Support for students with SMA during the transition from primary to secondary school

Katedra speciální pedagogikyFaculty of EducationPedagogická fakult

Jak na Moderní revue

17317

Aktivity OCT a glykační poškození v mitochondriích jater krysy

AKTIVITA OCT A GLYKAČNÍ POŠKOZENÍ V MITOCHONDRIÍCH JATER KRYSY Lucie Merhutová Diplomová práce. Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové. 2007 Tato práce byla vytvořena na základě pokusů provedených v LBBCV (Laboratoři buněčné biologie a biochemie stárnutí) v rámci Univerzity Paris Diderot - Paris 7. Tým této laboratoře studuje mechanismy posttranslačních neenzymatických modifikací proteinů, zahrnutých v patofyziologii stárnutí. Glykace je jedním z mechanismů odpovědných za modifikaci nitrobuněčných makromolekul, které vedou ke ztrátě jejich struktury a funkce. Ornitin karbamoyltransferáza (OCT), druhý enzym močovinového cyklu, byl v předchozím výzkumu identifikován jako jeden z enzymů, které jsou významně glykovány uvnitř mitochondrií jater stárnoucích krys. Cílem této práce bylo sledovat glykaci OCT in vitro a ex vivo a její vliv na funkci tohoto enzymu. Vzorky purifikované OCT a extraktů mitochondriální matrix byly inkubovány s methylglyoxalem, jedním z nejreaktivnějších fyziologických glykačních činidel. U vzorků byla změřena enzymatická aktivita a byly podrobeny imunochemické analýze. Podařilo se nám prokázat, že methylglyoxal modifikuje OCT jak in vitro, tak ex vivo, a způsobuje velice rychlý a rozsáhlý pokles jeho enzymatické aktivity. Podle výsledků této studie vznikají...OCT ACTIVITY AND GLYCATION DAMAGE IN RAT LIVER MITOCHONDRIA Lucie Merhutová Diploma thesis. Charles University in Prague, Faculty of Pharmacy in Hradec Králové. 2007 This work was created following investigations carried out in LBBCV (Laboratoire de Biologie et Biochimie Cellulaire du Vieillissement) at University Paris Diderot - Paris 7. The team of this laboratory studies the mechanisms of posttranslational non-enzymatic modifications of proteins, involved in the pathophysiology of aging. Glycation is one of the mechanisms responsible for the modification of intracellular macromolecules leading to the loss of their structure and function. In previous investigations, ornithine carbamoyltransferase (OCT), the second enzyme of urea cycle, has been identified as one of the markedly glycated proteins in liver mitochondria of senescent rats. The goal of this work was to investigate in vitro and ex vivo glycation of OCT and the effect of glycation on its function. Purified OCT and mitochondrial matrix extracts were incubated with methylglyoxal, one of the most reactive physiological glycating agents, and submitted to the enzymatic assay and immunochemical analysis. We demonstrated that methylglyoxal modifies OCT both in vitro and ex vivo and causes rapid and extensive decrease in its enzymatic activity....Katedra biochemických vědDepartment of Biochemical SciencesFaculty of Pharmacy in Hradec KrálovéFarmaceutická fakulta v Hradci Králov

Překladatelé a překladatelky v dějinách literatury: aktuální akcenty

13113

Creative techniques in supervision

The main aim of my diploma work called "Creative Techniques in Supervision", which is divided into two parts, is creating of a practical manual containing art-therapeutic techniques that can be used in supervision. This work is dedicated to all supervisors who are originally not art-therapist but despite this fact want use this way of work. The first part of my work is an introduction of the art-therapeutic method that (with the use of technical literature) deals with definitions of special terms. This part is dedicated to the theoretical knowledge and is also filled up with my own knowledge and experience from the field of the art-therapeutic praxes. It is actually a foundation for the second part of my diploma work that contains concrete techniques that can be used in supervision. The second part of my work contains a list of twenty creative techniques - methods of work - that are suitable for the individual, group or team supervision. All the techniques are proceeded according to one schema. It means that in all techniques are mentioned theirs goals, forms, technical severity, supposed time, procedure and also possibly risks. Each technique dispose of needed helpful realisation tools. Enclosure of my diploma work contains several casuistic including photo-documentation

Le bateau ivre in Czech translation

This thesis is focused on the Drunken Boat poem by J. A. Rimbaud and its Czech translation. In particular, it focuses on the content of the poem and the meaning of specific images. It seeks an answer to a question to what extent does the preservation of poem's formal elements adversely affect its content and the vividness of its images. For this purpose, an original Czech translation of the poem is introduced, which is in turn analysed together with the other pre- existing translations. The study finds a parallel between Rimbaud's own path to freedom, leading from formal aspects to content, and his work, reflecting the same principles. For this reason, the formal aspects of the original poem and its Czech translations (e.g. Čapek, Hrubín, Neznal, Kadlec) do not represent the primary topic of this work. Instead, the study focuses on preserving the content of the poem and its new interpretations. Finally, the thesis also provides a review of the Czech translations of the poem

