Compressed glassy carbon: An ultrastrong and elastic interpenetrating graphene network

Carbon’s unique ability to have both sp2 and sp3 bonding states gives rise to a range of physical attributes, including excellent mechanical and electrical properties. We show that a series of lightweight, ultrastrong, hard, elastic, and conductive carbons are recovered after compressing sp2-hybridized glassy carbon at various temperatures. Compression induces the local buckling of graphene sheets through sp3 nodes to form interpenetrating graphene networks with long-range disorder and short-range order on the nanometer scale. The compressed glassy carbons have extraordinary specific compressive strengths—more than two times that of commonly used ceramics—and simultaneously exhibit robust elastic recovery in response to local deformations. This type of carbon is an optimal ultralight, ultrastrong material for a wide range of multifunctional applications, and the synthesis methodology demonstrates potential to access entirely new metastable materials with exceptional properties

Improving the Transduction Efficiency and Antitumor Effect of Conditionally Replicative Adenovirus by Application of 6-cyclohexyl Methyl-β-D-maltoside

As a tumor-targeting oncolytic adenovirus (Ad), conditionally replicating adenovirus (CRAd) can access the cell interior by binding to coxsackievirus-Ad receptors (CARs) and specifically replicate and destroy cancer cells without lethal effects on normal cells. The transduction efficiency of CRAd is highly dependent on the number of CARs on the cell membrane. However, not all tumor cells highly express CARs; therefore, improving the transduction efficiency of CRAd is beneficial for improving its antitumor effect. In this study, 6-cyclohexyl methyl-β-D-maltoside (6-β-D), as maltoside transfection agent, showed several advantages, including high transfection efficiency, low toxicity, and potential for intensive use and easy operation. With pretreatment of cancer cells with low concentration of 6-β-D (≤5 μg/mL), the transduction efficiency of “model” Ad (eGFP-Ad) was improved 18-fold compared to eGFP-Ad alone. 6-β-D improved the antitumor effect of CRAd while being safe for normal cells, in which treatment with 6-β-D helped the lethal effects of CRAd at a multiplicity-of-infection ratio of 10 (MOI 10) achieve the oncolytic outcomes of MOI 50. This means that if CRAd is combined with 6-β-D, the amount of CRAd used in clinical practice could be greatly reduced without diminishing its curative effect or exposing patients to the potential side effects of high-titer CRAd. Finally, the underlying mechanism of antitumor effect of CRAd + 6-β-D was primarily investigated, and we found that 6-β-D increased the virus’s replication in cancer cells at the early stage of infection and activated the apoptosis signaling pathway at the late stage of the cell cycle. This research will provide an effective technical reference for further improving Ad-mediated cancer gene therapy in clinical practice

Is the ‘water tower’ reassuring? Viewing water security of Qinghai-Tibet Plateau from the perspective of ecosystem services ‘supply-flow-demand’

Ecosystem service flow plays a vital role in the formation, transportation, transformation, and maintenance of ecosystem services. For ecosystem services with spatiotemporal mismatch of supply and demand, ecosystem service flow explains the integrated process of ‘supply-flow-demand’ of ecosystem services. The present study evaluates the supply and demand of ecosystem water provision services in the Qinghai-Tibet Plateau and simulates the spatial flow pattern and transmission mechanism of water provision services. Additionally, the study establishes dynamic and static water security indices and identify water security level to quantify the water resources security of Qinghai-Tibet Plateau under the changing ecological environment. The research shows: (a) the annual total water surplus were 6.71 × 10 ^11 m ^3 , 8.43 × 10 ^11 m ^3 , 7.86 × 10 ^11 m ^3 and 2.91 × 10 ^11 m ^3 . The supply–demand relationship of water provisioning service in the Qinghai-Tibet Plateau shows an obvious oversupply condition; (b) The water security level of the plateau is high (level V and level IV), indicating that the water security status of the Qinghai- Tibet Plateau is under good condition, however, the area with low-security levels (Level I and Level II) is increasing. (c) From the perspective of ‘supply-demand-flow’ of ecosystem services, although the function of the water tower on the Qinghai Tibet Plateau has declined, it remained safe condition on the whole study area. The method of establishing spatial correlation between mismatched supply and demand of ecosystem services and evaluating regional water security based on ecosystem service flow constructed in this study presents the water security status and spatial distribution of Qinghai-Tibet Plateau more scientifically, providing a reference for water resource management in other regions

