56 research outputs found
From menarche to regular menstruation - Endocrinological background
Marked changes in hormone secretion occur from childhood to adulthood. Prior to puberty gonadotropin-releasing hormone (GnRH) secretion is markedly suppressed. At the onset of puberty, the hypothalamic gonadostat is derepressed and the amplitude of GnRH pulses increases. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels increase gradually during puberty stimulating follicle maturation and estrogen production in the ovaries. Only the negative feedback mechanism is powerful before puberty, while the positive feedback mechanism becomes active for the first time in late puberty. As a result, normal cyclicity is usually established at that time. During normal menstrual cycle, steroidal and nonsteroidal hormones mediate the effect of the ovaries on the hypothalamic-pituitary system. Estradiol and progesterone are important regulators of FSH and LH secretion, while inhibins play a role in the control of FSH secretion. Gonadotropin surge attenuating factor (GnSAF) is a nonsteroidal ovarian substance that controls the amplitude of the midcycle LH surge by antagonizing the sensitizing effect of estradiol on the pituitary
Follicle stimulating hormone stimulates the production of gonadotrophin surge attenuating factor (GnSAF) in vivo
The endocrine effects of multiple folliculogenesis in women
SIGLEAvailable from British Library Document Supply Centre- DSC:DX79695 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Changes in pituitary response to GnRH during the luteal-follicular transition of the human menstrual cycle
SUPEROVULATION INDUCTION IN WOMEN SUPPRESSES LUTEINIZING HORMONE SECRETION AT THE PITUITARY LEVEL
Attenuation of gonadotrophin release and reserve in superovulated women by gonadotrophin surge attenuating factor (GnSAF)
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