8 research outputs found
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Characterization of 11p14-p12 deletion in WAGR syndrome by array CGH for identifying genes contributing to mental retardation and autism
- Publication venue
- Publication date
- 01/12/2008
- Field of study
WAGR (Wilms tumor, Aniridia, Genitourinary malformations and mental Retardation) syndrome is a rare genomic disorder caused by deletion of the 11p14-p12 chromosome region. The majority of WAGR patients have mental retardation and behavioral problems, and more than 20% of the patients also have features of autism. While the Wilms tumor/genitourinary anomalies and aniridia are caused by deletion of WT1 and PAX6 respectively, the genomic cause of mental retardation and autism in WAGR syndrome remains unknown. Using oligonucleotide arrays, we have characterized the 11p14-p12 deletions in 31 patients and identified all the genes involved in each deletion. The deletions had sizes ranging from 4.9 to 23 Mb that encompass 18–62 genes (40 on average). In addition to WT1 and PAX6, all the patients had deletion of PRRG4 (transmembrane gamma-carboxyglutamic acid protein 4). The majority of them had deletion of BDNF (brain-derived neurotrophic factor) and SLC1A2 [solute carrier family 1 (glial high affinity glutamate transporter) member 2]. Deletion of BDNF and SLC1A2 occurred in patients with autism more frequently than in those without autism. Literature review on the functions of the genes suggests that haploinsufficiency of SLC1A2, PRRG4, and BDNF may contribute to mental retardation and behavioral problems. In particular, BDNF may modulate the risk of autism in WAGR patients as suggested by its link with Rett syndrome as a target of MECP2. We observed that all the de novo deletions occurred in the chromosome 11 inherited from the father in the families genotyped, implying a predisposition for de novo mutations occurring in spermatogenesis and possible involvement of imprinting in cognitive impairment in WAGR patients
Habitat preferences of four chironomid species associated with aquatic macrophytes in an irrigation reservoir
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A new window trap used in the assessment of the flight periods of Chironomidae and Simuliidae (Diptera)
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Secondary production of Chironomidae (Diptera) in a north temperate stream
- Author
- Behmer D.J.
- Benke A.C.
- Benke A.C.
- Benke A.C.
- Benke A.C.
- Benke A.C.
- Berg M.B.
- Bode R.W.
- Coffman W.P.
- Coffman W.P.
- Coffman W.P.
- Cudney M.D.
- Devonport B.F.
- Drake C.M.
- Fisher S.G.
- Georgian T.
- Hamilton A.L.
- Hauer F.R.
- Hildrew A.G.
- Hynes H.B.N.
- Illies J.
- Lenat D.R.
- Lenat D.R.
- Lindegaard C.
- Lindegaard C.
- Lindegaard C.
- Mackey A.P.
- Maitland P.S.
- Menzie C.A.
- Neves R.J.
- Pinder L.C.V.
- Pinder L.C.V.
- Pinder L.C.V.
- Resh V.H.
- Schwenneker B.W.
- Schwenneker B.W.
- Sheldon A.L.
- Simpson K.W.
- Singh M.P.
- Waters T.F.
- Waters T.F.
- Waters T.F.
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Environmental impacts of diesel fuel on bacteria and phytoplankton in a tropical estuary assessed using in situ mesocosms
- Author
- A.A.Z. Douabul
- A.J.M. Gonzalez
- A.K. Singh
- A.K. Singh
- B.M. Hanna
- B.M. Mahoney
- B.P.L. Goh
- B.P.L. Goh
- C. Basheer
- C. Basheer
- C.A. Menzie
- C.M. Palmer
- D. Bernard
- D.C. Gordan Jr.
