PO-068 Influence of different intensity exercise on immune factor in the hot and humid environment

Objective  to study the influence of exercise on immune factor IL-2、IL-3、IL-6 in the hot and humid environment by comparing the changes of leukocytes after different intensity exercise with the normal environment，exploring the training program which is beneficial for the immune system in the hot and humid environment, and supply the theoretical basis for the sports training and National Physical Fitness in the hot and humid area. Methods The experimental subjects were 32 healthy male college students of Guangzhou Sports with an average age of 20.9 years. All the subjects tested the maximum oxygen uptake before the experiment, and then were divided into the control group, the 55%VO2max sports group, the 70%VO2max sports group and the 85%VO2max sports group. The experimental subjects took a treadmill running in the normal environment(20-25℃;RH: 55-60%) and finished the same exercise training program in the hot and humid environment(30-32℃；RH：90-95%) after a week, collected the elbow venous blood before and after exercise in the normal environment, The main test indicator contained IL-2、IL-3 and IL-6, Training program: control group sit quietly for 30 min;  The 55%VO2max group: Movement×2, 15min one time, Interval 5 min; The 70% VO2max group: Movement×3, 10min one time , Interval 5 min; The 85%VO2max group: Movement ×4, 7.5 min one time , Interval 5 min; All data were calculated using SPSS 25.0, Mean + / - standard deviation (Mean + / - SD), paired T test, single factor variance and multifactor variance analysis. P<0.05 was the significant level, and P<0.01 was the very significant level. Results 1、IL-2 is mainly produced in activated T lymphocytes, which can promote T cell proliferation, improve the secretion and function level of NK cells, play an important role in immune regulation and is an important regulatory factor. Under normal circumstances, IL-2 of the body of each exercise group increased slightly after acute exercise, but there was no statistical significance (p>0.05). In the humid and hot environment, IL-2 decreased in all groups after exercise, and the decrease in the quiet group was large, but there was no statistical significance(p>0.05).2、IL-3 is a multipotent hematopoietic regulatory factor that ACTS on the proliferation and differentiation of hematopoietic cells, mainly produced by activated T lymphocytes. Under normal circumstances, the IL-3 increase of 55% VO2max and 85% VO2max group was not obvious after exercise, while that of 70% VO2max group was not obvious before and after exercise. After acute exercise in hot and humid environment, IL-3 increased in all groups, but there was no statistical significance(p>0.05). Compared with the normal environment, IL-3 increased after exercise in each group.3、IL-6 plays an important role in the regulation of motor mediated function, known as kinematic factor, mainly from stimulated mononuclear macrophages, fibroblasts and vascular endothelial cells. Skeletal muscle can also express IL-6 under exercise stress, which is involved in the repair of muscle cell injury and plays an important regulatory role in skeletal muscle metabolism. Under normal circumstances, after exercise, there was a significant increase in all the exercise groups, among which 55% of the VO2max group and 70% of the VO2max group had a significant difference in IL-6 before and after exercise (p<0.05), and 85% of the VO2max group had a very significant difference (p<0.01). In the humid and hot environment, IL-6 increased after thermal stress in the quiet group, and IL-6 increased significantly after acute exercise in all the exercise groups (p<0.01). Compared with the normal environment, IL-6 increased more significantly and significantly in each group after exercise. Conclusions  The combined effect of heat stress and exercise stress on human immune function in the thermal environment is more significant than that of heat stress or exercise stress alone. The greater the intensity of exercise, the decrease of IL-2 and the significant change of IL-6, the more attention should be paid to the temporary immunosuppression caused by excessive intensity of exercise in the humid and hot environment

To See is to Believe: Prompting GPT-4V for Better Visual Instruction Tuning

Existing visual instruction tuning methods typically prompt large language models with textual descriptions to generate instruction-following data. Despite the promising performance achieved, these descriptions are derived from image annotations, which are oftentimes coarse-grained. Furthermore, the instructions might even contradict the visual content without observing the entire visual context. To address this challenge, we introduce a fine-grained visual instruction dataset, LVIS-Instruct4V, which contains 220K visually aligned and context-aware instructions produced by prompting the powerful GPT-4V with images from LVIS. Through experimental validation and case studies, we demonstrate that high-quality visual instructional data could improve the performance of LLaVA-1.5, a state-of-the-art large multimodal model, across a wide spectrum of benchmarks by clear margins. Notably, by simply replacing the LLaVA-Instruct with our LVIS-Instruct4V, we achieve better results than LLaVA on most challenging LMM benchmarks, e.g., LLaVA$^w$ (76.7 vs. 70.7) and MM-Vet (40.2 vs. 35.4). We release our data and model at https://github.com/X2FD/LVIS-INSTRUCT4V.Comment: techical report; work in progres

PO-066 The Function of t Lycium Barbarum Juice Supplemen in Exercise Stress Regulation during Increasing Resistance Training

Objective The purpose of this study was to explore the function of Lycium Barbarum juice on exercise stress regulation when male university students drank Lycium Barbarum juice during increasing resistance exercise, by observing the effects of oral Lycium Barbarum juice on the blood glucose, serum Adrenocorticotropic Hormone (ACTH), insulin and glucagon concentration. Methods 21 to 22, healthy, 28 male university students participated in the study. They were randomly divided into a control group (n=16)and an experimental group(n=12). All participants completed four-stage incremental load movement for a total of 32 days. The exercise intensity of four stages was 60% VO2max, 70% VO2max, 80% VO2max and 90% VO2max, respectively. Each stage was exercised every-other-day, 4 times per stage and 1 hour each time. During the exercise, each subject in the experimental group drank 100 ml of 100% Lycium Barbarum juice before going to bed every day. Before the experiment and the morning after the end of each phase, a participant’s elbow-venous blood was collected to separate the serum. In all serum substances, the concentrations of ACTH, insulin, glucagon were detected by ELISA system. Fasting blood glucose concentration was detected by a blood glucose meter (Kyoto GT-1640 glucose meter, Japan). SPSS 17.0 software was used for statistical analysis. Results 1) The serum ACTH concentration of the subjects continually increased with the progress of the incremental load exercise and reached the highest at the end of the fourth stage. Compared with the increase in the control group (P<0.05), the experimental group was more significant (P<0.01). 2) Compared with before the experiment, both control group and experimental group were no obvious changes of blood glucose concentration in the first and second stages, and the control group was significantly decreased in the third and fourth stages (P<0.05), while the experimental group was not (P>0.05). 3) During the increasing load exercise, the changes of insulin in serum of the participants were basically the same. The insulin level increased significantly at the end of the first stage and decreased successively at the end of the last three stages. At the end of the fourth stage, the serum insulin level of the control group decreased more significantly (P<0.05) than the experimental group (P>0.05). 4) The glucagon concentration in the control group continued to increase with the increase of the load. By contrast, the glucagon concentration in the experimental group gradually decreased at the end of the first stage and then increased at the end of the fourth stage. However, all of the increase and decrease are not statistically significant. Conclusions During increasing resistance exercise, drinking Lycium Barbarum juice can increase the ability of the body to regulate Adrenocorticotropic Hormone (ACTH), insulin and glucagon through the exercise stress regulation systems, the Hypothalamic-Pituitary-Adrenal Cortical Hormone system (HPA) and the Sympathetic-Adrenal Medullary system. It plays an important role in maintaining blood sugar levels during increasing resistance exercise and accelerating post-exercise function recovery after exercise