Simulation teaching of telephonic instruction of first aid provision

Bakalářská práce se zabývá simulační výukou a jejím využitím ve vzdělávání nelékařských zdravotnických pracovníků, konkrétně zdravotnických záchranářů. Simulační výuka je nedílnou součástí přípravy studentů na jejich budoucí povolání, jelikož mohou detekovat vlastní problematické oblasti, kterým se v praxi lze vyvarovat. V teoretické části je popsána historie simulační výuky, její moderní pojetí a fáze. Dále jsou přiblíženy aspekty poskytování telefonicky asistované první pomoci a telefonicky asistované neodkladné resuscitace. Výzkumná část se zabývá vytvořením scénáře simulace a jeho ověřením v praxi. Simulovaná situace se týká telefonicky asistované první pomoci při aspiraci a následné telefonicky asistované neodkladné resuscitace.This bachleor thesis deals with simulation teaching and its use in the education of non-medical health professionals, especially paramedics. Simulation teaching is an integral part of preparing students for their future careers, as they can detect their own problém areas, which can be avoided in practice. The teoretical part describes the history of simulation teaching, its modern concept and phases. Aspects of the provision of thelephone-assisted first aid and telephone assisted emergency resuscitation are also described. The research part deals with the creation of simulation scenario and its verification in practice. The simulated situation concerns telephone-assisted first aid for aspiration and subsequent telephone-assisted emergency resuscitation

The space in Horacio Quiroga's short stories

( in English) The aim of this Bachelor's thesis is to describe the category of space in Horacio Quiroga's short novel. Above all, it focuses on the creation of so-called jungle tales and its particular environment. The first part is theoretical and tries to sum up the most important facts of the author's life and creation and it is followed by the part summarizing various information about the theory of the concept of space in literature. A special chapter is dedicated to (the) a term "topos", which is appllied to the hispanoamerican literature and to the generation of regionalism, especially to the novel of the jungle. The work continues with the a practical analysis of the short stories. It describes the comparison of expressions of Quiroga's different styles and the image of the province of Misiones, where the author lived for a long time and which remains captured in his works. Furthermore, the thesis focuses on the influence of the environment of the jungle on the characters and what kind of characters it creates. It finishes with the image of the jungle as a sacred place

Česká literární moderna v časopise Aus fremden Zungen — čtyři příklady prostředkování // Czech literary modernism in the journal Aus fremden Zungen — four examples of mediation

The study focuses on Bronislav Wellek, Adolph Donath, Camill Hoffmann, Oskar Wiener and Otto Hauser and their translations and articles on modern Czech literature published in the German journal Aus fremden Zungen (1891–1910). This fortnightly established by Joseph Kürschner dealt exclusively with foreign literature. Its openness to all kinds of literary currents and little-known minor literatures was unique within the system of German literary journals. A comparison indicates the key role played by mediators. The primary requirement for their activity was multilingualism, and it turns out that in the case of all the figures under consideration, language did not necessarily have the nationally symbolic significance ascribed by politics, and their identity basically did not depend on their use of one language or another. The progress and success of this mediation was not just decided by the literary standard of the translation, but all five translators were concerned to improve the standard of translation, as well as to change the approach to translation in general. The choice of text and its succeeded publication was determined by the involvement of the mediators in the Czech and German literary context. Hence Bronislav Wellek focused primarily on translations and interpretations of poetry by Jaroslav Vrchlický and J. S. Machar, whom he knew personally and who also introduced him to their own literary and intellectual circles. It was thanks to Vrchlický that he printed his translations in Eduard Albert’s anthologies Poesie aus Böhmen (1893–1895). Machar was responsible for other translations, e.g. Hilbert’s drama Vina, which Hermann Bahr was to help promote in the German-language sphere. Between 1896 and 1898, Adolph Donath attempted to build up his position as mediator between the Moderní revue circle and some representatives of Viennese modernism (e.g. Karl Kraus, Peter Altenberg and Felix Rappaport). For Aus fremden Zungen he translated an impressionistic short story by Luisa Ziková Bílý květ (White Flower). In a fivepart series and an accompanying study modern Czech prose (J. Zeyer, V. Mrštík, F. X. Svoboda, J. K. Šlejhar and R. Svobodová) was presented by Camill Hoffmann and Oskar Wiener. Their mediation activities were based on direct relations with Prague Czech authors of the youngest generation, on whom Hoffmann also focused in his articles for other German journals, though in Aus fremden Zungen he was concerned with surveying the modernist work of the 1890s. Samples of Czech prose were followed on by translations from modern Czech lyric poetry (O. Březina, A. Sova, K. Hlaváček and V. Dyk) written by Otto Hauser. This polyglot and translator from numerous languages was a different kind of Viennese mediator. In contrast to Wellek and Hoffmann, Hauser was only in sporadic correspondence with Sova and Březina. His literary assessment of their poetry was based on his broad knowledge of contemporary European poetry, including minor literatures (such as Danish, Dutch and Croatian) and as such is of importance. These examples show that literary mediation is a complex rapprochement of variously defined and construed contexts, which have their reflected and unrealized limits