Ovarian Hormonal Change-Related Energy Metabolism and Obesity in Menopausal Women

Obesity and its related severe consequences have been a major public health problem worldwide. A significant weight gain and intra-abdominal adipose tissue accumulation are observed as women begin the menopausal transition. A number of clinical and basic research indicate that ovarian hormone may play a crucial role. However, the underlying mechanisms are largely unknown. In this chapter, we aim to systematically review the literature in the influences of ovarian hormone on the physiology of lipid and glucose metabolism, obesity-related hormone, and the regulation of body weight by the dietary intake, feeding behavior. A variety of research modalities have been used to explore the effects of MHT in perimenopausal women. Hence, we will also summarize the latest progress of MHT use on the effect of body mass, body fat redistribution, and insulin resistance, which lead to protective cardiometabolic effects

Catalytically Active Advanced Two-Dimensional Ultrathin Nanomaterials for Sustainable Energy

Advanced two-dimensional (2D) ultrathin nanomaterials’ unique structural and electronic properties and their applications in the photo-, photoelectro-, and electro-catalysis fields present timely topics related to the development of sustainable energy. This critical review briefly summarizes the state-of-the-art progress on 2D ultrathin nanomaterials. In this mini review, we started with the synthesis of 2D ultrathin nanomaterials. Then, various strategies for tailoring the electronic and configuration structures of these nanomaterials in the new energy catalysis field are surveyed, where the emphasis is mainly on structure-activity relationships. The advancements of versatile 2D ultrathin nanomaterials in the fields of hydrogen evolution, carbon dioxide conversion, and dinitrogen fixation for sustainable energy were also discussed. Finally, the existing challenges and future research directions in this promising field are presented

Confrontment and solution to gonadotropin resistance and low oocyte retrieval in in vitro fertilization for type I BPES: a case series with review of literature

Abstract Background FOXL2 mutations in human cause Blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES). While type II BPES solely features eyelid abnormality, type I BPES involves not only eyelid but also ovary, leading to primary ovarian insufficiency (POI) and female infertility. Current mainstream reproductive option for type I BPES is embryo or oocyte donation. Attempts on assisted reproductive technology (ART) aiming biological parenthood in this population were sparse and mostly unsuccessful. Case presentation Two Chinese type I BPES patients with low anti-müllerian hormone (AMH) and elevated follicle stimulating hormone (FSH) presented with primary infertility in their early 30s. Genetic studies confirmed two heterozygous duplication mutations that were never reported previously in East Asian populations. They received in vitro fertilization (IVF) treatment and both exhibited resistance to gonadotropin and difficulty in retrieving oocytes in repeated cycles. Doubled to quadrupled total gonadotropin doses were required to awaken follicular response. Patient 1 delivered a baby girl with the same eyelid phenotype and patient 2 had ongoing live intrauterine pregnancy at the time of manuscript submission. Conclusions This is the second reported live birth of biological offspring in type I BPES patients, and first success using IVF techniques. It confirmed that ART is difficult but feasible in type I BPES. It further alerts clinicians and genetic counsellors to type female BPES patients with caution in view of the precious and potentially narrowed reproductive window

Age and crack length effects on fracture parameters of dam gallery concrete: Experimental investigation and modeling

Cracks of varying lengths may occur in galleries throughout dam construction, operation, and management processes. This study investigates the influence of age and crack length on the fracture parameters of gallery concrete, which is crucial for understanding the mechanisms and risks associated with gallery cracking and for developing appropriate treatment measures. Wedge-splitting tests were performed on gallery concrete specimens with varying crack lengths and at different ages. It was found that the fracture parameters measured at different ages all decrease with the increase of crack length. Based on the test results, size-independent material constants such as fracture toughness and the effective length of the fracture process zone were derived and modeled using an exponential function to reflect their time-varying characteristics. A fracture model was proposed and validated, which can accurately predict the fracture behavior of gallery concrete across varying ages and crack lengths, and is applicable in practical dam gallery crack analysis for assessing crack stability and evaluating the effectiveness of treatment measures

