DEGUM, ÖGUM, SGUM and FMF Germany Recommendations for the Implementation of First-Trimester Screening, Detailed Ultrasound, Cell-Free DNA Screening and Diagnostic Procedures

First-trimester screening between 11 + 0 and 13 + 6 weeks with qualified prenatal counseling, detailed ultrasound, biochemical markers and maternal factors has become the basis for decisions about further examinations. It detects numerous structural and genetic anomalies. The inclusion of uterine artery Doppler and PlGF screens for preeclampsia and fetal growth restriction. Low-dose aspirin significantly reduces the prevalence of severe preterm eclampsia. Cut-off values define groups of high, intermediate and low probability. Prenatal counseling uses detection and false-positive rates to work out the individual need profile and the corresponding decision: no further diagnosis/screening - cell-free DNA screening - diagnostic procedure and genetic analysis. In pre-test counseling it must be recognized that the prevalence of trisomy 21, 18 or 13 is low in younger women, as in submicroscopic anomalies in every maternal age. Even with high specificities, the positive predictive values of screening tests for rare anomalies are low. In the general population trisomies and sex chromosome aneuploidies account for approximately 70 % of anomalies recognizable by conventional genetic analysis. Screen positive results of cfDNA tests have to be proven by diagnostic procedure and genetic diagnosis. In cases of inconclusive results a higher rate of genetic anomalies is detected. Procedure-related fetal loss rates after chorionic biopsy and amniocentesis performed by experts are lower than 1 to 2 in 1000. Counseling should include the possible detection of submicroscopic anomalies by comparative genomic hybridization (array-CGH). At present, existing studies about screening for microdeletions and duplications do not provide reliable data to calculate sensitivities, false-positive rates and positive predictive values

Historiam Vitae Et Controversiarum Victorini Strigelii Kauffbeurensis / ... Praeside ... Christiano Eberhardo Weismanno, ... publico eruditorum examini submittit Avthor Et Respondens Hieronymus Merz, Kauffbeurensis. Ad diem [...] mensis Octobris A.D. MDCCXXXII

HISTORIAM VITAE ET CONTROVERSIARUM VICTORINI STRIGELII KAUFFBEURENSIS / ... PRAESIDE ... CHRISTIANO EBERHARDO WEISMANNO, ... PUBLICO ERUDITORUM EXAMINI SUBMITTIT AVTHOR ET RESPONDENS HIERONYMUS MERZ, KAUFFBEURENSIS. AD DIEM [...] MENSIS OCTOBRIS A.D. MDCCXXXII Historiam Vitae Et Controversiarum Victorini Strigelii Kauffbeurensis / ... Praeside ... Christiano Eberhardo Weismanno, ... publico eruditorum examini submittit Avthor Et Respondens Hieronymus Merz, Kauffbeurensis. Ad diem [...] mensis Octobris A.D. MDCCXXXII (1) Einband (1) Titelblatt (4) Widmung (6) Synopsis. (10) Text (12

Социальная работа с детьми в МАДОУ №86 города Томска

Реферат Тема ВКР: Социальная работа с детьми в МАДОУ №86 г. Томска. Объем ВКР: 80, таблиц 1, рисунков 10, количество источников литературы 61, приложений 2. Объектом исследования: дети дошкольного возраста и их социальные проблемы. Предмет исследования: профессиональная деятельность специалистов по социальной работе с детьми в МАДОУ №86 г. Томска. Целью исследования: оценка эффективности социальной работы с детьми в МАДОУ №86 г. Томска. Задачи исследования: 1. Описать теоретические аспекты социальной работы в дошкольном образовательном учреждение; 2. Исследовать специфику социальной работы с детьми в МАДОУ №86 г. Томска; 3. Провести анализ эффективности социальной работы с детьми в МАДОУ №86 г. Томска. 4. Разработать рекомендации по улучшению социальной работы с детьми в МАДОУ №86 г. Тоabstract WRC Subject : Social work with children in Mado №86 Tomsk . WRC Volume : 80 , Table 1, Figure 10 , the number of literary sources 61 Annex 2. The object of the study : children of preschool age and their social problems . Subject of research : professional activity of social work with children in Mado №86 Tomsk . The aim of the study : evaluation of the effectiveness of social work with children in Mado №86 Tomsk . Research objectives : 1. Describe the theoretical aspects of social work in preschool educational institution; 2. To investigate the specificity of social work with children in Mado №86 Tomsk ; 3. To analyze the effectiveness of social work with children in Mado №86 Tomsk . 4. To develop recommendations for improvement of social work with children in Mado №86 Tomsk

Prenatal ultrasound diagnosis of Tessier number 7 cleft: Case report and review of the literature

Lateral or transverse facial clefts are the most frequent of the atypical facial clefts, classified by Tessier as no. 7 clefts. Most of the cases are diagnosed at birth, while few cases are diagnosed prenatally. We report a case of prenatal ultrasound detection and three-dimensional characterisation of a lateral facial cleft at 21 weeks of gestation, which was terminated at 22 weeks. It was a transverse cleft, running through the left cheek towards the ear, along with micrognathia and mild polyhydramnios. We also present a review on classification, anatomical features and prenatal diagnosis of Tessier no. 7 cleft