One-pot synthesis of 2-alkyl cycloketones on bifunctional Pd/ZrO₂ catalyst

2-Alkyl cycloketones are essential chemicals and intermediates for synthetic perfumes and pesticides, which are conventionally produced by multistep process including aldol condensation, separation and hydrogenation. In present work, a batch one-pot cascade approach using aldehydes and cycloketones as the raw materials, and a bifunctional Pd/ZrO2 catalyst was developed for the synthesis of 2-alkyl cycloketones, e.g., cyclohexanone and cycloheptanone. Very high aldehydes (except for paraldehyde with large steric hindrance) conversion and high yields for 2-alkyl cycloketones (e.g., 99 % of conversion for n-butanal and 76 wt.% of yield for 2-butyl cyclohexanone) were obtained at mild temperature of 140 °C. After 10 cycles of reuse, Pd/ZrO2 catalyst showed slight deactivation (ca. 5 % conversion and 10 % yield losses), due to the coke on the catalyst. However, the performance of the catalyst was completely recovered after an oxidative regeneration

A New Multi-Objective Comprehensive Optimization Model for Homogeneous Slope Reinforced by Anti-Slide Piles: Insights from Numerical Simulation

AbstractLandslides have posed a huge threat to the ecological environment and human society all over the world. As the most conventional reinforcement method, anti-slide piles are widely used in the reinforcement of slopes. Currently, more and more attention has been paid to the low-cost and high-efficiency optimal design of anti-slide piles. However, limitations in the method of the optimization design for slopes reinforced with piles still exist. In this paper, a new multi-objective comprehensive optimization method was proposed for the optimization of the slope reinforced with anti-slide piles. The factor of safety, internal force, and deflection of piles were selected as the optimization indexes, and the optimization index weight was determined by integrating the subjective and objective weights. The influence of pile locations, pile lengths, and pile spacings on the reinforcement effect of a homogeneous slope was analyzed via the numerical simulation. Through the simulation case analysis, the proposed model had achieved good effects on the optimization design of anti-slide piles, which could effectively reduce the engineering costs. The optimization results showed that the best reinforcement effect for the homogeneous slope could be obtained when the anti-slide piles with the critical pile length and small pile spacing were located in the middle of the slope. This provides a new solution for the optimization design of other types of complex slopes and has broad application prospects

Safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of aficamten in healthy Chinese participants: a randomized, double-blind, placebo-controlled, phase 1 study

Objectives: Aficamten is a selective, small-molecule allosteric inhibitor of cardiac sarcomere being developed as a chronic oral treatment for patients with symptomatic obstructive hypertrophic cardiomyopathy. This was the first-in-Chinese study aiming to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of aficamten in healthy adults.Methods: This double-blind, randomized, placebo-controlled, phase 1 study was conducted in 28 healthy male and female Chinese participants after single ascending dose (SAD) and multi-dose (MD) administrations of aficamten. In the SAD cohort, 16 participants were randomized to receive a single oral dose of aficamten: 10 mg, 20 mg, or placebo. In the MD cohort, 12 participants were randomized to receive multiple doses of aficamten: 5 mg or placebo once daily for 14 days. Safety was monitored throughout the study with electrocardiograms, echocardiograms, clinical laboratory tests, and reporting of adverse events (AEs). Pharmacokinetic profiles of aficamten and metabolites, as well as CYP2D6 genetic impact, were evaluated.Results: A total of 35 treatment-emergent AEs were reported by 14 (50%) participants with mild severity. There were no serious AEs or adverse decreases in left ventricular ejection fraction below 50% during the study. Aficamten was dose-proportional over the dose range of 5–20 mg and accumulated in the MD cohort.Conclusion: Aficamten was safe and well-tolerated in the healthy Chinese adult participants. The pharmacokinetics of aficamten in the Chinese population was comparable to those previously found in Western participants. These phase 1 data support the progression of aficamten into future clinical studies in Chinese patients.Clinical Trial registration:https://clinicaltrials.gov, identifier: NCT04783766

Energy Characteristics of Acoustic Emission at the Volume-Expansion Point of a Rock Bridge: A New Insight into the Evolutionary Mechanism of Coastal Cliff Collapse

