Scaling invariance of spatial autocorrelation in urban built-up area

City is proved to be a scale-free phenomenon, and spatial autocorrelation is often employed to analyze spatial redundancy of cities. Unfortunately, spatial analysis results deviated practical requirement in many cases due to fractal nature of cities. This paper is devoted to revealing the internal relationship between the scale dependence of Moran's I and fractal scaling. Mathematical reasoning and empirical analysis are employed to derive and test the model on the scale dependence of spatial autocorrelation. The data extraction way for fractal dimension estimation is box-counting method, and parameter estimation relies on the least squares regression. In light of the locality postulate of spatial correlation and the idea of multifractals, a power law model on Moran's I changing with measurement scale is derived from the principle of recursive subdivision of space. The power exponent is proved to be a function of fractal dimension. This suggests that the numerical relationship between Moran's I and fractal dimension can be established through the scaling process of granularity. An empirical analysis is made to testify the theoretical model. It can be concluded that spatial autocorrelation of urban built-up area has no characteristic scale in many cases, and urban spatial analysis need new thinking.Comment: 25 pages, 6 figures, 5 table

Innovative Design of an Elliptical Trainer with Right Timing of the Foot Trajectory

The existing elliptical trainer cannot provide the user with the real jogging exercising mode and does not meet the principles of ergonomics. The purpose of this paper is to propose and study an innovative elliptical trainer that imitates the right timing of the foot trajectory while jogging. First of all, this study proposes and illustrates the structure and function of the innovative elliptical trainer with quick-return effect. Then, by using vector-loop method and motion geometry of the mechanism, the proposed innovative mechanism is studied kinematically. A design example is presented for interpreting the design process. At last, the foot trajectory of the innovative elliptical trainer is analyzed and confirmed. The simulation results confirm that the timing of the foot trajectory of the foot support members satisfies the principles of ergonomics, and keeps the user’s legs from injury

The Fundamental and Application of Surface Heat Flux Estimation by Inverse Method in Cryogen Spray Cooling

Surface heat flux is an important parameter in various industrial applications, which is often estimated based on measured temperature by solving inverse heat conduction problem (IHCP). In this chapter, the available IHCP methods including sequential function specification (SFS), transfer function (TF) and Duhamel’s theorem were compared, taking the example of surface heat flux estimation during spray cooling. The Duhamel’s theorem was improved to solve 1D multi-layer ICHP. Considering the significant nonuniformity of heat transfer, the 2D filter solution method was proposed to estimate surface heat flux for 2D multi-layer mediums. The maximum heat flux calculated by the 1D method was underestimated by 60% than that calculated by 2D filter solution, indicating that the lateral heat transfer cannot be ignored. The cooling performances based on 2D filter solution demonstrated that substituting the environment friendly R1234yf for R134a can remarkably reduce global warming potential to <1, but its cooling capacity is insufficient. The effective heat flux of R1234yf can be enhanced by 18.8% by reducing the nozzle diameter and decreasing the back pressure, providing the theoretical basis for the clinical potential substitution of R1234yf with low global warming potential (GWP) for commercial R134a with high GWP in laser dermatology

Cell-free Circulating miRNA Biomarkers in Cancer.

Considerable attention and an enormous amount of resources have been dedicated to cancer biomarker discovery and validation. However, there are still a limited number of useful biomarkers available for clinical use. An ideal biomarker should be easily assayed with minimally invasive medical procedures but possess high sensitivity and specificity. Commonly used circulating biomarkers are proteins in serum, most of which require labor-intensive analysis hindered by low sensitivity in early tumor detection. Since the deregulation of microRNA (miRNA) is associated with cancer development and progression, profiling of circulating miRNAs has been used in a number of studies to identify novel minimally invasive miRNA biomarkers. In this review, we discuss the origin of the circulating cell-free miRNAs and their carriers in blood. We summarize the clinical use and function of potentially promising miRNA biomarkers in a variety of different cancers, along with their downstream target genes in tumor initiation and development. Additionally, we analyze some technical challenges in applying miRNA biomarkers to clinical practice

Decrease of Klotho in the Kidney of Streptozotocin-Induced Diabetic Rats

The klotho gene is expressed in a limited number of tissues, most notably in distal convoluted tubules in the kidney and choroid plexus in the brain. A previous study suggested that Klotho increases resistance to oxidative stress. However, changes of Klotho expression in high glucose-induced oxidative stress remain unclear. In the present study, we used streptozotocin-induced diabetic rats (STZ rats) to examine the effects of insulin, phloridzin or antioxidant, tiron on diabetic nephropathy. Both insulin and phloridzin reversed the lower Klotho expression levels in kidneys of STZ rats by the correction of hyperglycemia. Also, renal functions were improved by these treatments. In addition to the improvement of renal functions, the decrease of Klotho expression in kidney of STZ rats was also reversed by tiron without changing blood glucose levels. The reduction of oxidative stress induced by high glucose can be considered for this action of tiron. This view was further confirmed in vitro using high glucose-exposed Madin-Darby canine kidney (MDCK) epithelial cells. Thus, we suggest that decrease of oxidative stress is not only responsible for the improvement of renal function but also for the recovery of Klotho expression in kidney of STZ rats