1,486 research outputs found
Motivated to Gain: Awareness of an Impending Ending and the Ending Effect
The ending effect describes the phenomenon that individuals are more risk-taking during the final round of a series of risky decision tasks. Previous research suggests that the ending effect might be caused by a motivational shift induced by changes in time perception. However, none of the existing research directly tested the motivational state immediately before the last round of a series of risky decision tasks. To fill in this gap of knowledge, the present study tested whether this motivational shift indeed occurs immediately before the last round. All participants worked on 11 rounds of risky decision tasks, half of them knew that the decision tasks included 11 rounds, whereas the other half did not know. Before the last round of the risky decision tasks, all participants completed a visual reaction time task. It was found that, compared with participants who were not aware of the impending ending, those who knew they were approaching the last round responded to peripherally located character strings appearing immediately after gain-related words slower than those appearing after loss-related words, suggesting that perceived endings lead participants to be more motivated toward gaining rewards. This work provides critical evidence which supports the motivational account of the ending effect proposed in previous research. Such a finding would represent a next step in unpacking the psychological consequences of perceived endings in everyday life
Enhanced Stem Cell Osteogenic Differentiation by Bioactive Glass Functionalized Graphene Oxide Substrates
An unmet need in engineered bone regeneration is to develop scaffolds capable of manipulating stem cells osteogenesis. Graphene oxide (GO) has been widely used as a biomaterial for various biomedical applications. However, it remains challenging to functionalize GO as ideal platform for specifically directing stem cell osteogenesis. Herein, we report facile functionalization of GO with dopamine and subsequent bioactive glass (BG) to enhance stem cell adhesion, spreading, and osteogenic differentiation. On the basis of graphene, we obtained dopamine functionalized graphene oxide/bioactive glass (DGO/BG) hybrid scaffolds containing different content of DGO by loading BG nanoparticles on graphene oxide surface using sol-gel method. To enhance the dispersion stability and facilitate subsequent nucleation of BG in GO, firstly, dopamine (DA) was used to modify GO. Then, the modified GO was functionalized with bioactive glass (BG) using sol-gel method. The adhesion, spreading, and osteoinductive effects of DGO/BG scaffold on rat bone marrow mesenchymal stem cells (rBMSCs) were evaluated. DGO/BG hybrid scaffolds with different content of DGO could influence rBMSCsâ behavior. The highest expression level of osteogenic markers suggests that the DGO/BG hybrid scaffolds have great potential or elicit desired bone reparative outcome
Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host
Taenia saginata, Taenia solium and Taenia asiatica (beef, pork and Asian tapeworms, respectively) are parasitic flatworms of major public health and food safety importance. Among them, T. asiatica is a newly recognized species that split from T. saginata via an intermediate host switch âŒ1.14 Myr ago. Here we report the 169- and 168-Mb draft genomes of T. saginata and T. asiatica. Comparative analysis reveals that high rates of gene duplications and functional diversifications might have partially driven the divergence between T. asiatica and T. saginata. We observe accelerated evolutionary rates, adaptive evolutions in homeostasis regulation, tegument maintenance and lipid uptakes, and differential/specialized gene family expansions in T. asiatica that may favour its hepatotropism in the new intermediate host. We also identify potential targets for developing diagnostic or intervention tools against human tapeworms. These data provide new insights into the evolution of Taenia parasites, particularly the recent speciation of T. asiatica
Parallel momentum distribution of the Si fragments from P
Distribution of the parallel momentum of Si fragments from the breakup
of 30.7 MeV/nucleon P has been measured on C targets. The distribution
has the FWHM with the value of 110.5 23.5 MeV/c which is consistent
quantitatively with Galuber model calculation assuming by a valence proton in
P. The density distribution is also predicted by Skyrme-Hartree-Fock
calculation. Results show that there might exist the proton-skin structure in