The recession of a coast can destabilize coastal cliffs. The stability of a cliff is controlled by a rock bridge. Identifying the volume-expansion point of rock bridges is crucial to assess cliff stability, but currently there are few identifying methods. Using a numerical analytical tool, we investigate the acoustic emission characteristics during shear tests on rock bridges. Acoustic emission events with a high energy level, i.e., characteristic events which occur at the volume-expansion point of rock bridges, can indicate this point. The characteristic events, the mainshock (the maximum event corresponding to rock-bridge rupture), and the smaller events between them constitute a special activity pattern, as the micro-seismicity during the evolutionary process of a coastal cliff collapse in Mesnil-Val, NW France showed. This pattern arises in rock bridges with different mechanical properties and geometry, or under different loading conditions. Although the energy level of characteristic events and mainshocks changes with the variation of the conditions, the difference of their energy level is approximately constant. The spatial distribution of characteristic events and mainshocks can indicate the location of rock bridges. These findings help to better understand the evolutionary mechanism of collapses and provide guidelines for monitoring the stability of coastal cliffs

Energy Characteristics of Acoustic Emission at the Volume-Expansion Point of a Rock Bridge: A New Insight into the Evolutionary Mechanism of Coastal Cliff Collapse

The recession of a coast can destabilize coastal cliffs. The stability of a cliff is controlled by a rock bridge. Identifying the volume-expansion point of rock bridges is crucial to assess cliff stability, but currently there are few identifying methods. Using a numerical analytical tool, we investigate the acoustic emission characteristics during shear tests on rock bridges. Acoustic emission events with a high energy level, i.e., characteristic events which occur at the volume-expansion point of rock bridges, can indicate this point. The characteristic events, the mainshock (the maximum event corresponding to rock-bridge rupture), and the smaller events between them constitute a special activity pattern, as the micro-seismicity during the evolutionary process of a coastal cliff collapse in Mesnil-Val, NW France showed. This pattern arises in rock bridges with different mechanical properties and geometry, or under different loading conditions. Although the energy level of characteristic events and mainshocks changes with the variation of the conditions, the difference of their energy level is approximately constant. The spatial distribution of characteristic events and mainshocks can indicate the location of rock bridges. These findings help to better understand the evolutionary mechanism of collapses and provide guidelines for monitoring the stability of coastal cliffs

A novel multiple attribute decision making method based on q-rung dual hesitant uncertain linguistic sets and Muirhead mean

This paper aims to propose a new multi-attribute decision making (MADM) method in complicated and fuzzy decision-making environment. To express both decision makers (DMs’) quantitative and qualitative evaluation information comprehensively and consider their high hesitancy in giving their assessment values in MADM process, we combine q-rung dual hesitant fuzzy sets (q-RDHFSs) with uncertain linguistic variables and develop a new tool, called the q-rung dual hesitant uncertain linguistic sets (q-RDHULSs). First, the definition, operations and comparison method of q-RDHULSs are proposed. Second, given the interrelationship among multiple q-rung dual hesitant uncertain linguistic variables (q-RDHULVs) we introduce some aggregation operators (AOs) to fuse q-rung dual hesitant uncertain linguistic (q-RDHUL) information based on the Muirhead mean, i.e. the q-RDHUL Muirhead mean operator, the q-RDHUL weighted Muirhead mean operator, the q-RDHUL dual Muirhead mean operator, and the q-RDHUL weighted dual Muirhead mean operator. To cope with MADM problems with q-RDHUL information, we propose a new method based on the proposed AOs. Afterwards, we apply the proposed method to an enterprise informatization level evaluation problem to verify its effectiveness. In addition, we also explain why our proposed method is more powerful and flexible than others

Coal-Based Reduction and Magnetic Separation Behavior of Low-Grade Vanadium-Titanium Magnetite Pellets

Coal-based reduction and magnetic separation behavior of low-grade vanadium-titanium magnetite pellets were studied in this paper. It is found that the metallization degree increased obviously with an increase in the temperature from 1100 °C to 1400 °C. The phase composition transformation was specifically analyzed with X-ray diffraction (XRD). The microscopic examination was carried out with scanning electron microscopy (SEM), and the element composition and distribution were detected with energy dispersive spectroscopy (EDS). It is observed that the amounts of metallic iron particles obviously increased and the accumulation and growing tendency were gradually facilitated with the increase in the temperature from 1100 °C to 1400 °C. It is also found that the titanium oxides were gradually reduced and separated from ferrum-titanium oxides during reduction. In addition, with increasing the temperature from 1200 °C to 1350 °C, silicate phases, especially calcium silicate phases that were transformed from calcium ferrite at 1100 °C, were observed and gradually aggregated. However, at 1400 °C some silicate phases infiltrated into metallic iron, as it appears that the carbides, especially TiC, could probably contribute to the sintering phenomenon becoming serious. The transformation behavior of valuable elements was as follows: Fe2VO4 → VO → V → VC; FeTiO3 (→ FeTi2O5) → TiO2 → TiC; FeCr2O4 → Cr → CrC; FeTiO3 (→ FeTi2O5) → Fe0.5Mg0.5Ti2O5; (Fe3O4/FeTiO3→) FeO → Mg0.77Fe0.23O. Through the magnetic separation of coal-based reduced products, it is demonstrated that the separation of Cr, V, Ti, and non-magnetic phases can be preliminarily realized

