21 research outputs found
Gastric cancer screening by combined assay for serum anti-Helicobacter pylori IgG antibody and serum pepsinogen levels â âABC methodâ
The current status of screening for gastric cancer-risk (gastritis A, B, C, D) method using combined assay for serum anti-Helicobacter pylori (Hp) IgG antibody and serum pepsinogen (PG) levels, âABC methodâ, was reviewed and the latest results of our ongoing trial are reported. It was performed using the following strategy: Subjects were classified into 1 of 4 risk groups based on the results of the two serologic tests, anti-Hp IgG antibody titers and the PG I and II levels: Group A [Hp(â)PG(â)], infection-free subjects; Group B [Hp(+)PG(â)], chronic atrophic gastritis (CAG) free or mild; Group C [Hp(+)PG(+)], CAG; Group D [Hp(â)PG(+)]), severe CAG with extensive intestinal metaplasia. Continuous endoscopic follow-up examinations are required to detect early stages of gastric cancer. Asymptomatic Group A, which accounts for 50â80% of all the subjects may be excluded from the secondary endoscopic examination, from the viewpoint of efficiency. Hp-infected subjects should be administered eradication treatment aimed at the prevention of gastric cancer
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A methodology for evaluating potential KBS (Knowledge-Based Systems) applications
It is often difficult to assess how well Knowledge-Based Systems (KBS) techniques and paradigms may be applied to automating various tasks. This report describes the approach and organization of an assessment procedure that involves two levels of analysis. Level One can be performed by individuals with little technical expertise relative to KBS development, while Level Two is intended to be used by experienced KBS developers. The two levels review four groups of issues: goals, appropriateness, resources, and non-technical considerations. Those criteria are identified which are important at each step in the assessment. A qualitative methodology for scoring the task relative to the assessment criteria is provided to alloy analysts to make better informed decisions with regard to the potential effectiveness of applying KBS technology. In addition to this documentation, the assessment methodology has been implemented for personal computers use using the HYPERCARD{trademark} software on a Macintosh{trademark} computer. This interactive mode facilities small group analysis of potential KBS applications and permits a non-sequential appraisal with provisions for automated note-keeping and question scoring. The results provide a useful tool for assessing the feasibility of using KBS techniques in performing tasks in support of treaty verification or IC functions. 13 refs., 3 figs