The Orbital Period of the Optical/X-Ray Burster X1735-444 (V926 Sco)

We present extensive CCD photometry of the optical counterpart of X1735–444 which reveals the orbital period of the system. It is periodically variable with a period of 4.654 hr and a full amplitude of 0.15 mag. The mean modulation is quasi-sinusoidal; there are, however, also significant intrinsic deviations from the mean light curve

Supervising Mental Health Clinicians in The Context of Complex Organisational Dynamics

This article discusses the complex dynamics and challenges of providing supervision to mental health clinicians working within an organisational context when the supervisor is not part of the organisation and has no formal managerial or accountability responsibility. It considers two models of supervision and their application to three supervisory relationships in an organisational context. It concludes that for supervision to be effective there needs to be a consideration of the social defences in operation within the organisation and how they are met by the anxieties and defences of the supervisor and supervisee. This requires a mixed approach by the supervisor of the technical with the inter-subjective as a reliance on one model of supervision risks limiting the effectiveness of the intervention. The role of the supervisor can enable the supervisee to establish a clinical framework and the necessary environment essentials for their practice

Base damage, local sequence context andTP53mutation hotspots: a molecular dynamics study of benzo[a]pyrene induced DNA distortion and mutability

The mutational pattern for the TP53 tumour suppressor gene in lung tumours differs to other cancer types by having a higher frequency of G:C>T:A transversions. The aetiology of this differing mutation pattern is still unknown. Benzo[a]pyrene,diol epoxide (BPDE) is a potent cigarette smoke carcinogen that forms guanine adducts at TP53 CpG mutation hotspot sites including codons 157, 158, 245, 248 and 273. We performed molecular modelling of BPDE-adducted TP53 duplex sequences to determine the degree of local distortion caused by adducts which could influence the ability of nucleotide excision repair. We show that BPDE adducted codon 157 has greater structural distortion than other TP53 G:C>T:A hotspot sites and that sequence context more distal to adjacent bases must influence local distortion. Using TP53 trinucleotide mutation signatures for lung cancer in smokers and non-smokers we further show that codons 157 and 273 have the highest mutation probability in smokers. Combining this information with adduct structural data we predict that G:C>T:A mutations at codon 157 in lung tumours of smokers are predominantly caused by BPDE. Our results provide insight into how different DNA sequence contexts show variability in DNA distortion at mutagen adduct sites that could compromise DNA repair at well characterized cancer related mutation hotspots

Carbon dioxide generation and drawdown during active orogenesis of siliciclastic rocks in the Southern Alps, New Zealand

C.D.M. was supported by NERC CASE PhD studentship award NE/G524160/1 (GNS Science, NZ, CASE partner). D.A.H.T. acknowledges support from research grants NE/H012842/1 and NE/J022128/1 and a Royal Society Wolfson Research Merit Award (WM130051). S.C.C. was funded under GNS Science's “Impacts of Global Plate Tectonics in and around New Zealand Programme” (PGST Contract CO5X0203). J.C.A. was supported by NSF OCE1334758. We also thank Matthew Cooper, Andy Milton, Darryl Green and Lora Wingate for laboratory assistance. We thank Mike Bickle for editorial advice and comments, and reviews from two anonymous reviewers that improved this manuscript.Peer reviewedPublisher PD