Requirement for Protein Synthesis in Adrenocorticotropin Stimulated Steroidogenesis of Isolated Rat Adrenal Cells

A thesis presented to the faculty of the School of Sciences and Mathematics at Morehead State University in partial fulfillment of the requirements for the Degree of Master of Science in Biology by John G. Menke on May 6, 1978

Water resources data for Alachua, Bradford, Clay, and Union Counties, Florida

A study of the water resources of Alachua, Bradford, Clay, and Union counties, Florida (fig. 1), was made by the Water Resources Division of the U. S. Geological Survey in cooperation with the Florida Geological Survey during the period 1957-61. The results of this study will be published by the Florida Geological Survey in the following reports by William E. Clark, Rufus H. Musgrove, Clarence G. Menke, and Joseph W. Cagle, Jr.: "Interim Report on the Water Resources of Alachua, Bradford, Clay, and Union Counties, Florida," "Water Resources of Alachua, Bradford, Clay, and Union Counties, Florida," and "Hydrology of Brooklyn Lake, near Keystone Heights, Florida." (Document has 161 pages.

Digitization of LAr calorimeter for CSC simulations

This note describes the digitization of the LAr signals, which is the step creating RDO from Geant4 Hits, as used during the production of the CSC simulated samples with athena release 12

On the Behavior of the Effective QCD Coupling alpha_tau(s) at Low Scales

The hadronic decays of the tau lepton can be used to determine the effective charge alpha_tau(m^2_tau') for a hypothetical tau-lepton with mass in the range 0 < m_tau' < m_tau. This definition provides a fundamental definition of the QCD coupling at low mass scales. We study the behavior of alpha_tau at low mass scales directly from first principles and without any renormalization-scheme dependence by looking at the experimental data from the OPAL Collaboration. The results are consistent with the freezing of the physical coupling at mass scales s = m^2_tau' of order 1 GeV^2 with a magnitude alpha_tau ~ 0.9 +/- 0.1.Comment: 15 pages, 4 figures, submitted to Physical Review D, added references, some text added, no results nor figures change

Well-Tempered Metadynamics Simulations Predict the Structural and Dynamic Properties of a Chiral 24-Atom Macrocycle in Solution

Inspired by therapeutic potential, the molecular engineering of macrocycles is garnering increased interest. Exercising control with design, however, is challenging due to the dynamic behavior that these molecules must demonstrate in order to be bioactive. Herein, the value of metadynamics simulations is demonstrated: the free-energy surfaces calculated reveal folded and flattened accessible conformations of a 24-atom macrocycle separated by barriers of c.a. 6 kT under experimentally relevant conditions. Simulations reveal that the dominant conformer is folded-an observation consistent with a solid-state structure determined by X-ray crystallography and a network of rOes established by 1H NMR. Simulations suggest that the macrocycle exists as a rapidly interconverting pair of enantiomeric, folded structures. Experimentally, 1H NMR shows a single species at room temperature. However, at lower temperature, the interconversion rate between these enantiomers becomes markedly slower, resulting in the decoalescence of enantiotopic methylene protons into diastereotopic, distinguishable resonances due to the persistence of conformational chirality. The emergence of conformational chirality provides critical experimental support for the simulations, revealing the dynamic nature of the scaffold-a trait deemed critical for oral bioactivity

Subduction beneath Laurentia modified the eastern North American cratonic edge : Evidence from P wave and S wave tomography

Funding Information: NERC Doctoral Training Partnership: Science and Solutions for a Changing Planet and Leverhulme Trust Acknowledgments A.B. is funded by the NERC Doctoral Training Partnership: Science and Solutions for a Changing Planet. I.B. is funded by the Leverhulme Trust. F.D. acknowledges funding from NSERC through their Discovery grants and Canada Research Chairs program. We thank J. VanDecar for use of his tomographic inversion and MCCC codes. SAC [Helffrich et al., 2013] and GMT [Wessel and Smith, 1995] software were also used to process seismic data obtained from the IRIS DMC and from the Canadian National Data Centre (Natural Resources Canada). A digital supplement is also available to download containing models and the processed relative arrival‐time data set, additional information is available from A.B. (email: [email protected]). Discussing the implications of our tomographic results with S. Goes and A. Hynes provided great motivation for this manuscript. Two anonymous reviewers helped clarify our interpretations.Peer reviewedPublisher PD

Mass-luminosity relation for FGK main sequence stars: metallicity and age contributions

The stellar mass-luminosity relation (MLR) is one of the most famous empirical "laws", discovered in the beginning of the 20th century. MLR is still used to estimate stellar masses for nearby stars, particularly for those that are not binary systems, hence the mass cannot be derived directly from the observations. It's well known that the MLR has a statistical dispersion which cannot be explained exclusively due to the observational errors in luminosity (or mass). It is an intrinsic dispersion caused by the differences in age and chemical composition from star to star. In this work we discuss the impact of age and metallicity on the MLR. Using the recent data on mass, luminosity, metallicity, and age for 26 FGK stars (all members of binary systems, with observational mass-errors <= 3%), including the Sun, we derive the MLR taking into account, separately, mass-luminosity, mass-luminosity-metallicity, and mass-luminosity-metallicity-age. Our results show that the inclusion of age and metallicity in the MLR, for FGK stars, improves the individual mass estimation by 5% to 15%.Comment: 7 pages, 4 figures, 1 table, accepted in Astrophysics and Space Scienc

Estimation of the hydraulic parameters of unsaturated samples by electrical resistivity tomography

In situ and laboratory experiments have shown that electrical resistivity tomography (ERT) is an effective tool to image transient phenomena in soils. However, its application in quantifying soil hydraulic parameters has been limited. In this study, experiments of water inflow in unsaturated soil samples were conducted in an oedometer equipped to perform three-dimensional electrical measurements. Reconstructions of the electrical conductivity at different times confirmed the usefulness of ERT for monitoring the evolution of water content. The tomographic reconstructions were subsequently used in conjunction with a finite-element simulation to infer the water retention curve and the unsaturated hydraulic conductivity. The parameters estimated with ERT agree satisfactorily with those determined using established techniques, hence the proposed approach shows good potential for relatively fast characterisations. Similar experiments could be carried out on site to study the hydraulic behaviour of the entire soil deposi

Calorimeter Clustering Algorithms: Description and Performance

This note describes the performance of the calorimeter clustering algorithms used for ATLAS, and which provide inputs for particle identification. ATLAS uses two principal algorithms. The first is the ``sliding-window'' algorithm, which clusters calorimeter cells within fixed-size rectangles; results from this are used for electron, photon, and tau lepton identification. The second is the ``topological'' algorithm, which clusters together neighboring cells, as long as the signal in the cells is significant compared to noise. The results of this second algorithm are further used for jet and missing transverse energy reconstruction. This note first summarizes the steps of the calorimeter reconstruction software. A detailed description of the two clustering algorithms is then given. A last section summarizes their performance. The results presented in this note are obtained with the ATLAS athena software releases 12 and 13