Dense stellar clump formation driven by strong quasar winds in the FIRE cosmological hydrodynamic simulations

We investigate the formation of dense stellar clumps in a suite of high-resolution cosmological zoom-in simulations of a massive, star forming galaxy at $z \sim 2$ under the presence of strong quasar winds. Our simulations include multi-phase ISM physics from the Feedback In Realistic Environments (FIRE) project and a novel implementation of hyper-refined accretion disk winds. We show that powerful quasar winds can have a global negative impact on galaxy growth while in the strongest cases triggering the formation of an off-center clump with stellar mass ${\rm M}_{\star}\sim 10^{7}\,{\rm M}_{\odot}$, effective radius ${\rm R}_{\rm 1/2\,\rm Clump}\sim 20\,{\rm pc}$, and surface density $\Sigma_{\star} \sim 10^{4}\,{\rm M}_{\odot}\,{\rm pc}^{-2}$. The clump progenitor gas cloud is originally not star-forming, but strong ram pressure gradients driven by the quasar winds (orders of magnitude stronger than experienced in the absence of winds) lead to rapid compression and subsequent conversion of gas into stars at densities much higher than the average density of star-forming gas. The AGN-triggered star-forming clump reaches ${\rm SFR} \sim 50\,{\rm M}_{\odot}\,{\rm yr}^{-1}$ and $\Sigma_{\rm SFR} \sim 10^{4}\,{\rm M}_{\odot}\,{\rm yr}^{-1}\,{\rm kpc}^{-2}$, converting most of the progenitor gas cloud into stars in $\sim$2\,Myr, significantly faster than its initial free-fall time and with stellar feedback unable to stop star formation. In contrast, the same gas cloud in the absence of quasar winds forms stars over a much longer period of time ($\sim$35\,Myr), at lower densities, and losing spatial coherency. The presence of young, ultra-dense, gravitationally bound stellar clumps in recently quenched galaxies could thus indicate local positive feedback acting alongside the strong negative impact of powerful quasar winds, providing a plausible formation scenario for globular clusters.Comment: 14 pages, 12 figure

Dense stellar clump formation driven by strong quasar winds in the FIRE cosmological hydrodynamic simulations

We investigate the formation of dense stellar clumps in a suite of high-resolution cosmological zoom-in simulations of a massive, star-forming galaxy at z ∼ 2 under the presence of strong quasar winds. Our simulations include multiphase ISM physics from the Feedback In Realistic Environments (FIRE) project and a no v el implementation of hyper-refined accretion disc winds. We show that powerful quasar winds can have a global negative impact on galaxy growth while in the strongest cases triggering the formation of an off-centre clump with stellar mass M ∼ 10 7 M , effective radius R 1 / 2 Clump ∼ 20 pc , and surface density ∼10 4 M pc −2 . The clump progenitor gas cloud is originally not star -forming, b ut strong ram pressure gradients driven by the quasar winds (orders of magnitude stronger than experienced in the absence of winds) lead to rapid compression and subsequent conversion of gas into stars at densities much higher than the average density of star-forming gas. The AGN-triggered star-forming clump reaches SFR ∼ 50 M yr −1 and SFR ∼ 10 4 M yr −1 kpc −2 , converting most of the progenitor gas cloud into stars in ∼2 Myr, significantly faster than its initial free-fall time and with stellar feedback unable to stop star formation. In contrast, the same gas cloud in the absence of quasar winds forms stars over a much longer period of time ( ∼35 Myr), at lower densities, and losing spatial coherency. The presence of young, ultra-dense, gravitationally bound stellar clumps in recently quenched galaxies could thus indicate local positive feedback acting alongside the strong negative impact of powerful quasar winds, providing a plausible formation scenario for globular clusters

Local positive feedback in the overall negative: the impact of quasar winds on star formation in the FIRE cosmological simulations

Negative feedback from accreting supermassive black holes is regarded as a key ingredient in suppressing star formation and quenching massive galaxies. However, several models and observations suggest that black hole feedback may have a positive effect, triggering star formation by compressing interstellar medium gas to higher densities. We investigate the dual role of black hole feedback using cosmological hydrodynamic simulations from the Feedback In Realistic Environments (FIRE) project, including a novel implementation of hyper-refined accretion-disc winds. Focusing on a massive, star-forming galaxy at $z \sim 2$ ($M_{\rm halo} \sim 10^{12.5} \, {\rm M}_{\odot}$), we show that strong quasar winds with kinetic power $\sim$10$^{46}$ erg/s acting for $>$20$\,$Myr drive the formation of a central gas cavity and can dramatically reduce the star formation rate surface density across the galaxy disc. The suppression of star formation is primarily driven by reducing the amount of gas that can become star-forming, compared to directly evacuating the pre-existing star-forming gas reservoir (preventive feedback dominates over ejective feedback). Despite the global negative impact of quasar winds, we identify several plausible signatures of local positive feedback, including: (1) spatial anti-correlation of wind-dominated regions and star-forming clumps, (2) higher local star formation efficiency in compressed gas near the edge of the cavity, and (3) increased local contribution of outflowing material to star formation. Stars forming under the presence of quasar winds tend to do so at larger radial distances. Our results suggest that positive and negative AGN feedback can coexist in galaxies, but local positive triggering of star formation plays a minor role in global galaxy growth.Comment: 17 pages, 12 figure

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701