were then isolated. Fluorescence smoke. Increased levels of monosomy 7 an