P.Comment: 4 pages, 4 figure
5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding
Funding Information: The investigators were supported by grants from the NIH (R01DK114279, R01DK109934, and R21NS108091 to QT; R01ES027544 and R01DK111436 to ZS; R00DK107008 to PX; R01DK109194 and R56DK109194 to QW; P01DK113954, R01DK115761, R01DK117281, and R01DK125480 to YX; R01DK120858 to QT and YX; K01DK119471 to CW; and P20GM135002 to YH), USDA/CRIS (51000-064-01 S to YX and QW), American Diabetes Association (1-17-PDF-138 to YH, 7-13-JF-61 to QW, and 1-15-BS-184 to QT), American Heart Association awards (16POST27260254 to CW), the Pew Charitable Trust awards to QW (0026188), Baylor Collaborative Faculty Research Investment Program grants to QW, the Faculty Start-up grants from USDA/ ARS to QW, the Biotechnology and Biological Sciences Research Council (BB/ K001418/1 and BB/NO17838/1 to LKH), and the Medical Research Council (MC/PC/ 15077 to LKH). QW is the Pew Scholar of Biomedical Sciences and the Kavli Scholar. The anxiety tests (e.g., open-field test, lightâdark test, and elevated plus maze test) were performed in the Mouse Neurobehavior Core, Baylor College of Medicine, which was supported by National Institutes of Health Grant No. P30HD024064. The Ad-iN/ WED virus was kindly provided by Dr. Martin Myers (University of Michigan). The AAV9-CBA-DIO-WGA-zsGreen virus was kindly provided by Dr. Richard Palmiter (University of Washington).Peer reviewedPublisher PD
Effects of long memory in the order submission process on the properties of recurrence intervals of large price fluctuations
Understanding the statistical properties of recurrence intervals of extreme
events is crucial to risk assessment and management of complex systems. The
probability distributions and correlations of recurrence intervals for many
systems have been extensively investigated. However, the impacts of microscopic
rules of a complex system on the macroscopic properties of its recurrence
intervals are less studied. In this Letter, we adopt an order-driven stock
market model to address this issue for stock returns. We find that the
distributions of the scaled recurrence intervals of simulated returns have a
power law scaling with stretched exponential cutoff and the intervals possess
multifractal nature, which are consistent with empirical results. We further
investigate the effects of long memory in the directions (or signs) and
relative prices of the order flow on the characteristic quantities of these
properties. It is found that the long memory in the order directions (Hurst
index ) has a negligible effect on the interval distributions and the
multifractal nature. In contrast, the power-law exponent of the interval
distribution increases linearly with respect to the Hurst index of the
relative prices, and the singularity width of the multifractal nature
fluctuates around a constant value when and then increases with
. No evident effects of and are found on the long memory of
the recurrence intervals. Our results indicate that the nontrivial properties
of the recurrence intervals of returns are mainly caused by traders' behaviors
of persistently placing new orders around the best bid and ask prices.Comment: 6 EPL pages including 6 figure
Observation of electron-antineutrino disappearance at Daya Bay
The Daya Bay Reactor Neutrino Experiment has measured a non-zero value for
the neutrino mixing angle with a significance of 5.2 standard
deviations. Antineutrinos from six 2.9 GW reactors were detected in
six antineutrino detectors deployed in two near (flux-weighted baseline 470 m
and 576 m) and one far (1648 m) underground experimental halls. With a 43,000
ton-GW_{\rm th}-day livetime exposure in 55 days, 10416 (80376) electron
antineutrino candidates were detected at the far hall (near halls). The ratio
of the observed to expected number of antineutrinos at the far hall is
. A rate-only analysis
finds in a
three-neutrino framework.Comment: 5 figures. Version to appear in Phys. Rev. Let
Search for the decay
We search for radiative decays into a weakly interacting neutral
particle, namely an invisible particle, using the produced through the
process in a data sample of
decays collected by the BESIII detector
at BEPCII. No significant signal is observed. Using a modified frequentist
method, upper limits on the branching fractions are set under different
assumptions of invisible particle masses up to 1.2 . The upper limit corresponding to an invisible particle with zero mass
is 7.0 at the 90\% confidence level
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