5 research outputs found
Chiral ferrocene-based P,S ligands for Ir-catalyzed hydrogenation of minimally functionalized olefins. Scope and limitations
International audienceA family of 12 modular ferrocenyl planar chiral phosphine-thioethers (P,S) has been studied in the asymmetric hydrogenation of minimally functionalized alkenes. These ligands differ by the substituent on sulfur or by the linker between the ferrocene moiety and the sulfur atom (no linker, methylene or methyl substituted methylene linker bearing an additional element of chirality). The cationic iridium(cod) complexes of the different P,S ligands have been efficiently synthesized. For the majority of the ligands, coordination yielded only a single diastereoisomer with full control of the absolute configuration on sulfur. The different iridium complexes have been used in the hydrogenation of various di, tri, and tetrasubstituted minimally functionalized olefins. Conversions and enantioselectivities are highly dependent on the ligand and substrate structure. Full conversions and low-to-excellent enantioselectivities could be obtained (maximum ee from 14 to 94% for 1,1-disubsituted alkenes, from 17 to 99% for trisubstituted olefins, and 34% for the tetrasubstituted alkene)
A nomogram for predicting serious complications in patients with solid tumors and apparently stable febrile neutropenia: Prospective data on 781 consecutive episodes from the FINITE study.
A nomogram for predicting complications in patients with solid tumours and seemingly stable febrile neutropenia
Background: We sought to develop and externally validate a nomogram and web-based calculator to individually predict
the development of serious complications in seemingly stable adult patients with solid tumours and episodes of febrile
neutropenia (FN).
Patients and methods: The data from the FINITE study (n ÂĽ 1133) and University of Salamanca Hospital (USH) FN registry (n ÂĽ 296)
were used to develop and validate this tool. The main eligibility criterion was the presence of apparent clinical stability, defined as
events without acute organ dysfunction, abnormal vital signs, or major infections. Discriminatory ability was measured as the
concordance index and stratification into risk groups.
Results: The rate of infection-related complications in the FINITE and USH series was 13.4% and 18.6%, respectively. The
nomogram used the following covariates: Eastern Cooperative Group (ECOG) Performance Status X2, chronic obstructive
pulmonary disease, chronic cardiovascular disease, mucositis of grade X2 (National Cancer Institute Common Toxicity Criteria),
monocytes o200/mm3
, and stress-induced hyperglycaemia. The nomogram predictions appeared to be well calibrated in both
data sets (Hosmer–Lemeshow test, P40.1). The concordance index was 0.855 and 0.831 in each series. Risk group stratification
revealed a significant distinction in the proportion of complications. With a X116-point cutoff, the nomogram yielded the
following prognostic indices in the USH registry validation series: 66% sensitivity, 83% specificity, 3.88 positive likelihood ratio, 48%
positive predictive value, and 91% negative predictive value.
Conclusions: We have developed and externally validated a nomogram and web calculator to predict serious complications that
can potentially impact decision-making in patients with seemingly stable FN