Influence of Root Volume, Plant Spacing, and Planting Pattern of Tap-like Tree Root System on Slope Protection Effect

Vegetation slope protection has been widely utilized as an eco-friendly approach for slope stability. Up to now, research on the slope protection effect of shrubs and herbaceous vegetation is more than those of trees, which can be attributed to the challenge of evaluating the slope protection effect of tree root systems that can be influenced by many factors, such as root morphology, root volume, plant spacing, and planting patterns. Therefore, this study takes tap-like tree root systems as the research object, constructs the corresponding root-soil composite model by using 3D printing technology, and carries out a series of physical model experiments on slopes supported by tap-like tree root systems, examining the anti-sliding force, slope surface displacement, sliding range, and slope cracks throughout the entire process of deformation and the damage to shallow slopes, to finally evaluate the effectiveness in the slope protection effect of tree root systems from multiple perspectives. The results indicate that: (1) the peak anti-sliding force of the slope supported by tree root systems correlates positively with the root volume and negatively with plant spacing generally, and the influence of tree plant spacing on the peak anti-sliding force is weaker than that of the root volume; (2) the displacement of slopes supported by tree root systems in the square planting pattern is generally less than that in the staggered planting pattern, and the displacement of slopes has a negative correlation with the root volume and a positive correlation with the plant spacing; (3) the sliding range of the slope supported by tree root systems is significantly reduced compared with that of the unsupported slope, and the tree root system can prevent the occurrence of slope surface cracks to a certain extent, which makes the sliding-body show better integrity. The above understanding enriches the study on the slope protection effect of the tree root system, reveals the influence of the tree root volume, plant spacing, and planting pattern (square distribution and staggered distribution) of the tap-like tree root system, and offers some guidance for the engineering application of tree slope protection in practice

Flexible Resource Allocation-Efficient Water Use Strategies Facilitate Invasion of Invasive Vine <i>Sicyos angulatus</i> L.

The invasive vine Sicyos angulatus L. destroys the natural ecosystem of invaded areas. Understanding the differences in growth and development between S. angulatus and other plants is necessary to explore the invasion mechanisms of S. angulatus and implement appropriate prevention and control measures. Thus, this study compared the growth, photosynthesis, and root characteristics of invasive liana S. angulatus and other three vine plants, Ipomoea nil (L.) Roth, Ipomoea purpurea (L.), and Thladiantha dubia Bunge, at different growth stages: seedling, flowering, and fruiting. The results showed that the total biomass of S. angulatus in the fruiting stage was 3–6 times that of the other three plants, and the root biomass ratio and root–shoot ratio decreased throughout the growth stage. Throughout the growth stage, the total leaf area of S. angulatus was significantly higher than that of the other three plant types, and the specific leaf area of S. angulatus at the seedling and flowering stages was 2.5–3 and 1.4–3 times that of the other three plants, respectively. The photosynthetic rate, stomatal conductance, and transpiration rate of S. angulatus at the fruiting stage were significantly higher than those of the other three plants, and its water use efficiency was higher than that of the other three plants at the three growth stages, indicating its strong photosynthetic capacity. The root activity and root pressure of S. angulatus were also significantly higher than those of the other three plants at the seedling and flowering stages. These results show that S. angulatus flexibly allocates resources to its aboveground parts during the growth stage to ensure that the plant obtains the space necessary for its growth and development and that with the help of higher root pressure and root activity, S. angulatus can maintain higher photosynthesis and water use efficiency with fewer resources. Therefore, the prevention and control of S. angulatus requires a combination of aboveground and underground measures. Spraying conventional weedicide/herbicide and manually removing aboveground plants may lead to its resurgence