EFFICACY AND SAFETY OF THERAPY WITH ATORVASTATIN IN HIGH DOSES

Large epidemiological trails shown that hypercholesterolemia is one of the main risk factor of ischemic heart disease (IHD). Correction of the hypercholesterolemia with GmGKoA reductase inhibitors (statins) essentially reduces IHD morbidity and mortality. The lower serum level of low density lipoprotein is - the lower risk of cardiovascular diseases and their complications are. Efficacy and safety of atorvastatin therapy in high doses is discussed in patients with IHD and dyslipidemia. Atorvastatin in high doses is more effective than standard therapy for prevention of cardiovascular complications. Atorvastatin is also effective in patients with recurrent cardiovascular events. Atorvastatin in high doses is safe and well tolerated. Serious side effects due to atorvastatin use (myopathy and rhabdomyolysis) are very rare. Generic atorvastatin 80 mg OD in ATLANTIC study was effective and safe. However efficacy and safety of other atorvastatin generics in dose of 80 mg OD is not well studied and it is necessary further studies

Production of para-- and orthopositronium at relativistic heavy ion colliders

We consider the ortho-- and parapositronium production in the process $AA \to AA+$ Ps where A is a nucleus with the charge number Z. The inclusive cross section and the energy distribution of the relativistic Ps are calculated which are of primary interest from the experimental point of view. The accuracy of the corresponding cross sections is given by omitting terms $\sim (Z\alpha )^2/L^2$ for the para--Ps and $\sim (Z\alpha)^2/L$ for the ortho--Ps production where $L=\ln{\gamma^2} \approx 9$ and 16 for the RHIC and the LHC. Within this accuracy the multiphoton (Coulomb) corrections are taken into account. We show that the RHIC and the LHC will be Ps factories with a productions rate of about $10^5 \div 10^8$ relativistic Ps per day. The fraction of the ortho--Ps is expected to be of the same order as that of the para--Ps for Au--Au and Pb--Pb collisions.Comment: 22 pages, 5 figures, RevTeX, misprint correcte

Production of relativistic positronium in collisions of photons and electrons with nuclei and atoms

We consider the production of ultrarelativistic positronium (Ps) in $\gamma A \to Ps + A$ and $e A \to Ps + e A$ processes where $A$ is an atom or a nucleus with charge $Ze$. For the photoproduction of para- and ortho-Ps and the electroproduction of para-Ps we obtain the most complete description compared with previous works. It includes high order $Z \alpha$ corrections and polarization effects. The accuracy of the obtained cross sections is determined by omitted terms of the order of the inverse Ps Lorentz factor squared. The studied high order multi-photon electroproduction of ortho-Ps dominates for the collision of electrons with heavy atoms over the bremsstrahlung production from the electron via a virtual photon proposed by Holvik and Olsen. Our results complete and correct the studies of those authors.Comment: 19 pages, 9 figures, RevTex; v2: minor corrections for the accuracy of the results, a discussion of the literature added in a footnote, one additional reference; v3: diagram of Fig.2 correcte

A number-conserving linear response study of low-velocity ion stopping in a collisional magnetized classical plasma

The results of a theoretical investigation on the low-velocity stopping power of the ions moving in a magnetized collisional plasma are presented. The stopping power for an ion is calculated employing linear response theory using the dielectric function approach. The collisions, which leads to a damping of the excitations in the plasma, is taken into account through a number-conserving relaxation time approximation in the linear response function. In order to highlight the effects of collisions and magnetic field we present a comparison of our analytical and numerical results obtained for a nonzero damping or magnetic field with those for a vanishing damping or magnetic field. It is shown that the collisions remove the anomalous friction obtained previously [Nersisyan et al., Phys. Rev. E 61, 7022 (2000)] for the collisionless magnetized plasmas at low ion velocities. One of major objectives of this study is to compare and contrast our theoretical results with those obtained through a novel diffusion formulation based on Dufty-Berkovsky relation evaluated in magnetized one-component plasma models framed on target ions and electrons.Comment: Submitted to Phys. Rev. E, 17 pages, 4 figure

Rayleigh-Taylor instability of crystallization waves at the superfluid-solid 4He interface

At the superfluid-solid 4He interface there exist crystallization waves having much in common with gravitational-capillary waves at the interface between two normal fluids. The Rayleigh-Taylor instability is an instability of the interface which can be realized when the lighter fluid is propelling the heavier one. We investigate here the analogues of the Rayleigh-Taylor instability for the superfluid-solid 4He interface. In the case of a uniformly accelerated interface the instability occurs only for a growing solid phase when the magnitude of the acceleration exceeds some critical value independent of the surface stiffness. For the Richtmyer-Meshkov limiting case of an impulsively accelerated interface, the onset of instability does not depend on the sign of the interface acceleration. In both cases the effect of crystallization wave damping is to reduce the perturbation growth-rate of the Taylor unstable interface.Comment: 8 pages, 2 figures, RevTe

Binary collisions of charged particles in a magnetic field

Binary collisions between charged particles in an external magnetic field are considered in second-order perturbation theory, starting from the unperturbed helical motion of the particles. The calculations are done with the help of an improved binary collisions treatment which is valid for any strength of the magnetic field, where the second-order energy and velocity transfers are represented in Fourier space for arbitrary interaction potentials. The energy transfer is explicitly calculated for a regularized and screened potential which is both of finite range and non-singular at the origin, and which involves as limiting cases the Debye (i.e., screened) and Coulomb potential. Two distinct cases are considered in detail. (i) The collision of two identical (e.g., electron-electron) particles; (ii) and the collision between a magnetized electron and an uniformly moving heavy ion. The energy transfer involves all harmonics of the electron cyclotron motion. The validity of the perturbation treatment is evaluated by comparing with classical trajectory Monte--Carlo calculations which also allows to investigate the strong collisions with large energy and velocity transfer at low velocities. For large initial velocities on the other hand, only small velocity transfers occur. There the non-perturbative numerical classical trajectory Monte--Carlo results agree excellently with the predictions of the perturbative treatment.Comment: submitted to Phys. Rev.