- D.I. Little
- D.W. Connell
- E.C. Chong
- E.C. Chong
- G. Bratbak
- G. Wattayakorn
- G. Witt
- H.H. Soclo
- H.Y. Gin
- I. Orlic
- J. Marra
- J.A. Calder
- J.B. Waterbury
- J.C. Marchand
- J.M. Neff
- J.P. Gaur
- J.W. Anderson
- K. Lee
- K.G. Porter
- K.R. Carman
- K.W. Pontasch
- L.M. Chou
- M. Notar
- M.B. Fernandes
- M.E. Arnegard
- M.G. Commendatore
- M.I. El-Samra
- M.J. Hilton
- M.M. Krahn
- M.P. Abdullah
- MAFF.
- P.A. Hesp
- R. Herrmann
- R. Law
- R.B. Clark
- R.B. Coffin
- R.J. Law
- R.J. Woodhead
- S. McCready
- S. Nayar
- S. Nayar
- S. Nayar
- S.I.C. Hsiao
- S.M. Tang
- S.W. Fowler
- T.A. Hollister
- T.E. Chua
- T.F. Bidleman
- T.F. Thingstad
- T.M. Williams
- U.L. Zweifel
- V.K. Sharma
- W. Rajkumar
- W.M. Dunstan
- X. Zhang
- Y. Qian
- Y.M. Sin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2005
- Field of study
10.1007/s10646-004-6373-8Ecotoxicology143397-412ECOT
POSSIBLE REACTIVE INTERMEDIATES IN THE OXIDATIVE BIOTRANSFORMATION OF HEXACHLOROBENZENE
- Author
- Bauchiiiger M.
- Billi S.C
- Cabral J.R.P.
- Cabral J.R.P.
- Calo V.
- Carpenter H.
- Carpenter H.M.
- Carpenter H.M.
- Courtney K.D.
- Cripps D.J.
- Debets F.M.H.
- Elder G.H.
- Franklin R.B.
- Goerz G.
- Goerz G.
- Goldstein J.
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- Guengerich F.P.
- Jerina D.M.
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- Peters H.A
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- Renner G
- Renner G.
- Renner G.
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- Rios de Molina M.
- Rozman K.
- Sinclair P.R.
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- Smith A.G.
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- Stewart F.P.
- Stonard M.D.
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- Strik J.J.T.W.A
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- Uehleke H.
- Van Ommen B.
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- Vizethum W.
- Vos J.G.
- Vos R.M.E.
- Wainstoek de Calmanovici R
- Wainstok de Calmanovici R.
- White R.E.
- Witte I.
- Publication venue
- 'Walter de Gruyter GmbH'
- Publication date
- Field of study
THE ISO-RENIN ANGIOTENSIN SYSTEMS IN EXTRARENAL TISSUE
- Author
- Allmann D.W.
- Anderson R.C.
- Angles d'Auriac G.
- Bates R.W.
- Berman L.B.
- Blair-West J.R.
- Boucher R.
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- Boyd G.H.
- Capelli J.P.
- Constantinides P.
- Cooling M.J.
- Crocker A.D.
- Davies N.T.
- Davson H.
- Dengler H.
- Erdos E.G.
- Eskildsen P.C.
- Ferrario C.M.
- Ferris T.F.
- Fitzsimons J.T.
- Furth J.
- Ganten D.
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- Ganten D.
- Genest J.
- Goodfriend Th.L.
- Gross F.
- Gutman Y.
- Haas E.
- Hayduk K.
- Hofbauer K.G.
- Hornych A.
- Keil L.C.
- Khairallah P.A.
- Leckie B.
- Marusic E.T.
- Medina A.
- Menzie J.W.
- Michelakis A.M.
- Minnich J.L.
- Morris B.J.
- Mouw D.
- Muller J.
- Munday K.A.
- Olsson K.
- Oparil S.
- Page I.H.
- Palmore W.P.
- Pollay M.
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- Regoli D.
- Saruta T.
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- Tomkins G.M.
- Valtin H.
- Wied D.
- Williams G.H.
- Zimmermann B.G.
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- 'Wiley'
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