Zc(3900)Z_c(3900) as a DDˉ∗D\bar{D}^* molecule from the pole counting rule

A comprehensive study on the nature of the $Z_c(3900)$ resonant structure is carried out in this work. By constructing the pertinent effective Lagrangians and considering the important final-state-interaction effects, we first give a unified description to all the relevant experimental data available, including the $J/\psi\pi$ and $\pi\pi$ invariant mass distributions from the $e^+e^-\to J/\psi\pi\pi$ process, the $h_c\pi$ distribution from $e^+e^-\to h_c\pi\pi$ and also the $D\bar D^{*}$ spectrum in the $e^+e^-\to D\bar D^{*}\pi$ process. After fitting the unknown parameters to the previous data, we search the pole in the complex energy plane and find only one pole in the nearby energy region in different Riemann sheets. Therefore we conclude that $Z_c(3900)$ is of $D\bar D^*$ molecular nature, according to the pole counting rule method~[Nucl.~Phys.~A543, 632 (1992); Phys.~Rev.~D 35,~1633 (1987)]. We emphasize that the conclusion based upon the pole counting method is not trivial, since both the $D\bar D^{*}$ contact interactions and the explicit $Z_c$ exchanges are introduced in our analyses and they lead to the same conclusion.Comment: 21 pages, 9 figures. To match the published version in PRD. Additional discussion on the spectral density function is include

MicroRNA-140-5p inhibits cellular proliferation, migration and invasion by downregulating AKT/STAT3/NF-κB pathway in breast carcinoma cells

MicroRNA-140-5p (miR-140-5p) plays a pivotal role in human cancers. However, its role and molecular mechanisms in breast carcinoma are not fully explored. Using miR-140-5p transfected breast cancer cell line MDA-MB-231, several in vitro experiments were performed and described in this paper. They consist of the cell proliferation assay, wound healing assay, transwell assay, colony formation assays and qRTPCR. Expression levels of target proteins were determined using western blotting. In addition, experiments on animal models were performed to study the possible role of miR-140-5p in tumorigenesis of breast carcinoma cells. The induction of experimental breast tumor in mice model was achieved through the incorporation of MDA-MB-231 tumor cells subcutaneously into the middle left side of the mice. The results showed that miR-140-5p up-regulation significantly suppresses proliferation, cellular invasion and migration of breast carcinoma cells. Furthermore, miR-140-5p up-regulation stops breast cancer cells at G0/G1 phase. The results of the animal model indicated that up-regulation of miR-140-5p suppresses its tumorigenic ability. Moreover, we also found that miR-140-5p up-regulation reduces the phosphorylation level of STAT3, p65, and AKT. In addition, miR-140-5p overexpression significantly decreases CDK2 expression while increasing E-cadherin expression level. These data revealed that miR-140-5p suppressed tumor progression of breast carcinoma cells through inhibition of the AKT/STAT3/NF-κB pathway. Taken the present study results together, we can conclude that miR-140-5p may act as a novel target in microRNA-targeting anticancer strategy for the treatment of breast cancer

Isolation, identification, and complete genome sequence of a bovine adenovirus type 3 from cattle in China

<p>Abstract</p> <p>Background</p> <p>Bovine adenovirus type 3 (BAV-3) belongs to the <it>Mastadenovirus </it>genus of the family <it>Adenoviridae </it>and is involved in respiratory and enteric infections of calves. The isolation of BAV-3 has not been reported prior to this study in China. In 2009, there were many cases in cattle showing similar clinical signs to BAV-3 infection and a virus strain, showing cytopathic effect in Madin-Darby bovine kidney cells, was isolated from a bovine nasal swab collected from feedlot cattle in Heilongjiang Province, China. The isolate was confirmed as a bovine adenovirus type 3 by PCR and immunofluorescence assay, and named as HLJ0955. So far only the complete genome sequence of prototype of BAV-3 WBR-1 strain has been reported. In order to further characterize the Chinese isolate HLJ0955, the complete genome sequence of HLJ0955 was determined.</p> <p>Results</p> <p>The size of the genome of the Chinese isolate HLJ0955 is 34,132 nucleotides in length with a G+C content of 53.6%. The coding sequences for gene regions of HLJ0955 isolate were similar to the prototype of BAV-3 WBR-1 strain, with 80.0-98.6% nucleotide and 87.5-98.8% amino acid identities. The genome of HLJ0955 strain contains 16 regions and four deletions in inverted terminal repeats, E1B region and E4 region, respectively. The complete genome and DNA binding protein gene based phylogenetic analysis with other adenoviruses were performed and the results showed that HLJ0955 isolate belonged to BAV-3 and clustered within the <it>Mastadenovirus </it>genus of the family <it>Adenoviridae</it>.</p> <p>Conclusions</p> <p>This is the first study to report the isolation and molecular characterization of BAV-3 from cattle in China. The phylogenetic analysis performed in this study supported the use of the DNA binding protein gene of adenovirus as an appropriate subgenomic target for the classification of different genuses of the family <it>Adenoviridae </it>on the molecular basis. Meanwhile, a large-scale pathogen and serological epidemiological investigations for BVA-3 infection might be carried out in cattle in China. This report will be a good beginning for further studies on BAV-3 in China.</p

The Design and Analysis of Passive Pitch Control for Horizontal Axis Wind Turbine

AbstractThe purpose of this thesis is to design and analysis of passive pitch control. Design a mechanics to control different revolution of blade's pitch angle. The use of small wind turbines gradually popularization, but how to overcome the low wind speed start-up and the operation under high wind speed, that is the difficult problems encountered by designers. In order to extend the use and the safe of wind speed, this design is required. This paper is focus on the mechanism design of the passive pitch control for the small horizontal axis wind turbine (HAWT). When the wind speed is fast, the rotation speed is also faster and faster. The system uses centrifugal force to make Pulley disk driven the pitch angle of the blade. It can achieve the effect of passive pitch control. The mechanism is our laboratory's patent. Through the experiments in wind tunnel, it can be observed the variation of the performance curve when the pitch rotation. This system not only successfully operates under high wind speed but also has better performance at low wind speed