Rural poverty reduction strategy for South Asia

Roughly 40 percent of the worlds poor live in South Asia, where poverty is basically a rural problem. Therefore, a significant gain in rural poverty reduction in this sub-region will be crucial to reach the international poverty reduction target. Based on the analysis and experience of the International Fund for Agricultural Development (IFAD), this paper argues that to be successful, poverty reduction policies in South Asia must focus on the less-favoured rural areas and on most disadvantaged sections of the rural poor (mainly women, the landless and indigenous peoples). In order to overcome disadvantages arising from remoteness, lack of social services, insecure and unproductive jobs, and discrimination as women or ethnic minorities, the rural poor need legally secure access to productive assets (mainly land, forests and water); sustainable or regenerating agricultural technology; access to markets; opportunities to participate in decentralized resource management; and access to financial services

Relational approaches to poverty in rural India: social, ecological and technical dynamics

Poverty is now widely recognised as multidimensional, with indicators including healthcare, housing and sanitation. Yet, relational approaches that foreground political-cultural processes remain marginalised in policy discourses. Focusing on India, we review a wide range of relational approaches to rural poverty. Beginning with early approaches that focus on structural reproduction of class, caste and to a lesser extent gender inequality, we examine new relational approaches developed in the last two decades. The new approaches examine diverse ways in which poverty is experienced and shapes mobilisations against deprivation. They draw attention to poor people’s own articulations of deprivation and alternate conceptions of well-being. They also show how intersecting inequalities of class, caste and gender shape governance practices and political movements. Despite these important contributions, the new relational approaches pay limited attention to technologies and ecologies in shaping the experience of poverty. Reviewing studies on the Green Revolution and wider agrarian transformations in India, we then sketch the outlines of a hybrid relational approach to poverty that combines socio-technical and -ecological dynamics. We argue that such an approach is crucial to challenge narrow economising discourses on poverty and to bridge the policy silos of poverty alleviation and (environmentally) sustainable development

Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy

The epidermal growth factor receptor (EGFR) is a validated target in squamous cell carcinoma (SCC) of the head and neck. Most patients, however, do not respond or develop resistance to this agent. Mammalian target of rapamycin (mTOR) is involved in the pathogenesis of SCC of the head and neck (SCCHN). This study aimed to determine if targeting mTOR in combination with EGFR is effective in SCC, and to develop early pharmacodynamic markers of efficacy. Two SCC cell lines, one resistant (HEP2) and one of intermediate susceptibility (Detroit 562) to EGFR inhibitors, were xenografted in vivo and treated with an mTOR inhibitor (temsirolimus), an EGFR inhibitor (erlotinib) or a combination of both. Temsirolimus exerted superior growth arrest in both cell lines than erlotinib. The combined treatment resulted in synergistic antitumor effects in the Detroit 562 cell line. Immunohistochemical assessment of pharmacodynamic effects in fine-needle aspiration (FNA) biopsies early after treatment using phospho MAPK, Phospho-P70 and Ki67 as end points demonstrated pathway abrogation in the Detroit 562 tumours treated with the combination, the only group where regressions were seen. In conclusion, an mTOR inhibitor showed antitumor activity in EGFR-resistant SCC cell lines. Marked antitumor effects were associated with dual pathway inhibition, which were detected by early FNA biopsies

Recipes for Attention: Policy Reforms, Crises, Organizational Characteristics, and the Newspaper Coverage of the LGBT Movement, 1969–2009

Why do some organizations in a movement seeking social change gain extensive national newspaper coverage? To address the question, we innovate in theoretical and empirical ways. First, we elaborate a theoretical argument that builds from the political mediation theory of movement consequences and incorporates the social organization of newspaper practices. This media and political mediation model integrates political and media contexts and organizations' characteristics and actions. With this model, we hypothesize two main routes to coverage: one that includes changes in public policy and involves policy-engaged, well-resourced, and inclusive organizations and a second that combines social crises and protest organizations. Second, we appraise these arguments with the first analysis of the national coverage of all organizations in a social movement over its career: 84 lesbian, gay, bisexual, and transgender rights and AIDS-related organizations in the New York Times, Los Angeles Times, and Wall Street Journal from 1969 to 2010. These analyses go beyond previous research that provides either snapshots of many organizations at one point in time or overtime analyses of aggregated groups of organizations or individual organizations. The results of both historical and fuzzy set qualitative comparative analyses support our media and political mediation model.NSF [SES-0752571, SES-1023863]24 month embargo; First published: 26 July 2016This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]