A VIRTUAL BRAIN FOR STEREOTACTIC PLANNING AND SUPPORTING NEUROSURGERY

International audienceVisualization has becoming a powerful assistive technology for neurosurgery. This paperintroduces a system for stereotactic neurosurgical planning and support. Using visualizationtechnology the system reconstructs and displays a 3D model of the interior structure of thepatient’s brain. Thus the surgeons can plan for surgery using a computer model. Markerregistration is used to create the mapping between the patient’s head and the brain modelreconstructed in the computer. During the operation a robot arm is used as a navigator to locatethe pre-defined incision site and the orientation of incision route. When the robot arm locates atthe pre-defined site on the patient’s head, it is fixed. Various medical instruments can be installedon the tip of the robot arm. The surgeon can insert a medical instrument into the pre-defined siteof the patient’s head, and the surgery can be implemented successfully with the help of thissystem. Using a virtual environment his system can also be used to teach and train new surgeons

Spatial Layout of Cotton Seed Production Based on Hierarchical Classification: A Case Study in Xinjiang, China

Cotton seed production is the main form of agriculture in Xinjiang, China. Unreasonable distribution of cotton seed production results in a waste of water, land, and human resources. In this study, we established a hierarchical classification integrating method; investigated the spatial suitability of climate, land and water resources, and infrastructure; examined the production risk and planting history; and integrated spatial suitability and production risk and history to produce the spatial layout of seed production for early-maturing cotton (EMC), early–medium-maturing cotton (EMMC), and long staple cotton (LSC) in Xinjiang. The results indicated that the appropriate areas for EMC, EMMC, and LSC seed production are 6.4 × 105, 5.5 × 105, and 3.6 × 105 ha, respectively. By combining the suitable areas of seed production for the three cotton species, we concluded that the superior and most suitable area for producing cotton seed of EMC, EMMC, or LSC is located in the western Tarim Basin. The sub-suitable area for cotton seed production of EMC, EMMC, or LSC is mostly distributed in the western and northern Tarim Basin. This research provides a good solution to the selection of cotton seed production base; however, adoption will depend on the actual preference and market factors

Fractal model of shear-induced rough fracture flow by cross-scale description of its geometry

The Beishan area in Gansu province is the main pre-selected site for deep geological disposal of high-level radioactive waste, it therefore bears implications for the study of fracture seepage characteristics of granite caused by shear failure. This paper investigated the fractal modeling of the geometric and seepage characteristics of granite fracture sections under shear conditions, with the aim to explore the effect of the geometric characteristics of multi-scale rough fractures on the evolution of nonlinear seepage field in Beishan granite. Results show that the roughness height and aperture of rough fractures have complete self-similarity in the process of model scale change, whose distribution are always consistent in the process of spatial scale change. The seepage velocity field, gradient field and divergence field only demonstrate the continuation of local characteristics, in particular, the corresponding quantity fields at different scales are subject to normal distribution. As the observation scale increases, the spatial fluctuation in the field gradually decreases, the sharp mutations in the three fields gradually disappear and are smoothed. This indicates that the larger the observation scale, the greater the probability that the seepage of rough fracture is misjudged as the seepage of parallel plate, therefore the seepage characteristics of rough section would be more accurately described by taking the geometric scale into account

3D hybrid carbon composed of multigraphene bridged by carbon chains

The element carbon possesses various stable and metastable allotropes; some of them have been applied in diverse fields. The experimental evidences of both carbon chain and graphdiyne have been reported. Here, we reveal the mystery of an enchanting carbon allotrope with sp-, sp2-, and sp3-hybridized carbon atoms using a newly developed ab initio particle-swarm optimization algorithm for crystal structure prediction. This crystalline allotrope, namely m-C12, can be viewed as braided mesh architecture interwoven with multigraphene and carbon chains. The m-C12 meets the criteria for dynamic and mechanical stabilities and is energetically more stable than carbyne and graphdiyne. Analysis of the B/G and Poisson’s ratio indicates that this allotrope is ductile. Notably, m-C12 is a superconducting carbon with Tc of 1.13 K, which is rare in the family of carbon allotropes

In Situ Collection and Rapid Detection of Pathogenic Bacteria Using a Flexible SERS Platform Combined with a Portable Raman Spectrometer

This study aims to develop a simple, sensitive, low-cost, environmentally friendly and flexible surface-enhanced Raman scattering (SERS) platform, combined with a portable Raman spectrometer, for the rapid and on-site SERS detection of bacteria. Commercial tobacco packaging paper (TPP) with little background interference was used as a loading medium that effectively adsorbed Au nanoparticles and provided sufficient “hot spots”. This Au-tobacco packaging paper (Au-TPP) substrate used as a flexible SERS platform can maximize sample collection by wiping irregular surfaces, and was successfully applied to the on-site and rapid detection of pathogenic bacteria. Raman fingerprints of pathogenic bacteria can be obtained by SERS detection of spiked pork using wipeable Au-TPP, which verifies its value in practical applications. The results collected by SERS were further verified by polymerase chain reaction (PCR) results. It showed several advantages in on-site SERS detection, including accurate discrimination, simple preparation, easy operation, good sensitivity, accuracy and reproducibility. This study indicates that the established flexible SERS platform has good practical applications in pathogenic bacterial identification and other rapid detections