Intermediate-Length GGC Repeat Expansion in NOTCH2NLC Was Identified in Chinese Patients with Amyotrophic Lateral Sclerosis

GGC repeat expansions in the 5’ untranslated region (5’UTR) of the Notch Homolog 2 N-terminal-like C gene (NOTCH2NLC) have been reported to be the genetic cause of neuronal intranuclear inclusion disease (NIID). However, whether they exist in other neurodegenerative disorders remains unclear. To determine whether there is a medium-length amplification of NOTCH2NLC in patients with amyotrophic lateral sclerosis (ALS), we screened 476 ALS patients and 210 healthy controls for the presence of a GGC repeat expansion in NOTCH2NLC by using repeat-primed polymerase chain reaction (RP-PCR) and fragment analysis. The repeat number in ALS patients was 16.11 ± 5.7 (range 7–46), whereas the repeat number in control subjects was 16.19 ± 3.79 (range 10–29). An intermediate-length GGC repeat expansion was observed in two ALS patients (numbers of repeats: 45, 46; normal repeat number ≤ 40) but not in the control group. The results suggested that the intermediate NOTCH2NLC GGC repeat expansion was associated with Chinese ALS patients, and further functional studies for intermediate-length variation are required to identify the mechanism

Facile microwave-assisted ionic liquid synthesis of sphere-like BiOBr hollow and porous nanostructures with enhanced photocatalytic performance

In this work, two kinds of self-assembled hierarchical BiOBr microcrystals were rapidly synthesized through a simple microwave-assisted route in the presence of reactable ionic liquid 1-hexadecyl-3-methylimidazolium bromide ([C16mim]Br). These porous and hollow BiOBr microspheres were obtained via a facile solvothermal method with or without polyvinyl pyrrolidone (PVP), respectively. During the synthetic process, ionic liquid [C16mim]Br played as solvent, reactant and template at the same time. Moreover, the BiOBr hollow and porous microspheres exhibited outstanding photocatalytic activities for the degradation of rhodamine B (RhB) under visible light irradiation. A possible photocatalytic mechanism was also discussed in detail. It can be assumed that the higher photocatalytic activities of BiOBr porous microspheres materials could be ascribed to the novel structure, larger specific surface area, narrower band gap structure and smaller particle size. Keywords: BiOBr, Photocatalytic, Ionic liquid, Microwav

An Apple Fruit Fermentation (AFF) Treatment Improves the Composition of the Rhizosphere Microbial Community and Growth of Strawberry (Fragaria × ananassa Duch 'Benihoppe') Seedlings.

Plant growth can be promoted by the application of apple fruit fermentation (AFF), despite unclear of the underlying mechanisms, the effects involved in AFF on rhizosphere microorganisms have been hypothesized. We investigated the consequences of applying AFF alone or in combination with Bacillus licheniformis to strawberry tissue culture seedlings in vitro, the analyses of Denaturing Gradient Gel Electrophoresis (DGGE) and 16S rDNA were performed to determine AFF effects on rhizosphere. Moreover, the growth index and antioxidant enzyme activities were determined 30 days after treatments. We identified five dominant bacteria in AFF: Coprinus atramentarius, Bacillus megaterium, Bacillus licheniformis, Weissella and B. subtilis. The greatest number of bacterial species were observed in the rhizosphere of control matrix (water treated), and the lowest diversity appeared in the rhizosphere soil treated with 108 cfu/mL B. licheniformis alone. Combining AFF plus B. licheniformis in one treatment resulted in the largest leaf area, plant height, root length, plant weight, and the markedly higher activities of antioxidant enzymes. We conclude that a combination of AFF plus B. licheniformis treatment to matrix can increase antioxidant enzymes activities in strawberry seedlings, optimize the status of rhizosphere microbial, and promote plant growth

Heterostructured Bi-Cu2S nanocrystals for efficient CO2 electroreduction to formate

10.1039/d1nh00661dNANOSCALE HORIZON